Biology VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b Vacuolar protein sorting 41 (VPS41), a component of the homotypic fusion and protein sorting (HOPS) complex for lysosomal fusion, is essential for the trafficking of lysosomal membrane proteins via lysosome-associated membrane protein (LAMP) carriers from the trans-Golgi network (TGN) to endo/lysosomes. However, the molecular mechanisms underlying this pathway and VPS41’s role herein remain poorly understood. […] Written by Admin February 8, 2025February 8, 2025 Saving Bookmark this article Bookmarked
Biology Optimizing Effective Integration of Artificial Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […] Written by Bioengineer February 6, 2025February 6, 2025 Saving Bookmark this article Bookmarked
Biology New editorial board members Written by Admin February 4, 2025February 4, 2025 Saving Bookmark this article Bookmarked
Biology Bennu’s Dual-Chirality Amino Acids Spark NASA’s OSIRIS‑REx mission has ushered in a new era in our understanding of prebiotic chemistry and the dynamic nature of small Solar System bodies by returning pristine samples from the near‑Earth asteroid Bennu. In a groundbreaking development that challenges long‑standing assumptions regarding the origins of life on our planet, researchers have discovered that Bennu’s fragments […] Written by Bioengineer February 2, 2025February 2, 2025 Saving Bookmark this article Bookmarked
Biology Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved and what is their functional significance in tissue morphogenesis and maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. […] Written by Admin January 31, 2025January 31, 2025 Saving Bookmark this article Bookmarked
Biology Groundbreaking Discovery by Durham University Scientists in Predicting and Researchers at Durham University have made significant strides in understanding the intricate relationship between proteins and metal binding in cellular environments, a vital process that underpins many biological functions essential for life. This groundbreaking research, recently published in Nature Communications, unveils an innovative methodology allowing scientists to accurately forecast and engineer the binding of metals […] Written by Bioengineer January 30, 2025January 30, 2025 Saving Bookmark this article Bookmarked
Biology FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion Mitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have “intergenomic signaling” pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes encoded by mtDNA. However, MRS pathways that sense the amount […] Written by Admin January 28, 2025January 28, 2025 Saving Bookmark this article Bookmarked
Biology Enhanced Survival Rates Observed with Anatomic Lung Resection in New research unveiled at the 2025 Society of Thoracic Surgeons (STS) Annual Meeting has significant implications for the surgical treatment outcomes in patients diagnosed with early-stage non-small cell lung cancer (NSCLC). This study examines the long-term survival rates associated with different surgical approaches, particularly anatomic lung resections like lobectomy and segmentectomy, in contrast to wedge […] Written by Bioengineer January 26, 2025January 26, 2025 Saving Bookmark this article Bookmarked
Biology Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends Centrioles are microtubule-based organelles required for the formation of centrosomes and cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very slowly, but the underlying mechanisms are poorly understood. Here, we reconstituted in vitro the interplay between the proteins that cap distal centriole ends and control their elongation: CP110, CEP97, and CPAP/SAS-4. We […] Written by Admin January 24, 2025January 24, 2025 Saving Bookmark this article Bookmarked
Biology Pregnancy May Heighten Mental Health Risks for Individuals with MS Pregnant People with Multiple Sclerosis Are at Increased Risk for Mental Illness Recent studies have raised alarm bells about the mental health implications faced by pregnant individuals diagnosed with multiple sclerosis (MS). A comprehensive study, published in the esteemed journal Neurology, emphasizes the fact that expectant parents with MS are significantly more susceptible to mental […] Written by Bioengineer January 22, 2025January 22, 2025 Saving Bookmark this article Bookmarked
Fishing and conserving in Great Barrier Reef’s marine reserves A new study of the Great Barrier Reef has revealed that the network of no-take marine reserves supplies nearly half of the region’s coral trout fishery catch. The research, led by Professor Michael Bode from the QUT School of Mathematical Sciences and published in Science Advances, revealed that despite covering only 30 per cent of […] Written by Admin February 6, 2025February 6, 2025 Saving Bookmark this article Bookmarked
Optimizing Effective Integration of Artificial Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […] Written by Bioengineer February 6, 2025February 6, 2025 Saving Bookmark this article Bookmarked
Fishing and conserving in Great Barrier Reef’s marine reserves A new study of the Great Barrier Reef has revealed that the network of no-take marine reserves supplies nearly half of the region’s coral trout fishery catch. The research, led by Professor Michael Bode from the QUT School of Mathematical Sciences and published in Science Advances, revealed that despite covering only 30 per cent of […] Written by Admin February 6, 2025February 6, 2025 Saving Bookmark this article Bookmarked
Optimizing Effective Integration of Artificial Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […] Written by Bioengineer February 6, 2025February 6, 2025 Saving Bookmark this article Bookmarked
‘Ban bottom trawling now’ A Labour MP has called for a blanket ban on “bottom trawling” of seabeds in marine protected areas (MPAs), which she said destroys fragile ecosystems and habitats. Katie White compared bottom trawling, which is the act of dragging heavy nets across the seabed, with “ripping up an orchard to pick an apple”. One or two […] Written by brendan February 6, 2025February 6, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked