Biology

  1. Biology

Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments

Intermediate filaments (IFs) are a key component of the cytoskeleton, essential for regulating cell mechanics, maintaining nuclear integrity, organelle positioning, and modulating cell signaling. Current insights into IF function primarily come from studies using long-term perturbations, such as protein depletion or mutation. Here, we present tools that allow rapid manipulation of vimentin IFs in the […]
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  1. Biology

Key Amino Acid Changes Attenuate Yellow Fever Vaccine

In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […]
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  1. Biology

Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division

Lipid synthesis must be precisely regulated to support membrane growth and organelle biogenesis during cell division, yet little is known about how this process is coordinated with other cell cycle events. Here, we show that de novo synthesis of sphingolipids during the S and G2 phases of the cell cycle is essential to increasing nuclear […]
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  1. Biology

Robotic Probe Rapidly Assesses Essential Properties of Novel Materials

In the quest to conquer the limitations of semiconductor materials and their application in solar technologies, a pioneering research team at the Massachusetts Institute of Technology (MIT) has developed an innovative autonomous robotic system. This advancement comes at a crucial time when the demand for efficient energy sources continues to rise. Researchers face significant bottlenecks […]
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  1. Biology

Spindle morphology changes between meiosis and mitosis driven by CK2 regulation of the Ran pathway

The transition from meiotic divisions in the oocyte to embryonic mitoses is a critical step in animal development. Despite negligible changes to cell size and shape, following fertilization the small, barrel-shaped meiotic spindle is replaced by a large zygotic spindle that nucleates abundant astral microtubules at spindle poles. To probe underlying mechanisms, we applied a […]
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  1. Biology

Engineering Breast Cancer Cells for Tumor Vaccines

In the rapidly evolving landscape of cancer immunotherapy, a groundbreaking study has emerged from the laboratories of Martí-Díaz et al., poised to redefine therapeutic strategies for breast cancer. Published in the prestigious journal BMC Cancer, this research delves into the sophisticated engineering of phagocytic signals on breast cancer cells ex vivo, proposing a novel whole […]
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  1. Biology

A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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  1. Biology

Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics

The Cajal body (CB) is a conserved non-membrane nuclear structure where several steps of small nuclear RNP particle (snRNP) biogenesis take place. It has been proposed that CB formation follows a liquid–liquid phase separation model, but this hypothesis has never been rigorously tested. Here, we applied live-cell imaging to show that the key CB assembly […]
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  1. Biology

Dispersion-Engineered Metasurfaces: Debye Relaxation Unveiled

In the rapidly advancing domain of photonics and metamaterials, researchers continually seek novel pathways to manipulate light with precision and efficiency unachievable by conventional means. A groundbreaking study published in Light: Science & Applications by Ahmed, Qi, and Chen heralds a significant leap forward in our understanding and engineering of metasurfaces, focusing on the integration […]
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Good Reads

Key Amino Acid Changes Attenuate Yellow Fever Vaccine

In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […]
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Seeing Glacier Landscapes in a Different Light – State of the Planet

Co-curated by professors of art and science, “Flows of Reflectivity” brings together these distinct disciplines through recent and historic photographs and a time-lapse video of glaciers. The exhibit explores glacier change, with an emphasis on understanding reflectivity—the capacity of ice to send incoming light back into the atmosphere—through an exploration of both the artistic dimension […]
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Worlwide

Key Amino Acid Changes Attenuate Yellow Fever Vaccine

In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […]
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Seeing Glacier Landscapes in a Different Light – State of the Planet

Co-curated by professors of art and science, “Flows of Reflectivity” brings together these distinct disciplines through recent and historic photographs and a time-lapse video of glaciers. The exhibit explores glacier change, with an emphasis on understanding reflectivity—the capacity of ice to send incoming light back into the atmosphere—through an exploration of both the artistic dimension […]
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Create Your Tailored Rubber Stamps Online Using Our Simple Tool for Any Size and Logo – Contact Us Today!

Design Your Rubber Stamps Online with Our Easy-to-Use Tool for Any Size and Logo – Connect with Us Today! Making Your Unique Rubber Stamp on the Web Creating a personalized rubber stamp has never been simpler in the digital era. With the availability of online rubber stamp makers, you can create your own unique designs […]
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