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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

One gene defines the many patterns of snake skin

In many animals, skin colouration and its patterns play a crucial role in camouflage, communication, or thermoregulation. In the corn snake, some morphs display red, yellow, or pink blotches, and their dorsal spots can merge or turn into stripes. But which genetic and cellular mechanisms determine these colourful patterns? A team from the University of […]
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  1. Pharmaceuticals and Drug Development

Aldeyra Therapeutics Receives Complete Response Letter from the U.S. Food and Drug Administration for the Reproxalap New Drug Application for the Treatment of Signs and Symptoms of Dry Eye Disease

LEXINGTON, Mass.–(BUSINESS WIRE)–Apr. 3, 2025– Aldeyra Therapeutics, Inc. (Nasdaq: ALDX) (Aldeyra), a biotechnology company devoted to discovering and developing innovative therapies designed to treat immune-mediated and metabolic diseases, today…
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  1. Biology

TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling

Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging.
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

The eukaryotic cell emerged as an evolutionary algorithmic phase transition

An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant increase in complexity in the history of life’s evolution on Earth: the origin of the eukaryotic cell. While the endosymbiotic theory is widely accepted, the billions of years […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Disrupting ‘communication’ with plants could limit soybean cyst nematode infections

Targeting a newly discovered vulnerability in the signals that cyst nematodes use to infect plant roots could be a powerful method for reducing the damage the parasitic worms cause in crops such as soybeans, according to a study co-authored by an Iowa State University professor. Researchers identified a single protein in cyst nematodes that triggers […]
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  1. Biology

ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13

Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational levels. In this study, we employed the CRISPR/Cas9-based screening of a ubiquitin ligase library to identify regulators of human peroxisomes. We discovered that ZBTB17 (MIZ1) […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

European potato genome decoded: Small gene pool with large differences

A research team has decoded the genome of historic potato cultivars and used this resource to develop an efficient method for analysis of hundreds of additional potato genomes. Potatoes are a staple food for over 1.3 billion people. But despite their importance for global food security, breeding successes have been modest. Some of the most […]
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  1. Biology

PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways

Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Secret to crocodylian longevity | ScienceDaily

Researchers examined teeth and skulls of 99 extinct crocodylomorph species and 20 living crocodylian species to reconstruct their dietary ecology and identify characteristics that helped some groups persist through two mass extinctions. They discovered that one secret tocrocodylian longevity is their remarkably flexible lifestyles, both in what they eat and the habitat in which they […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Unlocking the genetic basis of animal behavior using fruit flies

Understanding how genes influence complex behaviors remains one of biology’s most fascinating challenges. Now, however, in a recent study, researchers from Japan compiled a comprehensive dataset documenting the behaviors of over 30,000 fruit flies across 105 genetically distinct strains. This valuable resource captures individual and group behaviors under various conditions, providing unparalleled insights into the […]
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  1. Biology

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

Intracellular transport among organellar compartments occurs in two general ways: by membrane-bound carriers and membrane contacts. Specific circumstances that involve the coordination of these two modes of transport remain to be defined. By studying coat protein I (COPI) transport, we find that phosphatidylcholine with short acyl chains (sPC) is delivered through membrane contact from the […]
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