Gourmey

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Elevated levels of plasma-free fatty acids and oxidative stress have been identified as putative primary pathogenic factors in endothelial dysfunction etiology, though their roles are unclear. In human endothelial cells, we found that saturated fatty acids (SFAs)—including the plasma-predominant palmitic acid (PA)—cause mitochondrial fragmentation and elevation of intracellular reactive oxygen species (ROS) levels. TRPML1 is […]

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Elevated levels of plasma-free fatty acids and oxidative stress have been identified as putative primary pathogenic factors in endothelial dysfunction etiology, though their roles are unclear. In human endothelial cells, we found that saturated fatty acids (SFAs)—including the plasma-predominant palmitic acid (PA)—cause mitochondrial fragmentation and elevation of intracellular reactive oxygen species (ROS) levels. TRPML1 is […]
According to a new World Health Organization (WHO) report released on October 29, 2024, tuberculosis (TB) replaced COVID-19 to become the top cause of infectious disease-related deaths in 2023, as a total of 1.25 million people died from it last year. Additionally, 8.2 million people were newly diagnosed, up from 7.5 million in 2022. TB […]

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