sino biological

Schematic diagram of CAR structure (Source: doi: 10.1186/s40364-017-0102-y)
  1. Biotechnology

A Universal Solution Emerges: Anti-Linker Antibodies Simplify CAR-T Detection and Development

The study reported significantly prolonged progression-free survival and a 44% improvement in overall survival. Recently, CAR-T has also shown great potential in treating autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis. However, CAR-T development has long faced a persistent challenge: each new CAR targeting a novel tumor antigen requires the iterative development of a fully validated […]
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Anti-payload Antibodies: Facilitating ADC PK studies
  1. Biotechnology

Anti-payload Antibodies: Facilitating ADC PK studies

Sino Biological has successfully developed anti-payload antibodies which are used for analyzing the plasma/serum PK profiles, DAR values, and drug load distribution of ADC drugs. Anti-payload antibodies are used to evaluate the safety and efficacy of ADC drugs in the preclinical and clinical stages, empowering the ADC drug development process. As a great partner for […]
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Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of […]
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Labour’s ‘deeply alarming’ attack on protest rights

British authorities have severely restricted the right to protest in contravention of their international human rights obligations, creating an environment in which peaceful dissent is increasingly treated as a criminal act, Human Rights Watch said in its latest report. ‘Silencing the Streets’: The Right to Protest Under Attack in the UK documents that the UK’s […]
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Worlwide

Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of […]
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Labour’s ‘deeply alarming’ attack on protest rights

British authorities have severely restricted the right to protest in contravention of their international human rights obligations, creating an environment in which peaceful dissent is increasingly treated as a criminal act, Human Rights Watch said in its latest report. ‘Silencing the Streets’: The Right to Protest Under Attack in the UK documents that the UK’s […]
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