Biology

  1. Biology

High-resolution mapping of the actin fusion focus reveals myosin V–dependent formin transport for aster formation

Many processes such as polarized growth and secretion require specific actin networks. In fungi, cell–cell fusion requires cell wall digestion mediated by local secretion of lytic enzymes. In Schizosaccharomyces pombe, the myosin V Myo52 transports enzyme-containing secretory vesicles on the actin fusion focus, an aster-like actin network assembled by the condensate-forming formin Fus1. The fusion […]
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  1. Biology

Dexmedetomidine Enhances Neurocognitive Recovery in Aged Mice

In a groundbreaking study published in BMC Neuroscience, researchers have unveiled the remarkable effects of dexmedetomidine pretreatment on neurocognitive recovery in aged mice following surgical procedures. This research, led by scientists Q. Zhang, S. Hao, and G. Wang, sheds light on the intricate mechanisms at play in the aging brain and their implications for enhancing […]
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  1. Biology

Is the Parkinson’s-associated protein TMEM175 a proton channel: Yay or nay?

The abnormal protein degradation implicated in the pathogenesis of Parkinson’s disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K+ channel, minimally permeable to H+.
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  1. Biology

Luedeking-Piret Model Advances Multi-Step mAb Forecasting

In the rapidly evolving landscape of biopharmaceutical manufacturing, monoclonal antibodies (mAbs) have surged to the forefront as indispensable therapeutic agents. Their complex production processes, however, pose significant engineering challenges, particularly in predicting yield and quality over multi-step production sequences. A recent groundbreaking study by Wang, Verma, Chiu, and colleagues, published in Communications Engineering in 2025, […]
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  1. Biology

Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis

Mitophagy transports mitochondria to lysosomes for degradation to maintain energy homeostasis, inflammation, and immunity. Here, we identify CipB, a type III secretion system (T3SS) effector from Chromobacterium violaceum, as a novel exogenous mitophagy receptor. CipB targets mitochondria by the mitochondrial protein TUFM and recruits autophagosomes via its LC3-interacting region (LIR) motifs. This process initiates the […]
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  1. Biology

Tumor Microenvironment Effects in Liver Cancer Outcomes

In the realm of cancer research, the understanding of tumor microenvironments continues to evolve, offering deeper insights into how various cellular components interact and influence cancer progression. One of the most intriguing areas of investigation is the role of tertiary lymphoid structures (TLS) and cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC), particularly in cases complicated […]
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  1. Biology

Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis

Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood. Using Caenorhabditiselegans Katanin, which contains the MEI-1 catalytic AAA+ p60 and MEI-2 p80-like regulatory subunits, we identify a critical regulatory role of the N-terminal domain […]
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  1. Biology

Evaluating Pseudomonas and Lactiplantibacillus Against Ralstonia

A recent study has shed light on the comparative biosafety and efficacy of two prominent microbial agents, Pseudomonas fluorescens PFS and Lactiplantibacillus plantarum ZPZ, in their battle against the devastating pathogen Ralstonia solanacearum. This microorganism is notorious for causing wilting diseases in a variety of crops, leading to significant agricultural losses worldwide. Recognizing the urgent […]
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  1. Biology

A new probe illuminates endo-lysosomal Ca 2+ measurements: A role for vesicular IP 3 receptors?

In this issue, Calvo et al. (https://doi.org/10.1083/jcb.202410094) report a new bioluminescent Ca2+ probe (ELGA) targeted to acidic endo-lysosomes (ELs) to permit selective and dynamic recording of endo-lysosomal Ca2+ uptake and release. Ca2+ was not only released by canonical EL channels but, surprisingly, by IP3 receptors.
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  1. Biology

Genetic Insights into Sheep Fur Variations Uncovered

Recent advancements in genomic research have illuminated the complex genetic landscape underlying phenotypic traits in animals. A pivotal study led by Liang et al. has delved into the comparative histomorphometric and transcriptomic analysis of pelage variation in sheep. Their research, soon to be published in the esteemed BMC Genomics journal, provides crucial insights into the […]
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Good Reads

A tiny ocean worm just revealed a big secret about how eyes evolve

A tiny ocean worm just revealed a big secret about how eyes evolve

A research team from the University of Vienna and the Alfred Wegener Institute in Bremerhaven has uncovered how the eyes of adult marine bristleworms continue to increase in size throughout their entire lifespan. The work shows that this constant growth is powered by a ring of neural stem cells that resembles similar structures found in […]
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Will Glacier Melt Lead to Increased Seismic Activity in Mountain Regions? – State of the Planet

A recent study from Earth and Planetary Science Letters is the first to directly link earthquakes to climate change-induced glacial melt. Scientists analyzed 15 years of seismic activity in the Grandes Jorasses—a peak that is part of the Mont Blanc massif between Italy and France—to better understand this association. This massif is one of the […]
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Worlwide

A tiny ocean worm just revealed a big secret about how eyes evolve

A tiny ocean worm just revealed a big secret about how eyes evolve

A research team from the University of Vienna and the Alfred Wegener Institute in Bremerhaven has uncovered how the eyes of adult marine bristleworms continue to increase in size throughout their entire lifespan. The work shows that this constant growth is powered by a ring of neural stem cells that resembles similar structures found in […]
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Will Glacier Melt Lead to Increased Seismic Activity in Mountain Regions? – State of the Planet

A recent study from Earth and Planetary Science Letters is the first to directly link earthquakes to climate change-induced glacial melt. Scientists analyzed 15 years of seismic activity in the Grandes Jorasses—a peak that is part of the Mont Blanc massif between Italy and France—to better understand this association. This massif is one of the […]
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