Admin's articles Biology SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked Life Sciences DNA from the deep reveals a hidden ocean “superhighway” A world-first study led by Museums Victoria Research Institute has revealed that beneath the cold, dark, pressurized world of the deep sea, marine life is far more globally connected than previously imagined. Published on July 23 in Nature, this landmark study maps the global distribution and evolutionary relationships of brittle stars (Ophiuroidea), the ancient, spiny animals […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked Life Sciences Scientists just cracked the code to editing entire chromosomes flawlessly A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […] Written by Admin August 7, 2025August 7, 2025 Saving Bookmark this article Bookmarked Life Sciences Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed A new analysis of the bite strength of 18 species of carnivorous dinosaurs shows that while the Tyrannasaurus rex skull was optimized for quick, strong bites like a crocodile, other giant, predatory dinosaurs that walked on two legs — including spinosaurs and allosaurs — had much weaker bites and instead specialized in slashing and ripping […] Written by Admin August 6, 2025August 6, 2025 Saving Bookmark this article Bookmarked Life Sciences Scientists reexamine 47-year-old fossil and discover a new Jurassic sea monster Paleontologists have identified a new species of ancient marine reptile from Germany’s world-renowned Posidonia Shale fossil beds, expanding our understanding of prehistoric ocean ecosystems that existed nearly 183 million years ago. The newly classified species, named Plesionectes longicollum (“long-necked near-swimmer”), represents a previously unknown type of plesiosauroid — the group of long-necked marine reptiles that […] Written by Admin August 5, 2025August 5, 2025 Saving Bookmark this article Bookmarked Biology Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube In this issue, Kim et al. (https://doi.org/10.1083/jcb.202409078) report that the scaffold protein Arc acts through Crumbs to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Drosophila salivary gland. This restriction is needed for a long, thin tube to form. Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.6c6cd317.1754300369.4e0a6554 Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked Life Sciences Your nature photo might be a scientific breakthrough in disguise A frog croaks from a walking trail. A hiker snaps a photo and uploads it to iNaturalist. That single act — one person, one amphibian and one click — feeds into a growing global dataset that scientists now use to map shifting species ranges, detect invasive threats and even discover new species. An international study […] Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked Life Sciences 700,000 years ahead of their teeth: The carbs that made us human As early humans spread from lush African forests into grasslands, their need for ready sources of energy led them to develop a taste for grassy plants, especially grains and the starchy plant tissue hidden underground. But a new Dartmouth-led study shows that hominins began feasting on these carbohydrate-rich foods before they had the ideal teeth […] Written by Admin August 3, 2025August 3, 2025 Saving Bookmark this article Bookmarked Life Sciences How AI is supercharging plant immunity to fight deadly bacteria Scientists at the University of California, Davis, used artificial intelligence to help plants recognize a wider range of bacterial threats — which may lead to new ways to protect crops like tomatoes and potatoes from devastating diseases. The study was published in Nature Plants. Plants, like animals, have immune systems. Part of their defense toolkit […] Written by Admin August 2, 2025August 2, 2025 Saving Bookmark this article Bookmarked Life Sciences Koalas on the brink: Precision DNA test offers a lifeline to Australia’s icons A University of Queensland-led project has developed a tool to standardize genetic testing of koala populations, providing a significant boost to conservation and recovery efforts. Dr Lyndal Hulse from UQ’s School of the Environment said the standardized koala genetic marker panel provides a consistent method for researchers nationwide to capture and share koala genetic variation, […] Written by Admin August 1, 2025August 1, 2025 Saving Bookmark this article Bookmarked Biology AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact Membrane contact sites (MCSs) establish organelle interactomes in cells to enable communication and exchange of materials. Volume EM (vEM) is ideally suited for MCS analyses, but semantic segmentation of large vEM datasets remains challenging. Recent adoption of artificial intelligence (AI) for segmentation has greatly enhanced our analysis capabilities. However, we show that organelle boundaries, which […] Written by Admin July 31, 2025July 31, 2025 Saving Bookmark this article Bookmarked Loading Load more
Biology SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Life Sciences DNA from the deep reveals a hidden ocean “superhighway” A world-first study led by Museums Victoria Research Institute has revealed that beneath the cold, dark, pressurized world of the deep sea, marine life is far more globally connected than previously imagined. Published on July 23 in Nature, this landmark study maps the global distribution and evolutionary relationships of brittle stars (Ophiuroidea), the ancient, spiny animals […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Life Sciences Scientists just cracked the code to editing entire chromosomes flawlessly A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […] Written by Admin August 7, 2025August 7, 2025 Saving Bookmark this article Bookmarked
Life Sciences Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed A new analysis of the bite strength of 18 species of carnivorous dinosaurs shows that while the Tyrannasaurus rex skull was optimized for quick, strong bites like a crocodile, other giant, predatory dinosaurs that walked on two legs — including spinosaurs and allosaurs — had much weaker bites and instead specialized in slashing and ripping […] Written by Admin August 6, 2025August 6, 2025 Saving Bookmark this article Bookmarked
Life Sciences Scientists reexamine 47-year-old fossil and discover a new Jurassic sea monster Paleontologists have identified a new species of ancient marine reptile from Germany’s world-renowned Posidonia Shale fossil beds, expanding our understanding of prehistoric ocean ecosystems that existed nearly 183 million years ago. The newly classified species, named Plesionectes longicollum (“long-necked near-swimmer”), represents a previously unknown type of plesiosauroid — the group of long-necked marine reptiles that […] Written by Admin August 5, 2025August 5, 2025 Saving Bookmark this article Bookmarked
Biology Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube In this issue, Kim et al. (https://doi.org/10.1083/jcb.202409078) report that the scaffold protein Arc acts through Crumbs to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Drosophila salivary gland. This restriction is needed for a long, thin tube to form. Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.6c6cd317.1754300369.4e0a6554 Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked
Life Sciences Your nature photo might be a scientific breakthrough in disguise A frog croaks from a walking trail. A hiker snaps a photo and uploads it to iNaturalist. That single act — one person, one amphibian and one click — feeds into a growing global dataset that scientists now use to map shifting species ranges, detect invasive threats and even discover new species. An international study […] Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked
Life Sciences 700,000 years ahead of their teeth: The carbs that made us human As early humans spread from lush African forests into grasslands, their need for ready sources of energy led them to develop a taste for grassy plants, especially grains and the starchy plant tissue hidden underground. But a new Dartmouth-led study shows that hominins began feasting on these carbohydrate-rich foods before they had the ideal teeth […] Written by Admin August 3, 2025August 3, 2025 Saving Bookmark this article Bookmarked
Life Sciences How AI is supercharging plant immunity to fight deadly bacteria Scientists at the University of California, Davis, used artificial intelligence to help plants recognize a wider range of bacterial threats — which may lead to new ways to protect crops like tomatoes and potatoes from devastating diseases. The study was published in Nature Plants. Plants, like animals, have immune systems. Part of their defense toolkit […] Written by Admin August 2, 2025August 2, 2025 Saving Bookmark this article Bookmarked
Life Sciences Koalas on the brink: Precision DNA test offers a lifeline to Australia’s icons A University of Queensland-led project has developed a tool to standardize genetic testing of koala populations, providing a significant boost to conservation and recovery efforts. Dr Lyndal Hulse from UQ’s School of the Environment said the standardized koala genetic marker panel provides a consistent method for researchers nationwide to capture and share koala genetic variation, […] Written by Admin August 1, 2025August 1, 2025 Saving Bookmark this article Bookmarked
Biology AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact Membrane contact sites (MCSs) establish organelle interactomes in cells to enable communication and exchange of materials. Volume EM (vEM) is ideally suited for MCS analyses, but semantic segmentation of large vEM datasets remains challenging. Recent adoption of artificial intelligence (AI) for segmentation has greatly enhanced our analysis capabilities. However, we show that organelle boundaries, which […] Written by Admin July 31, 2025July 31, 2025 Saving Bookmark this article Bookmarked
