Biology

  1. Biology

Submembrane liprin-α1 clusters spatially localize insulin granule fusion

Insulin granule fusion in pancreatic β cells localizes to where they contact the ECM of the islet capillaries. The mechanism(s) underpinning localization are unclear. Using glucose or high K+ stimulation or the global uncaging of Ca2+, we show granule fusion consistently focused to the β cell–ECM interface, suggesting a specific localization mechanism. We tested for […]
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  1. Biology

Craving, Relapse, and Childhood Trauma: A Network Study

In recent years, the global consciousness regarding drug addiction and relapse has expanded considerably, spotlighting the intricate psychological and environmental factors that shape these phenomena. A groundbreaking study published in the International Journal of Mental Health and Addiction by Zhuang, Song, Jin, and colleagues offers a nuanced exploration into the complex interplay between craving, relapse, […]
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  1. Biology

Aortic Valve Guides Umbilical Artery Catheter Placement

In the fast-evolving world of neonatal intensive care, the quest for safer, more efficient methods to monitor and treat our most fragile patients is relentless. A new study published in the Journal of Perinatology sheds light on a novel ultrasound-guided technique that may revolutionize the placement of umbilical artery catheters (UAC) in neonates. This method […]
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  1. Biology

Triglyceride-Glucose and Waist Circumference: Diabetes Risk Insights

In the rapidly evolving landscape of diabetes research, recent findings shed light on the intricate interplay between various metabolic indicators and their influence on diabetes risk. One of the most compelling studies highlighting these interactions comes from a national cohort investigation led by Shan, Liu, and Gao. This pioneering research delves into the significance of […]
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  1. Biology

Identification of organelle-specific autophagy regulators from tandem CRISPR screens

Autophagy is a conserved degradative process that promotes cellular homeostasis under stress conditions. Under nutrient starvation, autophagy is nonselective, promoting indiscriminate breakdown of cytosolic components. Conversely, selective autophagy is responsible for the specific turnover of damaged organelles. We hypothesized that selective autophagy may be regulated by signaling pathways distinct from those controlling starvation-induced autophagy, thereby […]
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  1. Biology

New Research Suggests Punitive Laws on Substance Use During Pregnancy Could

In recent years, the United States has witnessed a growing wave of legislative efforts aimed at addressing substance use among pregnant and postpartum individuals. Against this backdrop, a groundbreaking study conducted by researchers at Columbia University’s Mailman School of Public Health offers an in-depth examination of how different state legal frameworks impact maternal health outcomes. […]
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  1. Biology

Origin of chromosome 12 trisomy surge in human induced pluripotent stem cells

Trisomy 12 is the most common whole-chromosome abnormality in human pluripotent stem cells. Conventionally, this acquired aneuploidy is ascribed to a rare single-cell event followed by selective growth advantage. Instead, we show that trisomy 12 emerges simultaneously in a very high percentage of cells in critical transition passages. Mis-segregation and incorporation of chromosome 12 into […]
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  1. Biology

Mpox Virus Impact in SIVmac239-Infected Macaques

In the ever-evolving landscape of infectious diseases, the intersection of complex viral infections and immune-compromised hosts represents an urgent frontier in biomedical research. A groundbreaking study recently published in Nature Communications has provided unprecedented insights into how Mpox virus (formerly known as monkeypox virus) orchestrates multifaceted pathogenic mechanisms within immunodeficient hosts, specifically focusing on SIVmac239-infected […]
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  1. Biology

Intraflagellar transport selectivity occurs within the proximal portion of the trypanosome flagellum

Intraflagellar transport (IFT) trains move bidirectionally along the doublet microtubules (DMTs) of the axoneme within the flagellum. In Trypanosoma brucei, IFT trains predominantly associate with four of the nine DMTs. Using high-resolution microscopy, we reveal how this selective association is put in place. IFT proteins form a ring surrounding the 9 DMTs above the transition […]
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  1. Biology

Sarcocystis halieti DNA Found in Birds Across Europe

In a groundbreaking study that reshapes our understanding of avian parasitology, researchers have successfully detected the DNA of Sarcocystis halieti—a parasitic protozoan—in the bloodstreams of several bird species across Europe. This finding not only illuminates the complex interactions between parasites and avian hosts but also raises intriguing questions about ecological dynamics, host specificity, and the […]
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Scientists recreate life’s first step: Linking amino acids to RNA

Scientists recreate life’s first step: Linking amino acids to RNA

Chemists at UCL have shown how two of biology’s most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of life four billion years ago. Amino acids are the building blocks of proteins, the “workhorses” of life essential to nearly every living process. But proteins cannot replicate or […]
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Scientists recreate life’s first step: Linking amino acids to RNA

Scientists recreate life’s first step: Linking amino acids to RNA

Chemists at UCL have shown how two of biology’s most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of life four billion years ago. Amino acids are the building blocks of proteins, the “workhorses” of life essential to nearly every living process. But proteins cannot replicate or […]
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