Admin's articles Biology RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking Post-Golgi exocytic trafficking, fundamental for secretion and cell surface component integration, remains incompletely understood at the molecular level. Here, we investigated this process using Caenorhabditis elegans and mammalian cell models, revealing a novel exocytic carrier capturing mechanism involving the small GTPase RAB-10/Rab10 and its effector EHBP-1/EHBP1. EHBP-1, localized in recycling endosomes, selectively captures RAB-10-positive lipoprotein […] Written by Admin February 22, 2025February 22, 2025 Saving Bookmark this article Bookmarked Life Sciences Researchers outline new approach for better understanding animal consciousness A team of researchers has outlined a new approach for better understanding the depths of animal consciousness, a method that may yield new insights into the similarities and differences among living organisms. The essay, which appears in the journal Science, describes a “marker method” that scientists can use to assess animal consciousness. It involves identifying […] Written by Admin February 21, 2025February 21, 2025 Saving Bookmark this article Bookmarked Life Sciences Urban environments promote adaptation to multiple stressors Animal populations from urban areas show significantly higher resilience to stressful environmental conditions. This was found by an international team of researchers led by Dr Elizabeta Briski from the GEOMAR Helmholtz Centre for Ocean Research Kiel, Germany. The mussel and crustacean species studied were able to adapt to disturbed environments, making them more resistant to […] Written by Admin February 20, 2025February 20, 2025 Saving Bookmark this article Bookmarked Life Sciences Wild fish can recognize individual divers For years, scientific divers at a research station in the Mediterranean Sea had a problem: at some point in every field season, local fish would follow them and steal food intended as experimental rewards. Intriguingly these wild fish appeared to recognize the specific diver who had previously carried food, choosing to follow only them while […] Written by Admin February 19, 2025February 19, 2025 Saving Bookmark this article Bookmarked Biology Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation The process of folding the flat neuroectoderm into an elongated neural tube depends on tissue fluidity, a property that allows epithelial deformation while preserving tissue integrity. Neural tube folding also requires the planar cell polarity (PCP) pathway. Here, we report that Prickle2 (Pk2), a core PCP component, increases tissue fluidity by promoting the remodeling of […] Written by Admin February 18, 2025February 18, 2025 Saving Bookmark this article Bookmarked Life Sciences Researchers discover how opsin 3, a light-sensitive brain protein, regulates food consumption in mice Scientists discovered years ago that the hypothalamus — which helps to manage body temperature, hunger, sex drive, sleep and more — includes neurons that express the protein opsin 3 (OPN3). Far less clear, however, was what this light-sensing protein does so deep inside the brain. A study published in PNAS suggests that OPN3 plays an […] Written by Admin February 18, 2025February 18, 2025 Saving Bookmark this article Bookmarked Life Sciences Guardian molecule keeps cells on track — new perspectives for the treatment of liver cancer A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the German Cancer Research Center (DKFZ), the Hector Institute für Translational Brain Research (HITBR), and from the European Molecular Biology Laboratory (EMBL). The discovery is of great interest for cancer medicine because a change of identity […] Written by Admin February 17, 2025February 17, 2025 Saving Bookmark this article Bookmarked Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1739781208.72b61e6 Written by Admin February 17, 2025February 17, 2025 Saving Bookmark this article Bookmarked Life Sciences Dessert stomach emerges in the brain To find the cause of the “dessert stomach,” the researchers investigated the reaction of mice to sugar and found that completely satiated mice still ate desserts. Investigations of the brain showed that a group of nerve cells, the so-called POMC neurones, are responsible for this. These neurones become active as soon as the mice were […] Written by Admin February 16, 2025February 16, 2025 Saving Bookmark this article Bookmarked Life Sciences Marine mystery solved: How anemonefish avoid stings from their sea anemone hosts The clownfish-anemone living arrangement is one of the most widely recognized examples of symbiosis. Researchers have made a breakthrough in understanding how anemonefish can live safely among sea anemones without being stung by their venomous tentacles, solving a century-long mystery. Scientists at the Okinawa Institute of Science and Technology (OIST) and their international collaborators have […] Written by Admin February 15, 2025February 15, 2025 Saving Bookmark this article Bookmarked Biology An S-acylated N-terminus and a conserved loop regulate the activity of the ABHD17 deacylase The dynamic addition and removal of long-chain fatty acids modulate protein function and localization. The α/β hydrolase domain–containing (ABHD) 17 enzymes remove acyl chains from membrane-localized proteins such as the oncoprotein NRas, but how the ABHD17 proteins are regulated is unknown. Here, we used cell-based studies and molecular dynamics simulations to show that ABHD17 activity […] Written by Admin February 15, 2025February 15, 2025 Saving Bookmark this article Bookmarked Life Sciences Global warming and mass extinctions: What we can learn from plants from the last ice age Global warming is producing a rapid loss of plant species — according to estimates, roughly 600 plant species have died out since 1750 — twice the number of animal species lost. But which species are hit hardest? And how does altered biodiversity actually affect interactions between plants? Experts from the Alfred Wegener Institute have tackled […] Written by Admin February 13, 2025February 13, 2025 Saving Bookmark this article Bookmarked Loading Load more
Biology RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking Post-Golgi exocytic trafficking, fundamental for secretion and cell surface component integration, remains incompletely understood at the molecular level. Here, we investigated this process using Caenorhabditis elegans and mammalian cell models, revealing a novel exocytic carrier capturing mechanism involving the small GTPase RAB-10/Rab10 and its effector EHBP-1/EHBP1. EHBP-1, localized in recycling endosomes, selectively captures RAB-10-positive lipoprotein […] Written by Admin February 22, 2025February 22, 2025 Saving Bookmark this article Bookmarked
Life Sciences Researchers outline new approach for better understanding animal consciousness A team of researchers has outlined a new approach for better understanding the depths of animal consciousness, a method that may yield new insights into the similarities and differences among living organisms. The essay, which appears in the journal Science, describes a “marker method” that scientists can use to assess animal consciousness. It involves identifying […] Written by Admin February 21, 2025February 21, 2025 Saving Bookmark this article Bookmarked
Life Sciences Urban environments promote adaptation to multiple stressors Animal populations from urban areas show significantly higher resilience to stressful environmental conditions. This was found by an international team of researchers led by Dr Elizabeta Briski from the GEOMAR Helmholtz Centre for Ocean Research Kiel, Germany. The mussel and crustacean species studied were able to adapt to disturbed environments, making them more resistant to […] Written by Admin February 20, 2025February 20, 2025 Saving Bookmark this article Bookmarked
Life Sciences Wild fish can recognize individual divers For years, scientific divers at a research station in the Mediterranean Sea had a problem: at some point in every field season, local fish would follow them and steal food intended as experimental rewards. Intriguingly these wild fish appeared to recognize the specific diver who had previously carried food, choosing to follow only them while […] Written by Admin February 19, 2025February 19, 2025 Saving Bookmark this article Bookmarked
Biology Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation The process of folding the flat neuroectoderm into an elongated neural tube depends on tissue fluidity, a property that allows epithelial deformation while preserving tissue integrity. Neural tube folding also requires the planar cell polarity (PCP) pathway. Here, we report that Prickle2 (Pk2), a core PCP component, increases tissue fluidity by promoting the remodeling of […] Written by Admin February 18, 2025February 18, 2025 Saving Bookmark this article Bookmarked
Life Sciences Researchers discover how opsin 3, a light-sensitive brain protein, regulates food consumption in mice Scientists discovered years ago that the hypothalamus — which helps to manage body temperature, hunger, sex drive, sleep and more — includes neurons that express the protein opsin 3 (OPN3). Far less clear, however, was what this light-sensing protein does so deep inside the brain. A study published in PNAS suggests that OPN3 plays an […] Written by Admin February 18, 2025February 18, 2025 Saving Bookmark this article Bookmarked
Life Sciences Guardian molecule keeps cells on track — new perspectives for the treatment of liver cancer A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the German Cancer Research Center (DKFZ), the Hector Institute für Translational Brain Research (HITBR), and from the European Molecular Biology Laboratory (EMBL). The discovery is of great interest for cancer medicine because a change of identity […] Written by Admin February 17, 2025February 17, 2025 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1739781208.72b61e6 Written by Admin February 17, 2025February 17, 2025 Saving Bookmark this article Bookmarked
Life Sciences Dessert stomach emerges in the brain To find the cause of the “dessert stomach,” the researchers investigated the reaction of mice to sugar and found that completely satiated mice still ate desserts. Investigations of the brain showed that a group of nerve cells, the so-called POMC neurones, are responsible for this. These neurones become active as soon as the mice were […] Written by Admin February 16, 2025February 16, 2025 Saving Bookmark this article Bookmarked
Life Sciences Marine mystery solved: How anemonefish avoid stings from their sea anemone hosts The clownfish-anemone living arrangement is one of the most widely recognized examples of symbiosis. Researchers have made a breakthrough in understanding how anemonefish can live safely among sea anemones without being stung by their venomous tentacles, solving a century-long mystery. Scientists at the Okinawa Institute of Science and Technology (OIST) and their international collaborators have […] Written by Admin February 15, 2025February 15, 2025 Saving Bookmark this article Bookmarked
Biology An S-acylated N-terminus and a conserved loop regulate the activity of the ABHD17 deacylase The dynamic addition and removal of long-chain fatty acids modulate protein function and localization. The α/β hydrolase domain–containing (ABHD) 17 enzymes remove acyl chains from membrane-localized proteins such as the oncoprotein NRas, but how the ABHD17 proteins are regulated is unknown. Here, we used cell-based studies and molecular dynamics simulations to show that ABHD17 activity […] Written by Admin February 15, 2025February 15, 2025 Saving Bookmark this article Bookmarked
Life Sciences Global warming and mass extinctions: What we can learn from plants from the last ice age Global warming is producing a rapid loss of plant species — according to estimates, roughly 600 plant species have died out since 1750 — twice the number of animal species lost. But which species are hit hardest? And how does altered biodiversity actually affect interactions between plants? Experts from the Alfred Wegener Institute have tackled […] Written by Admin February 13, 2025February 13, 2025 Saving Bookmark this article Bookmarked
