Biotechnology Tetraspecific B/NK cell better than T cell engagers The therapeutic landscape for relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL) is evolving toward targeted T-cell based immunotherapies, including CD19-targeted CAR-T and CD3xCD20 T-cell engaging (TCE) bispecificantibodies. Yet, there remains an unmet medical need for patients who are refractory to, or ineligible for these treatments. Leveraging natural killer NK cells emerges as a promising […] Written by Thomas Gabrielczyk November 16, 2024November 16, 2024 Saving Bookmark this article Bookmarked
AI-designed DNA controls genes in healthy mammalian cells for first time A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can […] Written by Admin May 8, 2025May 8, 2025 Saving Bookmark this article Bookmarked
CDK4/6 Inhibitors Boost First-Line Breast Cancer Therapy In an ambitious stride toward optimizing treatment for hormone receptor-positive (HR+)/HER2-negative advanced breast cancer, a recent comprehensive network meta-analysis has brought fresh insights into the comparative efficacy and safety of the four widely used CDK4/6 inhibitors combined with aromatase inhibitors (AI). Published in the upcoming 2025 volume of BMC Cancer, this pioneering study meticulously synthesizes […] Written by Bioengineer May 8, 2025May 8, 2025 Saving Bookmark this article Bookmarked
AI-designed DNA controls genes in healthy mammalian cells for first time A study published today in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can […] Written by Admin May 8, 2025May 8, 2025 Saving Bookmark this article Bookmarked
CDK4/6 Inhibitors Boost First-Line Breast Cancer Therapy In an ambitious stride toward optimizing treatment for hormone receptor-positive (HR+)/HER2-negative advanced breast cancer, a recent comprehensive network meta-analysis has brought fresh insights into the comparative efficacy and safety of the four widely used CDK4/6 inhibitors combined with aromatase inhibitors (AI). Published in the upcoming 2025 volume of BMC Cancer, this pioneering study meticulously synthesizes […] Written by Bioengineer May 8, 2025May 8, 2025 Saving Bookmark this article Bookmarked
All of the Biggest U.S. Cities Are Sinking – State of the Planet A new study of the 28 most populous U.S. cities finds that all are sinking to one degree or another. The cities include not just those on the coasts, where relative sea level is a concern, but many in the interior. Furthermore, using newly granular data, the study finds that some cities are sinking at […] Written by Kevin Krajick May 8, 2025May 8, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked
