Biology

  1. Biology

Bacteriophage Characterization Paves the Way for Rational Design

In a groundbreaking advancement for virology and structural biology, researchers at the Okinawa Institute of Science and Technology (OIST) and the University of Otago have meticulously elucidated the complete high-resolution structure of the bacteriophage Bas63, a virus known for its specificity in targeting Escherichia coli bacteria. Utilizing state-of-the-art cryogenic electron microscopy (cryo-EM), this study unveils […]
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  1. Biology

Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb

Cell rounding during mitosis necessitates adaptive remodeling of plasma membrane and cortical cytoskeleton. However, the underlying mechanisms remain poorly elucidated. Here, we have identified Numb phosphorylation as a pivotal mechanism in the membrane-cytoskeleton remodeling associated with mitotic cell rounding. Upon mitotic entry, Aurora A phosphorylates Numb, leading to the dissociation of Numb from plasma membrane. […]
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  1. Biology

Unlocking Early-Onset Schizophrenia: Blood Neurotransmitters Revealed

In a groundbreaking study set to ignite discussions within the scientific community, a team of researchers led by Liu et al. has unveiled profound insights into the neurochemical landscape of individuals diagnosed with early-onset schizophrenia. This condition, manifesting before the age of 18, has long puzzled mental health professionals and researchers due to its complex […]
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  1. Biology

Bni5 regulates and coordinates septin architecture and myosin-II functions at the cell division site

The spatiotemporal coordination of septins and myosin-II in processes like cytokinesis is not well understood. In Saccharomyces cerevisiae, Bni5 links the myosin-II heavy chain Myo1 to the septin hourglass at the bud neck prior to cytokinesis, but the underlying mechanisms and functions remain unclear. Here, we show that Bni5 binds septin filaments, the septin-associated kinase […]
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  1. Biology

Boosting Cisplatin Chemo with Niosomal Propolis, Chrysin

In the continuous battle against cancer, one of the cornerstone chemotherapeutic agents, cisplatin, has seen widespread use due to its potent cytotoxic effects against various malignancies. Despite its efficacy, the drug’s clinical utility is often hampered by significant toxicity and the eventual development of resistance by tumor cells. Recently, a groundbreaking study published in Medical […]
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  1. Biology

Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM

The architecture of ER exit sites (ERES), the first sites of membrane remodeling in protein secretion, remains unclear, with descriptions ranging from vesicular clusters to extended tubular structures. We addressed this divergence by visualizing ERES in cells not overexpressing secretory cargo using large-scale volume-focused ion beam scanning EM (FIB-SEM) after high-pressure freeze substitution. Automated segmentation […]
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  1. Biology

Endoscopic Negative Pressure Therapy for Colorectal Leak Salvage

In a groundbreaking study published recently, researchers have unveiled a revolutionary approach to treat post-surgical anastomotic leaks using endoscopic negative pressure therapy. This innovative method stands to change the therapeutic landscape for patients who experience leakage after colorectal resections, a complication that can have dire consequences and traditionally demands more invasive solutions. The study conducted […]
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  1. Biology

Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation

One of the most basic principles in embryonic development is ensuring the proper size of tissues and organs to meet functional needs. So far, an endogenous metabolite regulating organ size has not been described. The current study highlights itaconate, the product of Irg1, in regulating zebrafish neuromast size. Single-cell transcriptomic sequencing analysis of enzymes catalyzing […]
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  1. Biology

Radiomics, AI, Fusion Predict Hidden Lung Cancer

In a groundbreaking study that bridges the cutting edge of medical imaging and artificial intelligence, researchers have unveiled innovative models capable of detecting occult pleural dissemination (PD) in patients with non-small cell lung cancer (NSCLC). This elusive condition, often undetectable on conventional computed tomography (CT) scans, significantly compromises patient prognosis and complicates surgical decision-making. By […]
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  1. Biology

TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification

The acidic pH of lysosomes required for function is established by the electrogenic V-ATPase proton pump. How lysosomes prevent hyper-acidification by the pump is not well established. Recently, the Parkinson’s disease (PD)-associated protein TMEM175 was proposed as a H+-selective channel to leak protons to counter over-acidification. We rigorously address key findings and predictions of this […]
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