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Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
Flooding in Klodzku, Poland Photo: Jacek Halicki 2024 was the hottest year on record. Around the world, 151 unprecedented extreme weather events devastated countries around the planet, including heat waves in Japan and Iran, floods in Italy, Pakistan, Poland and Brazil, and typhoons in Vietnam and the Philippines. Massive sums of money are needed to […]

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Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
Flooding in Klodzku, Poland Photo: Jacek Halicki 2024 was the hottest year on record. Around the world, 151 unprecedented extreme weather events devastated countries around the planet, including heat waves in Japan and Iran, floods in Italy, Pakistan, Poland and Brazil, and typhoons in Vietnam and the Philippines. Massive sums of money are needed to […]
Researchers examined teeth and skulls of 99 extinct crocodylomorph species and 20 living crocodylian species to reconstruct their dietary ecology and identify characteristics that helped some groups persist through two mass extinctions. They discovered that one secret tocrocodylian longevity is their remarkably flexible lifestyles, both in what they eat and the habitat in which they […]

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