Life Sciences Some benefits of exercise stem from the immune system The connection between exercise and inflammation has captivated the imagination of researchers ever since an early 20th-century study showed a spike of white cells in the blood of Boston marathon runners following the race. Now, a new Harvard Medical School study published Nov. 3 in Science Immunology may offer a molecular explanation behind this century-old […] Written by Admin November 4, 2023November 4, 2023 Saving Bookmark this article Bookmarked
BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways We identify BEACH domain–containing proteins (BDCPs) as novel membrane coat proteins involved in the sorting of transmembrane proteins (TMPs) on the trans-Golgi network and tubular sorting endosomes. The seven typical mammalian BDCPs share a predicted alpha-solenoid-beta propeller structure, suggesting they have a protocoatomer origin and function. We map the subcellular localization of seven BDCPs based […] Written by Admin November 10, 2024November 10, 2024 Saving Bookmark this article Bookmarked
35 Years of Harnessing the Power of Geospatial Data for Decision Making – State of the Planet The Climate School’s Center for International Earth Science Information Network (CIESIN) is celebrating its 35th year since its founding as an independent nonprofit in 1989, and its 25th year housed at Columbia University. These anniversaries come with another milestone: a new name. As of today, CIESIN will now stand for the Center for Integrated Earth […] Written by Francesco Fiondella November 10, 2024November 10, 2024 Saving Bookmark this article Bookmarked
BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways We identify BEACH domain–containing proteins (BDCPs) as novel membrane coat proteins involved in the sorting of transmembrane proteins (TMPs) on the trans-Golgi network and tubular sorting endosomes. The seven typical mammalian BDCPs share a predicted alpha-solenoid-beta propeller structure, suggesting they have a protocoatomer origin and function. We map the subcellular localization of seven BDCPs based […] Written by Admin November 10, 2024November 10, 2024 Saving Bookmark this article Bookmarked
35 Years of Harnessing the Power of Geospatial Data for Decision Making – State of the Planet The Climate School’s Center for International Earth Science Information Network (CIESIN) is celebrating its 35th year since its founding as an independent nonprofit in 1989, and its 25th year housed at Columbia University. These anniversaries come with another milestone: a new name. As of today, CIESIN will now stand for the Center for Integrated Earth […] Written by Francesco Fiondella November 10, 2024November 10, 2024 Saving Bookmark this article Bookmarked
New tentative approval for Alembic drug dabigatran etexilate mesylate Copyright © DrugPatentWatch. Originally published at https://www.drugpatentwatch.com/blog/ Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs. There are three patents protecting this compound. Drug patent litigation for DABIGATRAN ETEXILATE MESYLATE. Nine suppliers are […] Written by DrugPatentWatch – Make Better Decisions November 10, 2024November 10, 2024 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked