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  1. Biology

Submembrane liprin-α1 clusters spatially localize insulin granule fusion

Insulin granule fusion in pancreatic β cells localizes to where they contact the ECM of the islet capillaries. The mechanism(s) underpinning localization are unclear. Using glucose or high K+ stimulation or the global uncaging of Ca2+, we show granule fusion consistently focused to the β cell–ECM interface, suggesting a specific localization mechanism. We tested for […]
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Scientists recreate life’s first step: Linking amino acids to RNA
  1. Life Sciences

Scientists recreate life’s first step: Linking amino acids to RNA

Chemists at UCL have shown how two of biology’s most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of life four billion years ago. Amino acids are the building blocks of proteins, the “workhorses” of life essential to nearly every living process. But proteins cannot replicate or […]
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Bumble bees balance their diets with surprising precision
  1. Life Sciences

Bumble bees balance their diets with surprising precision

Move over gym rats. Bumble bees are now the true masters of macros. In the first long-term, community-level field study of wild bumble bee nutrition, a team of ecologists led by Northwestern University and the Chicago Botanic Garden discovered that wild bees aren’t just flitting from flower to flower, collecting pollen at random. Instead, they […]
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Scientists unlock nature’s secret to superfast mini robots
  1. Life Sciences

Scientists unlock nature’s secret to superfast mini robots

A collaborative team of researchers from the University of California, Berkeley, the Georgia Institute of Technology, and Ajou University in South Koreahas revealed that the unique fan-like propellers of Rhagovelia water striders — which allow them to glide across fast-moving streams — open and close passively, like a paintbrush, ten times faster than the blink […]
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500-million-year-old “squid” were actually ferocious worms
  1. Life Sciences

500-million-year-old “squid” were actually ferocious worms

Remarkable fossils found in North Greenland have helped researchers solve a 500-million-year-old puzzle surrounding squid-like ancestors. It was previously thought ancient organisms called nectocaridids, which bear a resemblance to squid, were a type of cephalopod – marine molluscs with tentacles and a prominent head. But scientists, co-led by the University of Bristol, have now shown […]
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Extinct human relatives left a genetic gift that helped people thrive in the Americas
  1. Life Sciences

Extinct human relatives left a genetic gift that helped people thrive in the Americas

A new study provides fresh evidence that ancient interbreeding with archaic human species may have provided modern humans with genetic variation that helped them adapt to new environments as they dispersed across the globe. The study, published in Science, focused on a gene known as MUC19, which is involved in the production of proteins that […]
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Most of Earth’s species came from explosive bursts of evolution
  1. Life Sciences

Most of Earth’s species came from explosive bursts of evolution

The British evolutionary biologist JBS Haldane is said to have quipped that any divine being evidently had ‘an ordinate fondness for beetles’. This bon mot conveyed an important truth: the ‘tree of life’ – the family tree of all species, living or extinct – is very uneven. In places, it resembles a dense thicket of […]
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Ancient predators and giant amphibians found in African fossil treasure trove
  1. Life Sciences

Ancient predators and giant amphibians found in African fossil treasure trove

An international team of paleontologists has spent more than 15 years excavating and studying fossils from Africa to expand our understanding of the Permian, a period of Earth’s history that began 299 million years ago and ended 252 million years ago with our planet’s largest and most devastating mass extinction. Led by researchers at the […]
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  1. Biology

Identification of organelle-specific autophagy regulators from tandem CRISPR screens

Autophagy is a conserved degradative process that promotes cellular homeostasis under stress conditions. Under nutrient starvation, autophagy is nonselective, promoting indiscriminate breakdown of cytosolic components. Conversely, selective autophagy is responsible for the specific turnover of damaged organelles. We hypothesized that selective autophagy may be regulated by signaling pathways distinct from those controlling starvation-induced autophagy, thereby […]
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Scientists uncover the lost shelduck that chose walking over flight
  1. Life Sciences

Scientists uncover the lost shelduck that chose walking over flight

The discovery of yet another unique animal species from Rēkohu Chatham Islands illustrates how the physical qualities of an animal are influenced by its surroundings. New research led by the University of Otago – Ōtākou Whakaihu Waka describes a new, extinct shelduck whose ancestors arrived on the islands 390,000 years ago. While this may seem […]
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