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An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis

Precisely controlled remodeling of the basement membrane (BM) is crucial for morphogenesis, but its molecular and tissue-level dynamics, underlying mechanisms, and functional significance in mammals remain largely unknown due to limited visualization tools. We developed mouse lines in which the endogenous collagen IV gene (Col4a2) was fused with a fluorescent tag. Through live imaging of […]
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Improving U.S. Coastal Protection and Resilience – State of the Planet

Hurricanes Helene and Milton have left massive damage and loss in communities across the Southeast and Gulf of the U.S. Yet this may just be the beginning. With near record-warm ocean temperatures in the Atlantic, the National Oceanic and Atmospheric Administration (NOAA) has predicted a dangerous hurricane season with a record number of storms. Millions […]
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An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis

Precisely controlled remodeling of the basement membrane (BM) is crucial for morphogenesis, but its molecular and tissue-level dynamics, underlying mechanisms, and functional significance in mammals remain largely unknown due to limited visualization tools. We developed mouse lines in which the endogenous collagen IV gene (Col4a2) was fused with a fluorescent tag. Through live imaging of […]
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Improving U.S. Coastal Protection and Resilience – State of the Planet

Hurricanes Helene and Milton have left massive damage and loss in communities across the Southeast and Gulf of the U.S. Yet this may just be the beginning. With near record-warm ocean temperatures in the Atlantic, the National Oceanic and Atmospheric Administration (NOAA) has predicted a dangerous hurricane season with a record number of storms. Millions […]
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Scientists uncover new way viruses fight back against bacteria

Noninvasive imaging method can penetrate deeper into living tissue

Metabolic imaging is a noninvasive method that enables clinicians and scientists to study living cells using laser light, which can help them assess disease progression and treatment responses. But light scatters when it shines into biological tissue, limiting how deep it can penetrate and hampering the resolution of captured images. Now, MIT researchers have developed […]
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