Biology

  1. Biology

Targeting Aerobic Glycolysis to Combat Bladder Cancer Resistance

Research in the field of cancer biology has consistently revealed critical insights into the mechanisms underpinning tumor progression and drug resistance. Recent studies have illuminated the role of aerobic glycolysis, a process where cancer cells preferentially convert glucose to lactate, in the development of drug resistance in various malignancies. A groundbreaking investigation conducted by Weng, […]
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  1. Biology

Independent nuclear and organellar mechanisms determine apicoplast fate in malaria parasites

The apicoplast organelle of the malaria parasite, Plasmodium falciparum, is essential for parasite replication, though its cell cycle regulation remains poorly understood. We developed a dynamic live-imaging platform with analytical capabilities to track subcellular structures throughout the parasite’s 48-h intraerythrocytic life cycle. Our analysis revealed four distinct morphological stages in apicoplast development that correlate with […]
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  1. Biology

Transparent Solar Cells with UV-Blocking Fluorene Dyes

Recent advancements in solar cell technology have opened up new frontiers in the pursuit of sustainable and efficient energy solutions. One of the most compelling developments in this realm is the emergence of highly transparent dye-sensitized solar cells (DSSCs). Researchers have been delving into the intricacies of these solar cells that not only promise greater […]
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  1. Biology

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

Receptor tyrosine kinases (RTKs) are important cargo in endocytic trafficking, yet their role in endosomal sorting and maturation of multivesicular bodies remains unclear. Here, we show that the ErbB3 (HER3) receptor sorts internalized Integrin β1 and the transferrin receptor, for endocytic recycling, in a manner that does not require ligand-induced ErbB3 signaling in breast epithelial […]
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  1. Biology

Boosting Cancer Immunotherapy by Targeting DNA Repair

In the relentless pursuit of more effective cancer treatments, a burgeoning field of research has been focusing on an intricate cellular process known as the DNA damage response (DDR). Recent advances have illuminated how manipulating DDR pathways can substantially enhance the effectiveness of cancer immunotherapy, a revolutionary treatment modality that harnesses the body’s immune system […]
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  1. Biology

High-resolution mapping of the actin fusion focus reveals myosin V–dependent formin transport for aster formation

Many processes such as polarized growth and secretion require specific actin networks. In fungi, cell–cell fusion requires cell wall digestion mediated by local secretion of lytic enzymes. In Schizosaccharomyces pombe, the myosin V Myo52 transports enzyme-containing secretory vesicles on the actin fusion focus, an aster-like actin network assembled by the condensate-forming formin Fus1. The fusion […]
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  1. Biology

Dexmedetomidine Enhances Neurocognitive Recovery in Aged Mice

In a groundbreaking study published in BMC Neuroscience, researchers have unveiled the remarkable effects of dexmedetomidine pretreatment on neurocognitive recovery in aged mice following surgical procedures. This research, led by scientists Q. Zhang, S. Hao, and G. Wang, sheds light on the intricate mechanisms at play in the aging brain and their implications for enhancing […]
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  1. Biology

Is the Parkinson’s-associated protein TMEM175 a proton channel: Yay or nay?

The abnormal protein degradation implicated in the pathogenesis of Parkinson’s disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K+ channel, minimally permeable to H+.
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  1. Biology

Luedeking-Piret Model Advances Multi-Step mAb Forecasting

In the rapidly evolving landscape of biopharmaceutical manufacturing, monoclonal antibodies (mAbs) have surged to the forefront as indispensable therapeutic agents. Their complex production processes, however, pose significant engineering challenges, particularly in predicting yield and quality over multi-step production sequences. A recent groundbreaking study by Wang, Verma, Chiu, and colleagues, published in Communications Engineering in 2025, […]
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  1. Biology

Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis

Mitophagy transports mitochondria to lysosomes for degradation to maintain energy homeostasis, inflammation, and immunity. Here, we identify CipB, a type III secretion system (T3SS) effector from Chromobacterium violaceum, as a novel exogenous mitophagy receptor. CipB targets mitochondria by the mitochondrial protein TUFM and recruits autophagosomes via its LC3-interacting region (LIR) motifs. This process initiates the […]
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Good Reads

Demand for Precise, Practical Neonatal Bilirubin Testing

Accurate and Actionable Neonatal Bilirubin Testing: A Critical Frontier in Newborn Care In the intricate landscape of neonatal medicine, the precision of bilirubin assays has emerged as a paramount concern that commands both clinical vigilance and laboratory excellence. Neonatal hyperbilirubinemia remains a widespread condition globally, implicating significant morbidity risks if not identified and managed with […]
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Demand for Precise, Practical Neonatal Bilirubin Testing

Accurate and Actionable Neonatal Bilirubin Testing: A Critical Frontier in Newborn Care In the intricate landscape of neonatal medicine, the precision of bilirubin assays has emerged as a paramount concern that commands both clinical vigilance and laboratory excellence. Neonatal hyperbilirubinemia remains a widespread condition globally, implicating significant morbidity risks if not identified and managed with […]
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Independent nuclear and organellar mechanisms determine apicoplast fate in malaria parasites

The apicoplast organelle of the malaria parasite, Plasmodium falciparum, is essential for parasite replication, though its cell cycle regulation remains poorly understood. We developed a dynamic live-imaging platform with analytical capabilities to track subcellular structures throughout the parasite’s 48-h intraerythrocytic life cycle. Our analysis revealed four distinct morphological stages in apicoplast development that correlate with […]
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