Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported […] Written by Admin January 13, 2025January 13, 2025 Saving Bookmark this article Bookmarked
2024 Confirmed As Hottest Year on Record, Part of Sustained Upward March – State of the Planet Earth’s average surface temperature in 2024 was the warmest since modern record keeping began in 1880, according to an analysis led by NASA scientists. Global temperatures in 2024 were 2.30 degrees Fahrenheit (1.28 degrees Celsius) above the agency’s 20th-century baseline (1951-1980), which tops the record set in 2023. The new record comes after 15 consecutive months (June […] Written by Columbia Climate School January 13, 2025January 13, 2025 Saving Bookmark this article Bookmarked
Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported […] Written by Admin January 13, 2025January 13, 2025 Saving Bookmark this article Bookmarked
2024 Confirmed As Hottest Year on Record, Part of Sustained Upward March – State of the Planet Earth’s average surface temperature in 2024 was the warmest since modern record keeping began in 1880, according to an analysis led by NASA scientists. Global temperatures in 2024 were 2.30 degrees Fahrenheit (1.28 degrees Celsius) above the agency’s 20th-century baseline (1951-1980), which tops the record set in 2023. The new record comes after 15 consecutive months (June […] Written by Columbia Climate School January 13, 2025January 13, 2025 Saving Bookmark this article Bookmarked
Study shows how plant roots access deeper soils in search of water Scientists have discovered how plants adapt their root systems in drought conditions to grow steeper into the soil to access deeper water reserves. Plant scientists from the University of Nottingham, in collaboration with Shanghai Jiao Tong University, have identified how abscisic acid (ABA), a plant hormone known for its role in drought response, influences root […] Written by Admin January 13, 2025January 13, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked
