Biology Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments Intermediate filaments (IFs) are a key component of the cytoskeleton, essential for regulating cell mechanics, maintaining nuclear integrity, organelle positioning, and modulating cell signaling. Current insights into IF function primarily come from studies using long-term perturbations, such as protein depletion or mutation. Here, we present tools that allow rapid manipulation of vimentin IFs in the […] Written by Admin July 10, 2025July 10, 2025 Saving Bookmark this article Bookmarked
Biology Key Amino Acid Changes Attenuate Yellow Fever Vaccine In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […] Written by Bioengineer July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
Biology Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell division Lipid synthesis must be precisely regulated to support membrane growth and organelle biogenesis during cell division, yet little is known about how this process is coordinated with other cell cycle events. Here, we show that de novo synthesis of sphingolipids during the S and G2 phases of the cell cycle is essential to increasing nuclear […] Written by Admin July 6, 2025July 6, 2025 Saving Bookmark this article Bookmarked
Biology Robotic Probe Rapidly Assesses Essential Properties of Novel Materials In the quest to conquer the limitations of semiconductor materials and their application in solar technologies, a pioneering research team at the Massachusetts Institute of Technology (MIT) has developed an innovative autonomous robotic system. This advancement comes at a crucial time when the demand for efficient energy sources continues to rise. Researchers face significant bottlenecks […] Written by Bioengineer July 5, 2025July 5, 2025 Saving Bookmark this article Bookmarked
Biology Spindle morphology changes between meiosis and mitosis driven by CK2 regulation of the Ran pathway The transition from meiotic divisions in the oocyte to embryonic mitoses is a critical step in animal development. Despite negligible changes to cell size and shape, following fertilization the small, barrel-shaped meiotic spindle is replaced by a large zygotic spindle that nucleates abundant astral microtubules at spindle poles. To probe underlying mechanisms, we applied a […] Written by Admin July 3, 2025July 3, 2025 Saving Bookmark this article Bookmarked
Biology Engineering Breast Cancer Cells for Tumor Vaccines In the rapidly evolving landscape of cancer immunotherapy, a groundbreaking study has emerged from the laboratories of Martí-Díaz et al., poised to redefine therapeutic strategies for breast cancer. Published in the prestigious journal BMC Cancer, this research delves into the sophisticated engineering of phagocytic signals on breast cancer cells ex vivo, proposing a novel whole […] Written by Bioengineer July 1, 2025July 1, 2025 Saving Bookmark this article Bookmarked
Biology A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […] Written by Admin June 29, 2025June 29, 2025 Saving Bookmark this article Bookmarked
Biology Consortium Seeks to Launch Major Carbon Removal Initiatives Experts in the field of carbon capture and climate solutions are coming together for a pivotal meeting in Exeter, aimed at spearheading the development of a new carbon economy. The New Carbon Economy Consortium (NCEC), a key player in the global effort to manage carbon emissions, will host its annual meeting at the University of […] Written by Bioengineer June 27, 2025June 27, 2025 Saving Bookmark this article Bookmarked
Biology Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics The Cajal body (CB) is a conserved non-membrane nuclear structure where several steps of small nuclear RNP particle (snRNP) biogenesis take place. It has been proposed that CB formation follows a liquid–liquid phase separation model, but this hypothesis has never been rigorously tested. Here, we applied live-cell imaging to show that the key CB assembly […] Written by Admin June 26, 2025June 26, 2025 Saving Bookmark this article Bookmarked
Biology Dispersion-Engineered Metasurfaces: Debye Relaxation Unveiled In the rapidly advancing domain of photonics and metamaterials, researchers continually seek novel pathways to manipulate light with precision and efficiency unachievable by conventional means. A groundbreaking study published in Light: Science & Applications by Ahmed, Qi, and Chen heralds a significant leap forward in our understanding and engineering of metasurfaces, focusing on the integration […] Written by Bioengineer June 24, 2025June 24, 2025 Saving Bookmark this article Bookmarked
Key Amino Acid Changes Attenuate Yellow Fever Vaccine In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […] Written by Bioengineer July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
Seeing Glacier Landscapes in a Different Light – State of the Planet Co-curated by professors of art and science, “Flows of Reflectivity” brings together these distinct disciplines through recent and historic photographs and a time-lapse video of glaciers. The exhibit explores glacier change, with an emphasis on understanding reflectivity—the capacity of ice to send incoming light back into the atmosphere—through an exploration of both the artistic dimension […] Written by Guest July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
Key Amino Acid Changes Attenuate Yellow Fever Vaccine In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […] Written by Bioengineer July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
Seeing Glacier Landscapes in a Different Light – State of the Planet Co-curated by professors of art and science, “Flows of Reflectivity” brings together these distinct disciplines through recent and historic photographs and a time-lapse video of glaciers. The exhibit explores glacier change, with an emphasis on understanding reflectivity—the capacity of ice to send incoming light back into the atmosphere—through an exploration of both the artistic dimension […] Written by Guest July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
Create Your Tailored Rubber Stamps Online Using Our Simple Tool for Any Size and Logo – Contact Us Today! Design Your Rubber Stamps Online with Our Easy-to-Use Tool for Any Size and Logo – Connect with Us Today! Making Your Unique Rubber Stamp on the Web Creating a personalized rubber stamp has never been simpler in the digital era. With the availability of online rubber stamp makers, you can create your own unique designs […] Written by maziemccasland1 July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked