Biology Detailing organelle division and segregation in Plasmodium falciparum The malaria-causing parasite, P. falciparum, replicates through schizogony, a tightly orchestrated process where numerous daughter parasites are formed simultaneously. Proper division and segregation of one-per-cell organelles, like the mitochondrion and apicoplast, are essential, yet remain poorly understood. We developed a new reporter parasite line that allows visualization of the mitochondrion in blood and mosquito stages. […] Written by Admin November 4, 2024November 4, 2024 Saving Bookmark this article Bookmarked
Biology Kinetochores grip microtubules with directionally asymmetric strength For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […] Written by Admin November 3, 2024November 3, 2024 Saving Bookmark this article Bookmarked
Biology Postsynaptic BMP signaling regulates myonuclear properties in Drosophila larval muscles The syncytial mammalian muscle fiber contains a heterogeneous population of (myo)nuclei. At the neuromuscular junction (NMJ), myonuclei have specialized positioning and gene expression. However, it remains unclear how myonuclei are recruited and what regulates myonuclear output at the NMJ. Here, we identify specific properties of myonuclei located near the Drosophila larval NMJ. These synaptic myonuclei […] Written by Admin November 1, 2024November 1, 2024 Saving Bookmark this article Bookmarked
Biology Racing through C. elegans mitosis using cyclin B3 Racecar drivers use left-foot braking, i.e., simultaneously engaging brake and throttle, to carefully balance acceleration and traction when navigating chicanes. In this issue, Lara-Gonzalez et al. (https://doi.org/10.1083/jcb.202308034) show that C. elegans embryos employ the molecular equivalent of left-foot braking to faithfully speed through mitosis. Written by Admin October 30, 2024October 30, 2024 Saving Bookmark this article Bookmarked
Biology CYRI controls epidermal wound closure and cohesion of invasive border cell cluster in Drosophila Cell motility is crucial for many biological processes including morphogenesis, wound healing, and cancer invasion. The WAVE regulatory complex (WRC) is a central Arp2/3 regulator driving cell motility downstream of activation by Rac GTPase. CYFIP-related Rac1 interactor (CYRI) proteins are thought to compete with WRC for interaction with Rac1 in a feedback loop regulating lamellipodia […] Written by Admin October 26, 2024October 26, 2024 Saving Bookmark this article Bookmarked
Biology Distinct roles of two homologous kinesins in mammalian motile cilia How do the two kinesin-9 members Kif6 and Kif9 function in mammalian cilia? Ou and colleagues discuss new work from Fang et al. (https://doi.org/10.1083/jcb.202312060) showing that Kif6 is an active motor while Kif9 serves as a stationary regulator, both of which are essential for cilia motility. Written by Admin October 25, 2024October 25, 2024 Saving Bookmark this article Bookmarked
Biology PFAS influence the development and function of the brain Because of their special properties – heat resistance, water and grease repellence, and high durability – PFAS are used in many everyday products (e.g. cosmetics, outdoor clothing, and coated cookware). But it is precisely these properties that make them so problematic. “Because some PFAS are chemically stable, they accumulate in the environment and enter our […] Written by Admin September 25, 2024September 25, 2024 Saving Bookmark this article Bookmarked
Biology At-risk butterflies more likely to survive with human help VANCOUVER, Wash. – Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. VANCOUVER, Wash. – Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a […] Written by Admin September 24, 2024September 24, 2024 Saving Bookmark this article Bookmarked
Biology City of Hope to offer second opinions for cancer patients in Southeast Asia LOS ANGELES — Oncology specialists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, can now provide leading-edge clinical guidance to patients living in Southeast Asia through a second opinion collaboration agreement with the Healthway Cancer Care Hospital, the first comprehensive cancer hospital in […] Written by Admin September 22, 2024September 22, 2024 Saving Bookmark this article Bookmarked
Biology ‘EPR on a chip’ ensures quality of olive oil and beer The first sign of spoilage in many food products is the formation of free radicals, which reduces the shelf-life and the overall quality of the food. Until now, the detection of these molecules has been very costly for the food companies. Researchers at HZB and the University of Stuttgart have developed a portable, small and […] Written by Admin September 20, 2024September 20, 2024 Saving Bookmark this article Bookmarked
CEO and Chairman of the Executive Board Jonathan Dickinson brings extensive biotech and pharma experience to Marseille-based Innate Pharma. He comes from Incyte, where he served as Executive Vice President and General Manager Europe since 2016. Prior to that, he gained significant leadership experience through several senior positions at oncology focused ARIAD Pharmaceuticals and Bristol-Myers Squibb. This followed a distinguished 13-year tenure […] Written by Maren Kühr November 3, 2024November 3, 2024 Saving Bookmark this article Bookmarked
Kinetochores grip microtubules with directionally asymmetric strength For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […] Written by Admin November 3, 2024November 3, 2024 Saving Bookmark this article Bookmarked
CEO and Chairman of the Executive Board Jonathan Dickinson brings extensive biotech and pharma experience to Marseille-based Innate Pharma. He comes from Incyte, where he served as Executive Vice President and General Manager Europe since 2016. Prior to that, he gained significant leadership experience through several senior positions at oncology focused ARIAD Pharmaceuticals and Bristol-Myers Squibb. This followed a distinguished 13-year tenure […] Written by Maren Kühr November 3, 2024November 3, 2024 Saving Bookmark this article Bookmarked
Kinetochores grip microtubules with directionally asymmetric strength For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […] Written by Admin November 3, 2024November 3, 2024 Saving Bookmark this article Bookmarked
How Climate Change Impacts Affect Renewable Energy – State of the Planet Damaged solar panels in eastern Puerto Rico. Photo: Lorie Shaull “The world’s capacity to generate renewable electricity is expanding faster than at any time in the last three decades,” the International Energy Agency said in a report published earlier this year. This sign of growth offers “a real chance of achieving the goal of tripling global […] Written by Renée Cho November 3, 2024November 3, 2024 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked