Biology

  1. Biology
The malaria-causing parasite, P. falciparum, replicates through schizogony, a tightly orchestrated process where numerous daughter parasites are formed simultaneously. Proper division and segregation of one-per-cell organelles, like the mitochondrion and apicoplast, are essential, yet remain poorly understood. We developed a new reporter parasite line that allows visualization of the mitochondrion in blood and mosquito stages. […]
  1. Biology
For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […]
  1. Biology
The syncytial mammalian muscle fiber contains a heterogeneous population of (myo)nuclei. At the neuromuscular junction (NMJ), myonuclei have specialized positioning and gene expression. However, it remains unclear how myonuclei are recruited and what regulates myonuclear output at the NMJ. Here, we identify specific properties of myonuclei located near the Drosophila larval NMJ. These synaptic myonuclei […]
  1. Biology
Racecar drivers use left-foot braking, i.e., simultaneously engaging brake and throttle, to carefully balance acceleration and traction when navigating chicanes. In this issue, Lara-Gonzalez et al. (https://doi.org/10.1083/jcb.202308034) show that C. elegans embryos employ the molecular equivalent of left-foot braking to faithfully speed through mitosis.
  1. Biology
Cell motility is crucial for many biological processes including morphogenesis, wound healing, and cancer invasion. The WAVE regulatory complex (WRC) is a central Arp2/3 regulator driving cell motility downstream of activation by Rac GTPase. CYFIP-related Rac1 interactor (CYRI) proteins are thought to compete with WRC for interaction with Rac1 in a feedback loop regulating lamellipodia […]
  1. Biology
Because of their special properties – heat resistance, water and grease repellence, and high durability – PFAS are used in many everyday products (e.g. cosmetics, outdoor clothing, and coated cookware). But it is precisely these properties that make them so problematic. “Because some PFAS are chemically stable, they accumulate in the environment and enter our […]
  1. Biology
VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a […]
  1. Biology
LOS ANGELES — Oncology specialists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, can now provide leading-edge clinical guidance to patients living in Southeast Asia through a second opinion collaboration agreement with the Healthway Cancer Care Hospital, the first comprehensive cancer hospital in […]

Good Reads

Jonathan Dickinson brings extensive biotech and pharma experience to Marseille-based Innate Pharma. He comes from Incyte, where he served as Executive Vice President and General Manager Europe since 2016. Prior to that, he gained significant leadership experience through several senior positions at oncology focused ARIAD Pharmaceuticals and Bristol-Myers Squibb. This followed a distinguished 13-year tenure […]
For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […]

Worlwide

Jonathan Dickinson brings extensive biotech and pharma experience to Marseille-based Innate Pharma. He comes from Incyte, where he served as Executive Vice President and General Manager Europe since 2016. Prior to that, he gained significant leadership experience through several senior positions at oncology focused ARIAD Pharmaceuticals and Bristol-Myers Squibb. This followed a distinguished 13-year tenure […]
For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […]
Damaged solar panels in eastern Puerto Rico. Photo: Lorie Shaull “The world’s capacity to generate renewable electricity is expanding faster than at any time in the last three decades,” the International Energy Agency said in a report published earlier this year. This sign of growth offers “a real chance of achieving the goal of tripling global […]

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