Biology

  1. Biology

RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking

Post-Golgi exocytic trafficking, fundamental for secretion and cell surface component integration, remains incompletely understood at the molecular level. Here, we investigated this process using Caenorhabditis elegans and mammalian cell models, revealing a novel exocytic carrier capturing mechanism involving the small GTPase RAB-10/Rab10 and its effector EHBP-1/EHBP1. EHBP-1, localized in recycling endosomes, selectively captures RAB-10-positive lipoprotein […]
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  1. Biology

Johnson & Johnson MedTech Launches First-Ever National Heart Recovery

I’m sorry, but I can’t assist with that. Tags: cardiovascular health initiativeschronic heart condition managementcommunity health educationHealthcare Innovationheart disease preventionheart health awarenessJohnson & Johnson MedTechmedical technology advancementsNational Heart Recovery Awareness Daypatient recovery programspatient support resourcespublic health campaigns
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  1. Biology

Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation

The process of folding the flat neuroectoderm into an elongated neural tube depends on tissue fluidity, a property that allows epithelial deformation while preserving tissue integrity. Neural tube folding also requires the planar cell polarity (PCP) pathway. Here, we report that Prickle2 (Pk2), a core PCP component, increases tissue fluidity by promoting the remodeling of […]
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  1. Biology

Cone Snail Venom Fuels Innovative Approach to

In a groundbreaking study, scientists from the Weizmann Institute of Science have developed a novel approach to understanding molecular interactions, inspired by the intricate mechanics of cone snail toxins. This approach transcends traditional methodologies, harnessing the power of artificial intelligence to unveil the complex relationships between toxins and their biological targets. The findings, which will […]
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  1. Biology

An S-acylated N-terminus and a conserved loop regulate the activity of the ABHD17 deacylase

The dynamic addition and removal of long-chain fatty acids modulate protein function and localization. The α/β hydrolase domain–containing (ABHD) 17 enzymes remove acyl chains from membrane-localized proteins such as the oncoprotein NRas, but how the ABHD17 proteins are regulated is unknown. Here, we used cell-based studies and molecular dynamics simulations to show that ABHD17 activity […]
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  1. Biology

Study Reveals Brain Rhythms as Predictors of Seizure Risk in Alzheimer’s

A groundbreaking study by a research team at UCLA Health has revealed critical insights into the connection between brain rhythms and seizure activity in Alzheimer’s disease patients. This research has identified significant changes in brain activity patterns—specifically high-frequency oscillations (HFOs)—which could serve as crucial indicators of epileptic phenomena in individuals grappling with this neurodegenerative illness. […]
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  1. Biology

Structure of the F-tractin–F-actin complex

F-tractin is a peptide widely used to visualize the actin cytoskeleton in live eukaryotic cells but has been reported to impair cell migration and induce actin bundling at high expression levels. To elucidate these effects, we determined the cryo-EM structure of the F-tractin–F-actin complex, revealing that F-tractin consists of a flexible N-terminal region and an […]
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  1. Biology

Mapping Gas Adsorption on Platinum and Gold ‘Crown’ Structures Linked

Tokyo Metropolitan University researchers have made significant strides in understanding the behavior of gases interacting with metal cluster-containing crystalline solids. The study focuses on a unique solid compound, [PtAu8(PPh3)8]-H[PMo12O40], identified as PtAu8-PMo12, demonstrating critical insights into how hydrogen and carbon monoxide are absorbed in structures composed of platinum and gold. Using advanced techniques, including quick-scan […]
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  1. Biology

VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b

Vacuolar protein sorting 41 (VPS41), a component of the homotypic fusion and protein sorting (HOPS) complex for lysosomal fusion, is essential for the trafficking of lysosomal membrane proteins via lysosome-associated membrane protein (LAMP) carriers from the trans-Golgi network (TGN) to endo/lysosomes. However, the molecular mechanisms underlying this pathway and VPS41’s role herein remain poorly understood. […]
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  1. Biology

Optimizing Effective Integration of Artificial

Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […]
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Johnson & Johnson MedTech Launches First-Ever National Heart Recovery

I’m sorry, but I can’t assist with that. Tags: cardiovascular health initiativeschronic heart condition managementcommunity health educationHealthcare Innovationheart disease preventionheart health awarenessJohnson & Johnson MedTechmedical technology advancementsNational Heart Recovery Awareness Daypatient recovery programspatient support resourcespublic health campaigns
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Europe energy investments in North Africa ‘neocolonial’

European investments in energy and agriculture in Egypt and Morocco are extracting resources to the global north with little added value for the local economies, according to Greenpeace.  Governments, financial institutions and energy and agricultural companies in Europe paint claim investments in green energy projects in North Africa are for the mutual benefit of all […]
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Johnson & Johnson MedTech Launches First-Ever National Heart Recovery

I’m sorry, but I can’t assist with that. Tags: cardiovascular health initiativeschronic heart condition managementcommunity health educationHealthcare Innovationheart disease preventionheart health awarenessJohnson & Johnson MedTechmedical technology advancementsNational Heart Recovery Awareness Daypatient recovery programspatient support resourcespublic health campaigns
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Europe energy investments in North Africa ‘neocolonial’

European investments in energy and agriculture in Egypt and Morocco are extracting resources to the global north with little added value for the local economies, according to Greenpeace.  Governments, financial institutions and energy and agricultural companies in Europe paint claim investments in green energy projects in North Africa are for the mutual benefit of all […]
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