life sciences

BioNtech reports Car-T/mRNA booster study results at ESMO
  1. Biotechnology

BioNtech reports Car-T/mRNA booster study results at ESMO

BioNtech SE has reported preliminary Phase I/II results with BNT211-01 (NEO-PTC-01) and CarVAC at ESMO conference in Madrid Testing different dose levels of its adoptive cell therapy BNT.221-01, a combination of Claudin 6 (CLDN6)-targeted Car-T cells (derived from NEO-PTC-01, initially developed by tody’s BioNTech subsidiary Neon Therapeutics) and the mRNA-based Car-T  booster CarVac (CAR-T cell […]
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Antiverse and GlobalBio Inc. extend collaboration
  1. Biotechnology

Antiverse and GlobalBio Inc. extend collaboration

Antiverse Ltd and GlobalBio Inc. have extend their cancer antibody partnership to progress two PD-1 modulators to preclinial development AI specialist Antiverse Ltd (Cardiff, UK) and antobody engeeniering expert GlobalBio, Inc. (New York, USA) will be extending their collaboration to advance immune checkpoint inhibitors in cancer therapy. The initial collaboration successfully resulted in the generation […]
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SpliceBio has made up a US $216m alliance with Spark Therapeutics
  1. Biotechnology

SpliceBio has made up a US $216m alliance with Spark Therapeutics

SpliceBio has licenced its intein technlogy to Roche’s gene therapy subsidiary Spark Therapeutics to develop a gene therapy targeting an undisclosed inherited retinal disease. Under a globally exclusive licence option agreement with Roche AG, SpliceBio secures an upfront payment, opt-in and milestone payments up to $216m plus royalties in exchange to its recombinant split […]
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Hematological and Biochemical Indices of a Local Rabbit…

Rabbit feed in Algeria is still based exclusively on commercial pelleted diets, but the recent use of non-conventional ingredients in feed formulation is becoming more frequent, and several studies were carried out on the incorporation of local raw materials in rabbit feed worldwide. However, studies related to the incorporation of Jujube are nonexistent. In this […]
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Worlwide

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Hematological and Biochemical Indices of a Local Rabbit…

Rabbit feed in Algeria is still based exclusively on commercial pelleted diets, but the recent use of non-conventional ingredients in feed formulation is becoming more frequent, and several studies were carried out on the incorporation of local raw materials in rabbit feed worldwide. However, studies related to the incorporation of Jujube are nonexistent. In this […]
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PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways

Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
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