Life Sciences Misha lived in zoos, but the elephant’s tooth enamel helps reconstruct wildlife migrations Teeth recovered from a beloved zoo elephant that died in 2008 are helping University of Utah geologists develop a method for tracking the movements of large herbivores across landscapes, even for animals now extinct, such as mastodons and mammoths. Outlined in recently published findings, the technique analyzes isotope ratios of the element strontium (Sr), which […] Written by Admin March 17, 2025March 17, 2025 Saving Bookmark this article Bookmarked
PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […] Written by Admin April 17, 2025April 17, 2025 Saving Bookmark this article Bookmarked
Why Climate Finance Is Key To Fighting Climate Change – State of the Planet Flooding in Klodzku, Poland Photo: Jacek Halicki 2024 was the hottest year on record. Around the world, 151 unprecedented extreme weather events devastated countries around the planet, including heat waves in Japan and Iran, floods in Italy, Pakistan, Poland and Brazil, and typhoons in Vietnam and the Philippines. Massive sums of money are needed to […] Written by Renée Cho April 17, 2025April 17, 2025 Saving Bookmark this article Bookmarked
PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […] Written by Admin April 17, 2025April 17, 2025 Saving Bookmark this article Bookmarked
Why Climate Finance Is Key To Fighting Climate Change – State of the Planet Flooding in Klodzku, Poland Photo: Jacek Halicki 2024 was the hottest year on record. Around the world, 151 unprecedented extreme weather events devastated countries around the planet, including heat waves in Japan and Iran, floods in Italy, Pakistan, Poland and Brazil, and typhoons in Vietnam and the Philippines. Massive sums of money are needed to […] Written by Renée Cho April 17, 2025April 17, 2025 Saving Bookmark this article Bookmarked
Secret to crocodylian longevity | ScienceDaily Researchers examined teeth and skulls of 99 extinct crocodylomorph species and 20 living crocodylian species to reconstruct their dietary ecology and identify characteristics that helped some groups persist through two mass extinctions. They discovered that one secret tocrocodylian longevity is their remarkably flexible lifestyles, both in what they eat and the habitat in which they […] Written by Admin April 16, 2025April 16, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked