Pharmaceuticals and Drug Development

  1. Pharmaceuticals and Drug Development

New therapy that targets and destroys tau tangles is a promising future Alzheimer’s disease treatment

The team of scientists, from the Medical Research Council Laboratory of Molecular Biology (MRC LMB) in Cambridge, UK, and the UK Dementia Research Institute (UK DRI) at the University of Cambridge, say this promising approach could also be applied in future to other brain disorders driven by protein aggregation inside cells, such as motor neuron […]
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  1. Pharmaceuticals and Drug Development

Scholar Rock Submits Biologics License Application (BLA) to the U.S. FDA for Apitegromab as a Treatment for Patients with Spinal Muscular Atrophy (SMA)

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Jan. 29, 2025– Scholar Rock (NASDAQ: SRRK), a late-stage biopharmaceutical company focused on advancing innovative treatments for spinal muscular atrophy (SMA), cardiometabolic disorders, and other serious…
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  1. Pharmaceuticals and Drug Development

Innovative Trials CEO named top Woman in Pharma at the Pharma Industry Awards UK

Speaking about her win, Shaw said: “It’s truly humbling to be recognized by my peers in this way. The calibre of competition, not just for the Woman in Pharma award, but across all award categories, was exceptionally high. Congratulations to everyone who was shortlisted for a UK Pharma Industry Award and particularly all the deserving […]
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  1. Pharmaceuticals and Drug Development

Three new life science start-ups thrive at Discovery Park

The new businesses are all contract research organisations, namely Biowaived, Matheus Engineering and Particology Ltd. Their launch has been supported by Pfizer’s Pharmaceutical Sciences Small Molecule (PSSM) division, with contracts for work to build their initial viability and momentum. The opportunity to establish these new businesses emerged from Pfizer’s cost realignment programme over the past […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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