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Novel genomic screening tool enables precision reverse-engineering of genetic programming in cells

Collaborative research led by investigators at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center defines a novel approach to understanding how certain proteins called transcription factors determine which genetic programs will drive cell growth and maturation. The method, called “Perturb-multiome,” uses CRISPR to knock out the function of individual transcription factors across many blood cells at […]
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