Biology

  1. Biology

Pancreatic Cancer Deaths in China: Trends Revealed

Over the past two decades, pancreatic cancer has emerged as a formidable public health challenge worldwide, with mortality rates climbing inexorably. A recent comprehensive study published in BMC Cancer presents a meticulous analysis of pancreatic cancer mortality trends in China from 2004 to 2021. Utilizing robust epidemiological data, this research offers unprecedented insights into how […]
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  1. Biology

Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport

Myo2, a class V myosin motor, is essential for organelle transport in budding yeast. Its association with cargo is regulated by adaptor proteins that mediate both attachment and release. Vac17, a vacuole-specific adaptor, links Myo2 to the vacuole membrane protein Vac8 and plays a key role in assembling and disassembling the Myo2–Vac17–Vac8 complex during vacuole […]
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  1. Biology

Broad-Spectrum Covalent Inhibitor Targets Coronavirus Mpro

In a groundbreaking leap forward for antiviral drug development, researchers have unveiled a novel covalent inhibitor that shows broad-spectrum efficacy against the main protease (M^pro) of human coronaviruses. This breakthrough illuminates a promising pathway toward universal antiviral therapies that could decisively curtail the threat posed by not only the current SARS-CoV-2 virus but also future […]
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  1. Biology

Anillin links up with RhoA to break the symmetry of cytokinetic ring closure

During animal cell cytokinesis, active RhoA assembles actomyosin-based contractile rings that tend to close asymmetrically. Through imaging C. elegans zygotes, Lebedev et al. (https://doi.org/10.1083/jcb.202405182) reveal that the scaffold protein, anillin, promotes asymmetric ring closure by locally sequestering RhoA from its canonical effectors and thereby limiting actomyosin contractility.
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  1. Biology

Extended Reality Boccia Demonstrates Promising Rehabilitation Benefits

In recent years, the integration of extended reality (XR) technologies into therapeutic and rehabilitation contexts has opened new horizons for enhancing physical and cognitive health, particularly in older adults. A pioneering research group from Osaka Metropolitan University has taken a bold step forward by developing an XR version of boccia, a precision ball sport traditionally […]
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  1. Biology

CDK4/6 Inhibitors Boost First-Line Breast Cancer Therapy

In an ambitious stride toward optimizing treatment for hormone receptor-positive (HR+)/HER2-negative advanced breast cancer, a recent comprehensive network meta-analysis has brought fresh insights into the comparative efficacy and safety of the four widely used CDK4/6 inhibitors combined with aromatase inhibitors (AI). Published in the upcoming 2025 volume of BMC Cancer, this pioneering study meticulously synthesizes […]
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  1. Biology

Rewrite Longitudinal profiling of low-abundance strains in microbiomes with

The ability to detect and quantify microbiota over time from shotgun metagenomic data has a plethora of clinical, basic science and public health applications. Given these applications, and the observation that pathogens and other taxa of interest can reside at low relative abundance, there is a critical need for algorithms that accurately profile low-abundance microbial […]
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  1. Biology

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

KRAS, a small GTPase involved in cell proliferation and differentiation, frequently gains activating mutations in human cancers. For KRAS to function, it must bind the plasma membrane (PM) via interactions between its membrane anchor and phosphatidylserine (PtdSer). Therefore, depleting PM PtdSer abrogates KRAS PM binding and activity. From a genome-wide siRNA screen to identify genes […]
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Good Reads

Pancreatic Cancer Deaths in China: Trends Revealed

Over the past two decades, pancreatic cancer has emerged as a formidable public health challenge worldwide, with mortality rates climbing inexorably. A recent comprehensive study published in BMC Cancer presents a meticulous analysis of pancreatic cancer mortality trends in China from 2004 to 2021. Utilizing robust epidemiological data, this research offers unprecedented insights into how […]
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A Small Island Offers Big Lessons in Sustainability – State of the Planet

Far from the bustle of Columbia’s campus, a group of undergraduate students in degree programs managed by the Climate School Office of Undergraduate Programs recently journeyed to Cuttyhunk Island, Massachusetts, to explore sustainability through lived experience. The Cuttyhunk Practicum, which began in 2024 as a partnership between Columbia and Barnard professors Jason Smerdon and Sandra […]
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Worlwide

Pancreatic Cancer Deaths in China: Trends Revealed

Over the past two decades, pancreatic cancer has emerged as a formidable public health challenge worldwide, with mortality rates climbing inexorably. A recent comprehensive study published in BMC Cancer presents a meticulous analysis of pancreatic cancer mortality trends in China from 2004 to 2021. Utilizing robust epidemiological data, this research offers unprecedented insights into how […]
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A Small Island Offers Big Lessons in Sustainability – State of the Planet

Far from the bustle of Columbia’s campus, a group of undergraduate students in degree programs managed by the Climate School Office of Undergraduate Programs recently journeyed to Cuttyhunk Island, Massachusetts, to explore sustainability through lived experience. The Cuttyhunk Practicum, which began in 2024 as a partnership between Columbia and Barnard professors Jason Smerdon and Sandra […]
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Countdown to SLAS Europe: NestEgg Labs BV

Countdown to SLAS Europe: NestEgg Labs BV

Founded in 2022 by Tanner Carden (CEO) and Hans Keijdener, Maastricht-based start-up NestEgg Labs BV focuses on developing interoperable automation systems for cell culture that reduce manual intervention, improve workflow reproducibility, and limit plastics waste. At the core of NestEgg’s offering is Ovation, a smart incubator platform designed to automate key stages of the cell […]
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