Biology

  1. Biology

New Arabidopsis BIK1 Alleles Confirm Immunity Role

In a groundbreaking study poised to redefine our understanding of plant immunity, researchers have unveiled novel insights into the pivotal roles of the receptor-like cytoplasmic kinases BIK1 and PBL1 in Arabidopsis. These kinases, previously studied primarily through single transfer DNA (T-DNA) insertional mutant alleles, are reaffirmed as central players in the plant’s pattern-triggered immunity (PTI) […]
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The traffic controller: GARLH4 dictates neuroligin synapse-type preference

Neuroligin isoforms are commonly thought to intrinsically specify synapse identity. In this issue, Yamasaki et al. (https://doi.org/10.1083/jcb.202507190) show that the auxiliary protein GARLH4 (LHFPL4) instead dictates neuroligin preference via competitive hierarchy, enabling dynamic reassignment between excitatory and inhibitory postsynaptic domains.
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  1. Biology

Eco-Friendly CoAl2O4@ZnO Nanocomposite for Tetracycline Degradation

In a groundbreaking study published in Scientific Reports, a team of researchers from various institutions has unveiled a novel approach to synthesizing cobalt aluminate (CoAl₂O₄) coupled with zinc oxide (ZnO) nanocomposites. This research, spearheaded by Nejadkhorasani, Zali Boeini, and Taghavi Fardood, explores the green synthesis of these nanocomposites using the natural gum of Amygdalus scoparia […]
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Endoplasmic reticulum patterns insect cuticle nanostructure

Insect cuticles with nano-level structures exhibit functional surface properties such as the photonic nanocrystal of the butterfly wing scale with structural color and the corneal nipple arrays of superhydrophobic compound eye lens. Despite the enormous influence the cuticle has had on biomimetic industrial applications, cellular mechanisms of cuticular nanopatterning remain poorly understood. Drosophila gore-tex/Osiris23 (gox) […]
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Exploring HXSJ Decoction’s Role in Ferroptosis and Venous Leg Ulcers

In an increasingly interconnected realm of medicine and traditional therapies, the emergence of HXSJ decoction as a potential remedy for venous leg ulcers has raised significant interest among researchers and clinicians alike. Venous leg ulcers represent a painful and debilitating condition caused by poor venous circulation. These chronic wounds not only affect patients’ quality of […]
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Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments

Lipid bilayers form the basis of organellar architecture, structure, and compartmentalization in the cell. Decades of biophysical, biochemical, and imaging studies on purified or in vitro–reconstituted liposomes have shown that variations in lipid composition influence the physical properties of membranes, such as thickness and curvature. However, similar studies characterizing these membrane properties within the native […]
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Chloroplast Genome of Ecklonia maxima: A Comparative Study

In a groundbreaking study published in the esteemed BMC Genomics, researchers have unveiled the complete chloroplast genome of Ecklonia maxima, a brown algae species celebrated for its ecological and economic significance along the coastlines of Southern Africa. The implications of this comprehensive analysis extend far beyond mere genetic sequencing; they pave the way for a […]
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  1. Biology

New Phase 2 Trial Boosts Stage III NSCLC Treatment

In a groundbreaking effort to enhance the treatment landscape of stage III non-small cell lung cancer (NSCLC), researchers have recently reported compelling results from the phase 2 APOLO trial, which combines induction chemo-immunotherapy with subsequent chemo-radiotherapy and immunotherapy maintenance. This innovative therapeutic approach aims to maximize tumor control by strategically integrating multiple modalities that harness […]
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  1. Biology

Keeping a stiff upper lip: p120ctn and tissue fusion

In this issue, Teng et al. (https://doi.org/10.1083/jcb.202503070) use genome editing, classical tissue-specific gene knockouts, and live cell imaging to show that the interaction of p120ctn with the juxtamembrane domain of classical cadherins is necessary for tissue integrity during the cellular zippering required for upper lip formation in mammals.
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The traffic controller: GARLH4 dictates neuroligin synapse-type preference

Neuroligin isoforms are commonly thought to intrinsically specify synapse identity. In this issue, Yamasaki et al. (https://doi.org/10.1083/jcb.202507190) show that the auxiliary protein GARLH4 (LHFPL4) instead dictates neuroligin preference via competitive hierarchy, enabling dynamic reassignment between excitatory and inhibitory postsynaptic domains.
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The traffic controller: GARLH4 dictates neuroligin synapse-type preference

Neuroligin isoforms are commonly thought to intrinsically specify synapse identity. In this issue, Yamasaki et al. (https://doi.org/10.1083/jcb.202507190) show that the auxiliary protein GARLH4 (LHFPL4) instead dictates neuroligin preference via competitive hierarchy, enabling dynamic reassignment between excitatory and inhibitory postsynaptic domains.
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