Clinical

  1. Clinical

EILEAN THERAPEUTICS RECEIVES CLEARANCE TO INITIATE R/R AML TRIAL WITH LOMONITINIB, A SELECTIVE PAN-FLT3/IRAK4 INHIBITOR

DOVER, Del., April 4, 2024. Eilean Therapeutics LLC, a biopharmaceutical firm devoted to discovering and growing best-in-class and first-in-class small molecule inhibitors to focus on escape mutations in hematologic and stable malignancies, is happy to announce the clearance from the Human Analysis Ethics Committee in Australia for lomonitinib (ZE46-0134) permitting the corporate to proceed with […]
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  1. Clinical

First Affected person Dosed in Section 2a Medical Trial of a First-in-Class Regenerative Cell Remedy for Sufferers with Finish-Stage Liver Illness

PITTSBURGH, April 2, 2024. LyGenesis, a clinical-stage biotechnology firm growing cell therapies for big unmet medical wants, introduced right this moment that the primary affected person has been dosed of their Section 2a scientific trial evaluating their first-in-class allogenic regenerative cell remedy transplanted into sufferers’ lymph nodes as a possible remedy for […]
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  1. Clinical

Tonix Prescription drugs Receives Uncommon Pediatric Illness Designation from the FDA for TNX-2900 for the Therapy of Prader-Willi Syndrome

CHATHAM, N.J., March 25, 2024 (GLOBE NEWSWIRE) — Tonix Prescription drugs Holding Corp. (Nasdaq: TNXP) (Tonix or the Firm), a biopharmaceutical firm with marketed merchandise and a pipeline of growth candidates, as we speak introduced the U.S. Meals and Drug Administration (FDA) has granted Uncommon Pediatric Illness Designation to TNX-2900* (intranasal potentiated oxytocin), a proprietary […]
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  1. Clinical

Constructive Interim Part I Outcomes of Zolmitriptan Transdermal Microporation System for the Therapy of Acute Migraine

SAN DIEGO, March 29, 2024. PassPort Applied sciences, Inc. (PPTI), based mostly in San Diego, a clinical-stage drug and medical machine growth firm, in the present day introduced optimistic interim outcomes from the Part 1 (Half A) scientific trial of Zolmitriptan PassPort using its proprietary transdermal microporation system for the remedy of acute migraine. Zolmitriptan […]
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  1. Clinical

Johnson & Johnson’s Nipocalimab Granted U.S. FDA Quick Observe Designation to Cut back the Threat of Fetal Neonatal Alloimmune Thrombocytopenia (FNAIT) in Alloimmunized Pregnant Adults

SPRING HOUSE, Pa. March 26, 2024 – Johnson & Johnson introduced right now that the U.S. Meals and Drug Administration (FDA) has granted Quick Observe designation (FTD) for nipocalimab to cut back the chance of FNAIT in alloimmunizeda pregnant adults throughout their present being pregnant. FNAIT is a uncommon and extreme situation that happens when […]
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  1. Clinical

Invivyd Publicizes FDA Authorization for Emergency Use of Pemgarda (Previously VYD222) for Pre-Publicity Prophylaxis (PrEP) of COVID-19

WALTHAM, Mass., March 22, 2024 (GLOBE NEWSWIRE) — Invivyd, Inc. (Nasdaq: IVVD), a biopharmaceutical firm on a mission to guard the weak from severe viral infectious ailments, as we speak introduced that Pemgarda™ (pemivibart), previously VYD222, a half-life prolonged monoclonal antibody (mAb), has acquired emergency use authorization (EUA) from the U.S. Meals and Drug Administration […]
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  1. Clinical

Lisata Therapeutics Pronounces U.S. FDA Uncommon Pediatric Illness Designation Granted to LSTA1 for the Therapy of Osteosarcoma

BASKING RIDGE, N.J., March 21, 2024. Lisata Therapeutics, Inc. (“Lisata” or the “Firm”), a clinical-stage pharmaceutical firm growing progressive therapies for the remedy of superior strong tumors and different severe illnesses, at present introduced that the U.S. Meals and Drug Administration (the “FDA”) has granted Uncommon Pediatric Illness Designation (“RPDD”) to LSTA1, the Firm’s lead […]
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  1. Clinical

Invoice & Melinda Gates Medical Analysis Institute Initiates Part 3 Scientific Trial of Tuberculosis Vaccine Candidate

CAMBRIDGE, Mass., March 19, 2024. The Invoice & Melinda Gates Medical Analysis Institute (Gates MRI) right now introduced {that a} Part 3 scientific trial to evaluate the efficacy of the M72/AS01E tuberculosis (TB) vaccine candidate is now underway, with first doses given in South Africa, the place TB takes a heavy toll. If proven to […]
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  1. Clinical

Repurposed Drug Fenoprofen Exhibits Promise Towards Endometriosis-Associated Ache in Animal Mannequin

March 18, 2024 — Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), efficiently alleviated ache and irritation in a rodent mannequin of endometriosis, in response to researchers funded by the Nationwide Institutes of Well being (NIH). They selected the drug after utilizing a pc algorithm to guage practically 1,300 current compounds for his or her skill to […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

Constructive Outcomes from Part 3 BouNDless Trial of Investigational ND0612 in Folks with Parkinson’s Illness Experiencing Motor Fluctuation

JERSEY CITY, N.J., March 18, 2024. Mitsubishi Tanabe Pharma America, Inc. (MTPA) in the present day introduced the publication of leads to The Lancet Neurology from the pivotal, Part 3 BouNDless trial (NCT04006210) evaluating the efficacy, security and tolerability of investigational ND0612 – a steady, 24 hours/day subcutaneous (SC) infusion of liquid levodopa/carbidopa (LD/CD) – […]
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Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of […]
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Labour’s ‘deeply alarming’ attack on protest rights

British authorities have severely restricted the right to protest in contravention of their international human rights obligations, creating an environment in which peaceful dissent is increasingly treated as a criminal act, Human Rights Watch said in its latest report. ‘Silencing the Streets’: The Right to Protest Under Attack in the UK documents that the UK’s […]
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Worlwide

Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of […]
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Labour’s ‘deeply alarming’ attack on protest rights

British authorities have severely restricted the right to protest in contravention of their international human rights obligations, creating an environment in which peaceful dissent is increasingly treated as a criminal act, Human Rights Watch said in its latest report. ‘Silencing the Streets’: The Right to Protest Under Attack in the UK documents that the UK’s […]
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