Admin's articles Life Sciences Genes linked to deadly parasites’ spread beyond Africa identified The findings reveal that climate change and measures to control populations of tsetse flies, which carry the disease, may drive molecular changes in the organisms that cause sleeping sickness — which can be fatal if left untreated. The parasites — known as African trypanosomes — are normally transmitted by tsetse flies in sub-Saharan Africa. However, […] Written by Admin December 20, 2024December 20, 2024 Saving Bookmark this article Bookmarked Biology A proteome-wide yeast degron collection for the dynamic study of protein function Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out. Specifically, libraries that involve a cellular perturbation, such as the deletion collection, have facilitated key biological discoveries. However, short-term rewiring and long-term accumulation of suppressor mutations often obscure the functional consequences of such perturbations. We present the AID library […] Written by Admin December 19, 2024December 19, 2024 Saving Bookmark this article Bookmarked Life Sciences Conserving high-elevation grasslands in Peru is key to protect Andean bears Andean bears carefully select the best foraging locations and plants to maximize nutrition and avoid livestock, according to a study publishing December 18, 2024, in the open-access journal PLOS ONE by Nicholas Pilfold at the San Diego Zoo Wildlife Alliance in California, U.S., and colleagues. Andean bears, also known as ‘spectacled bears’ because of the […] Written by Admin December 19, 2024December 19, 2024 Saving Bookmark this article Bookmarked Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1734595969.1f24c1d Written by Admin December 19, 2024December 19, 2024 Saving Bookmark this article Bookmarked Life Sciences Is fake meat good to eat? Processed plant-based meat alternatives linked to depression risk in vegetarians There is mounting evidence suggesting that ultra processed foods (UPF) are bad for our health; but if you stick to a vegetarian diet, is that still the case? Plant-Based Meat Alternatives (PBMA) are considered to be ultra-processed foods and may be associated with similar harms. In the first study of its kind, published in Food […] Written by Admin December 18, 2024December 18, 2024 Saving Bookmark this article Bookmarked Biology SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe acute respiratory syndrome coronavirus (SARS-CoV) exhibit differences in their inflammatory responses and pulmonary damage, yet the specific mechanisms remain unclear. Here, we discovered that the SARS-CoV-2 nucleocapsid (N) protein inhibits the activation of the nuclear factor-κB (NF-κB) pathway and downstream signal transduction by impeding the assembly […] Written by Admin December 18, 2024December 18, 2024 Saving Bookmark this article Bookmarked Life Sciences Threat of abrupt mortality events keeps endangered monkey population at risk, despite decades of growth Despite the population being almost four times larger than it was in 1982, a new study published in the journal Ecology suggests the northern muriqui monkeys remain at risk, especially in the face of ongoing habitat disturbances. Northern muriquis, which live in the Atlantic Forest of Brazil, are much more peaceful and egalitarian compared to […] Written by Admin December 17, 2024December 17, 2024 Saving Bookmark this article Bookmarked Life Sciences Hippos ‘vulnerable’ as gaps in data hinder conservation efforts A new database of African hippo populations has revealed huge gaps in our knowledge of where the megaherbivores live and thrive, with populations fragmented and reliant on protected areas. Hippos are classified as “vulnerable to extinction” by the International Union for the Conservation of Nature (IUCN) Red List and have been called the “neglected megafauna,” […] Written by Admin December 16, 2024December 16, 2024 Saving Bookmark this article Bookmarked Life Sciences Climate and land use change threaten traditional food sources in Russia’s Far East The distribution of traditional wild food sources in the Republic of Sakha could change significantly, affecting the diets and incomes of Indigenous rural communities who depend on them. Climate- and land use change could significantly alter the make-up and availability of wild traditional foods in the vast Russian Far East, a region that is home […] Written by Admin December 15, 2024December 15, 2024 Saving Bookmark this article Bookmarked Life Sciences A new twist: The molecular machines that loop our chromosomes also twist DNA Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they now discovered that these motors also put significant twists […] Written by Admin December 14, 2024December 14, 2024 Saving Bookmark this article Bookmarked Life Sciences Overfishing has halved shark and ray populations since 1970 A new analysis published in the journal Science reveals that overfishing has caused populations of chondrichthyan fishes — sharks, rays, and chimaeras — to decline by more than 50 per cent since 1970. To determine the consequences, a team of researchers developed an aquatic Red List Index (RLI) which shows that the risk of extinction […] Written by Admin December 13, 2024December 13, 2024 Saving Bookmark this article Bookmarked Biology An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis Precisely controlled remodeling of the basement membrane (BM) is crucial for morphogenesis, but its molecular and tissue-level dynamics, underlying mechanisms, and functional significance in mammals remain largely unknown due to limited visualization tools. We developed mouse lines in which the endogenous collagen IV gene (Col4a2) was fused with a fluorescent tag. Through live imaging of […] Written by Admin December 12, 2024December 12, 2024 Saving Bookmark this article Bookmarked Loading Load more
Life Sciences Genes linked to deadly parasites’ spread beyond Africa identified The findings reveal that climate change and measures to control populations of tsetse flies, which carry the disease, may drive molecular changes in the organisms that cause sleeping sickness — which can be fatal if left untreated. The parasites — known as African trypanosomes — are normally transmitted by tsetse flies in sub-Saharan Africa. However, […] Written by Admin December 20, 2024December 20, 2024 Saving Bookmark this article Bookmarked
Biology A proteome-wide yeast degron collection for the dynamic study of protein function Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out. Specifically, libraries that involve a cellular perturbation, such as the deletion collection, have facilitated key biological discoveries. However, short-term rewiring and long-term accumulation of suppressor mutations often obscure the functional consequences of such perturbations. We present the AID library […] Written by Admin December 19, 2024December 19, 2024 Saving Bookmark this article Bookmarked
Life Sciences Conserving high-elevation grasslands in Peru is key to protect Andean bears Andean bears carefully select the best foraging locations and plants to maximize nutrition and avoid livestock, according to a study publishing December 18, 2024, in the open-access journal PLOS ONE by Nicholas Pilfold at the San Diego Zoo Wildlife Alliance in California, U.S., and colleagues. Andean bears, also known as ‘spectacled bears’ because of the […] Written by Admin December 19, 2024December 19, 2024 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1734595969.1f24c1d Written by Admin December 19, 2024December 19, 2024 Saving Bookmark this article Bookmarked
Life Sciences Is fake meat good to eat? Processed plant-based meat alternatives linked to depression risk in vegetarians There is mounting evidence suggesting that ultra processed foods (UPF) are bad for our health; but if you stick to a vegetarian diet, is that still the case? Plant-Based Meat Alternatives (PBMA) are considered to be ultra-processed foods and may be associated with similar harms. In the first study of its kind, published in Food […] Written by Admin December 18, 2024December 18, 2024 Saving Bookmark this article Bookmarked
Biology SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and severe acute respiratory syndrome coronavirus (SARS-CoV) exhibit differences in their inflammatory responses and pulmonary damage, yet the specific mechanisms remain unclear. Here, we discovered that the SARS-CoV-2 nucleocapsid (N) protein inhibits the activation of the nuclear factor-κB (NF-κB) pathway and downstream signal transduction by impeding the assembly […] Written by Admin December 18, 2024December 18, 2024 Saving Bookmark this article Bookmarked
Life Sciences Threat of abrupt mortality events keeps endangered monkey population at risk, despite decades of growth Despite the population being almost four times larger than it was in 1982, a new study published in the journal Ecology suggests the northern muriqui monkeys remain at risk, especially in the face of ongoing habitat disturbances. Northern muriquis, which live in the Atlantic Forest of Brazil, are much more peaceful and egalitarian compared to […] Written by Admin December 17, 2024December 17, 2024 Saving Bookmark this article Bookmarked
Life Sciences Hippos ‘vulnerable’ as gaps in data hinder conservation efforts A new database of African hippo populations has revealed huge gaps in our knowledge of where the megaherbivores live and thrive, with populations fragmented and reliant on protected areas. Hippos are classified as “vulnerable to extinction” by the International Union for the Conservation of Nature (IUCN) Red List and have been called the “neglected megafauna,” […] Written by Admin December 16, 2024December 16, 2024 Saving Bookmark this article Bookmarked
Life Sciences Climate and land use change threaten traditional food sources in Russia’s Far East The distribution of traditional wild food sources in the Republic of Sakha could change significantly, affecting the diets and incomes of Indigenous rural communities who depend on them. Climate- and land use change could significantly alter the make-up and availability of wild traditional foods in the vast Russian Far East, a region that is home […] Written by Admin December 15, 2024December 15, 2024 Saving Bookmark this article Bookmarked
Life Sciences A new twist: The molecular machines that loop our chromosomes also twist DNA Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they now discovered that these motors also put significant twists […] Written by Admin December 14, 2024December 14, 2024 Saving Bookmark this article Bookmarked
Life Sciences Overfishing has halved shark and ray populations since 1970 A new analysis published in the journal Science reveals that overfishing has caused populations of chondrichthyan fishes — sharks, rays, and chimaeras — to decline by more than 50 per cent since 1970. To determine the consequences, a team of researchers developed an aquatic Red List Index (RLI) which shows that the risk of extinction […] Written by Admin December 13, 2024December 13, 2024 Saving Bookmark this article Bookmarked
Biology An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis Precisely controlled remodeling of the basement membrane (BM) is crucial for morphogenesis, but its molecular and tissue-level dynamics, underlying mechanisms, and functional significance in mammals remain largely unknown due to limited visualization tools. We developed mouse lines in which the endogenous collagen IV gene (Col4a2) was fused with a fluorescent tag. Through live imaging of […] Written by Admin December 12, 2024December 12, 2024 Saving Bookmark this article Bookmarked
