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Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved and what is their functional significance in tissue morphogenesis and maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. […]

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Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved and what is their functional significance in tissue morphogenesis and maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. […]
The Palisades Fire in Los Angeles. Photo: CAL FIRE_Official In light of the recent Los Angeles fires, a 2023 Columbia Climate School and Headwaters Economics report on wildfire mitigation strategies provides valuable insight into what’s needed to reduce fire risk and how it might be done.  According to the report, wildfires have always occurred naturally […]

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