Biology

  1. Biology

Slowing down to take it in: Endocytosis during cellular aging

Aging cells functionally decline and accumulate damage through poorly understood mechanisms. In this issue, Antentor et al. (https://doi.org/10.1083/jcb.202412064) find that increased vacuolar pH in older yeast cells slows clathrin-mediated endocytosis. These findings have broad implications in aging-related plasma membrane protein quality control.
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  1. Biology

Nurses Battling Burnout in Ghana

Nurses in Crisis: Unveiling the Depths of Burnout in Ghana’s Haemodialysis Units In the heart of Ghana, a significant crisis is quietly unfolding in healthcare institutions, particularly within the haemodialysis units—an essential service for patients with chronic kidney disease. This service not only demands precision and technical skills but also requires an emotionally resilient workforce. […]
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  1. Biology

Unlocking Wild Apple’s Genomics Through Transcriptome Profiling

In a groundbreaking study published in the journal Discover Plants, researchers have unveiled a comprehensive analysis of the genomic resources of the lesser-known wild apple species, Docynia indica (Wall.) Decne. This research represents a significant milestone in plant genomics, shining a light on the genetic basis of traits that could enhance apple cultivation, disease resistance, […]
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  1. Biology

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Protein trafficking within the endosomal system involves several distinct membrane remodeling events, including those with opposing orientations that lead to the production of intraluminal vesicles (ILVs) and recycling tubules. Components of the endosomal sorting complex required for transport (ESCRT) machinery have been implicated in both pathways, although few studies have directly examined their native dynamics […]
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  1. Biology

Questionnaires for Assessing Patient Preferences in Consultations

In the evolving landscape of healthcare, the significance of patient-provider consultations cannot be overstated. As the paradigm shifts towards a more patient-centered approach, the need for effective communication and understanding between patients and healthcare providers has become increasingly critical. A recent study conducted by a team of researchers, including Bambas, A.Z., Wahidie, D., and Yilmaz-Aslan, […]
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  1. Biology

Can Targeting Inflammation Alleviate Fatigue in Early-Stage Breast Cancer

Emerging research from the University of California, Los Angeles (UCLA) illuminates the complex interplay between inflammation and the multifaceted fatigue experienced by women diagnosed with early-stage breast cancer. Fatigue, a pervasive and often debilitating symptom encountered by cancer patients, encompasses not only physical tiredness but extends into cognitive and emotional exhaustion, thereby profoundly diminishing quality […]
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  1. Biology

Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis

Macrophage phagocytosis is an essential immune response that eliminates pathogens, antibody-opsonized cancer cells, and debris. Macrophages can also trogocytose, or nibble, targets. Trogocytosis and phagocytosis are often activated by the same signal, including IgG antibodies. What makes a macrophage trogocytose instead of phagocytose is not clear. Using both CD47 antibodies and a Her2 chimeric antigen […]
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  1. Biology

WindSTAR Secures NSF Grant to Fuel Advancements in AI Research

The University of Texas at Dallas (UTD) has reinforced its commitment to advancing renewable energy research through the Center for Wind Energy Science, Technology and Research, known as WindSTAR. This esteemed center has recently garnered continued federal funding, signaling the importance and relevance of the research being conducted. Established in collaboration with the University of […]
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  1. Biology

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine (N)-linked protein glycosylation. DLO synthesis can be impaired by genetic and environmental factors, leading to the accumulation of various immature DLO intermediates that are subsequently cleaved into phosphorylated oligosaccharides (POSs). Despite the fact that its activity has been known since the 1970s, the identity of the enzyme […]
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Good Reads

Авиатор от Pin Up: погружаемся в мир отзывов и инсайтов

Что такое Авиатор – простыми словами Авиатор – это онлайн‑игра, где игрок ставит деньги, наблюдает за растущим графиком коэффициента и решает, когда выйти.Чем дольше держишь ставку, тем выше потенциальный выигрыш, но и риск потери возрастает.Механика похожа на рулетку, но с элементом стратегии и интуиции.Интерфейс прост, реакция мгновенная, поэтому даже новичок быстро разберётся. История появления и […]
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Worlwide

Авиатор от Pin Up: погружаемся в мир отзывов и инсайтов

Что такое Авиатор – простыми словами Авиатор – это онлайн‑игра, где игрок ставит деньги, наблюдает за растущим графиком коэффициента и решает, когда выйти.Чем дольше держишь ставку, тем выше потенциальный выигрыш, но и риск потери возрастает.Механика похожа на рулетку, но с элементом стратегии и интуиции.Интерфейс прост, реакция мгновенная, поэтому даже новичок быстро разберётся. История появления и […]
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