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Securin regulates the spatiotemporal dynamics of separase

Separase regulates multiple aspects of the metaphase-to-anaphase transition. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to promote exocytosis. The anaphase-promoting complex/cyclosome (APC/C) activates separase by ubiquitinating its inhibitory chaperone, securin, triggering its degradation. How this pathway controls the exocytic function of separase is unknown. During meiosis I, securin is degraded over […]
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What Role Can Climate Change Play in the Courtroom? – State of the Planet

Columbia’s Sabin Center for Climate Change Law focuses on four program areas: cross-cutting issues and initiatives, energy law, environmental and land use law, and international and foreign law. As the number of legal efforts involving each of these categories continues to grow, the center has positioned itself as a resource hub for tracking and analyzing […]
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Explore the Future of Healthcare: 8 Transformative Trends

The healthcare landscape is undergoing a significant transformation driven by technological advancements and evolving medical knowledge. Over the past few years, we’ve identified eight key trends that will profoundly reshape healthcare delivery. While we’ve discussed these trends individually in previous posts, this article aims to provide a comprehensive overview, benefiting both healthcare professionals and users. […]
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The Importance of Introducing Science to Children from an Early Age
  1. Blog

The Importance of Introducing Science to Children from an Early Age

lifesciencenews.info – Science is systematic knowledge about nature and the physical world which discusses physics, chemistry, botany, zoology, geology, and so on. In everyday life, science has a direct and indirect influence. Apart from that, science also provides many benefits in life. Therefore, it is not surprising that science is one of the mandatory subjects […]
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  1. Blog

Harinarayan Gopichandran Welcomed as Vice President, Technical Solutions at PointCross Life Sciences

PointCross Life Sciences is pleased to announce the appointment of Harinarayan Gopichandran as Vice President, Technical Solutions, marking a significant addition to its leadership team. Hari’s extensive background in statistical programming, gained through roles at Icon Clinical Research, Novartis, Allergan, Cognizant, and Saama, positions him as a notable figure in the industry. In his new […]
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Six bispecific antibody companies you should know about
  1. Biotechnology

Six bispecific antibody companies you should know about

Bispecific antibodies seem to be all the rage at the minute. Their ability to deliver targeted therapeutics to patients with a two-in-one approach by simultaneously binding to two different antigens or epitopes makes them an extremely attractive proposition to drug developers. This can be seen in the fact that there have been multiple big buyouts […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Scientists recreate mouse from gene older than animal life

Published in Nature Communications, an international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals. This breakthrough reshapes our understanding of the genetic origins of stem […]
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  1. Pharmaceuticals and Drug Development

VU Researchers Publish Study on the Mechanism of CRISPR-Cas “Protein Scissors” in Molecular Cell

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, also known as DNA or gene ‘scissors’, which have revolutionized the field of genome editing, enabling scientists to […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

New model can help understand coexistence in nature

Different species of seabirds can coexist on small, isolated islands despite eating the same kind of fish. A researcher at Uppsala University has been involved in developing a mathematical model that can be used to better understand how this ecosystem works. “Our model shows that coexistence occurs naturally when species differ in their ability to […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Scientists recreate mouse from gene older than animal life

Published in Nature Communications, an international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals. This breakthrough reshapes our understanding of the genetic origins of stem […]
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  1. Biology

Securin regulates the spatiotemporal dynamics of separase

Separase regulates multiple aspects of the metaphase-to-anaphase transition. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to promote exocytosis. The anaphase-promoting complex/cyclosome (APC/C) activates separase by ubiquitinating its inhibitory chaperone, securin, triggering its degradation. How this pathway controls the exocytic function of separase is unknown. During meiosis I, securin is degraded over […]
Written by
  1. Environmental Science

What Role Can Climate Change Play in the Courtroom? – State of the Planet

Columbia’s Sabin Center for Climate Change Law focuses on four program areas: cross-cutting issues and initiatives, energy law, environmental and land use law, and international and foreign law. As the number of legal efforts involving each of these categories continues to grow, the center has positioned itself as a resource hub for tracking and analyzing […]
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  1. Biology

Securin regulates the spatiotemporal dynamics of separase

Separase regulates multiple aspects of the metaphase-to-anaphase transition. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to promote exocytosis. The anaphase-promoting complex/cyclosome (APC/C) activates separase by ubiquitinating its inhibitory chaperone, securin, triggering its degradation. How this pathway controls the exocytic function of separase is unknown. During meiosis I, securin is degraded over […]
Written by
  1. Environmental Science

What Role Can Climate Change Play in the Courtroom? – State of the Planet

Columbia’s Sabin Center for Climate Change Law focuses on four program areas: cross-cutting issues and initiatives, energy law, environmental and land use law, and international and foreign law. As the number of legal efforts involving each of these categories continues to grow, the center has positioned itself as a resource hub for tracking and analyzing […]
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