Biology

  1. Biology
Vacuolar protein sorting 41 (VPS41), a component of the homotypic fusion and protein sorting (HOPS) complex for lysosomal fusion, is essential for the trafficking of lysosomal membrane proteins via lysosome-associated membrane protein (LAMP) carriers from the trans-Golgi network (TGN) to endo/lysosomes. However, the molecular mechanisms underlying this pathway and VPS41’s role herein remain poorly understood. […]
  1. Biology
Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […]
  1. Biology
NASA’s OSIRIS‑REx mission has ushered in a new era in our understanding of prebiotic chemistry and the dynamic nature of small Solar System bodies by returning pristine samples from the near‑Earth asteroid Bennu. In a groundbreaking development that challenges long‑standing assumptions regarding the origins of life on our planet, researchers have discovered that Bennu’s fragments […]
  1. Biology
Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved and what is their functional significance in tissue morphogenesis and maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. […]
  1. Biology
Researchers at Durham University have made significant strides in understanding the intricate relationship between proteins and metal binding in cellular environments, a vital process that underpins many biological functions essential for life. This groundbreaking research, recently published in Nature Communications, unveils an innovative methodology allowing scientists to accurately forecast and engineer the binding of metals […]
  1. Biology
Mitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have “intergenomic signaling” pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes encoded by mtDNA. However, MRS pathways that sense the amount […]
  1. Biology
New research unveiled at the 2025 Society of Thoracic Surgeons (STS) Annual Meeting has significant implications for the surgical treatment outcomes in patients diagnosed with early-stage non-small cell lung cancer (NSCLC). This study examines the long-term survival rates associated with different surgical approaches, particularly anatomic lung resections like lobectomy and segmentectomy, in contrast to wedge […]
  1. Biology
Centrioles are microtubule-based organelles required for the formation of centrosomes and cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very slowly, but the underlying mechanisms are poorly understood. Here, we reconstituted in vitro the interplay between the proteins that cap distal centriole ends and control their elongation: CP110, CEP97, and CPAP/SAS-4. We […]
  1. Biology
Pregnant People with Multiple Sclerosis Are at Increased Risk for Mental Illness Recent studies have raised alarm bells about the mental health implications faced by pregnant individuals diagnosed with multiple sclerosis (MS). A comprehensive study, published in the esteemed journal Neurology, emphasizes the fact that expectant parents with MS are significantly more susceptible to mental […]

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Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […]

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Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […]

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