Biology

  1. Biology

Dental Stem Cells Differentiate on Biodentine Nanofibers

In a groundbreaking advance within the field of regenerative medicine, researchers have unveiled a novel approach to enhance dental and bone tissue engineering by leveraging the unique properties of dental pulp stem cells (DPSCs) cultured on specially designed polymer nanofibers. The study, recently published in BioMedical Engineering OnLine, explores the odontogenic and osteogenic potential of […]
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  1. Biology

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Membrane contact sites (MCSs) establish organelle interactomes in cells to enable communication and exchange of materials. Volume EM (vEM) is ideally suited for MCS analyses, but semantic segmentation of large vEM datasets remains challenging. Recent adoption of artificial intelligence (AI) for segmentation has greatly enhanced our analysis capabilities. However, we show that organelle boundaries, which […]
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  1. Biology

Merbecovirus S2 Vaccines Trigger Cross-Reactive MERS Protection

In a groundbreaking study recently published in npj Viruses, a team of researchers led by Halfmann and colleagues has unveiled promising new insights into vaccine design against Merbecoviruses, a subgenus of coronaviruses that includes the Middle East Respiratory Syndrome coronavirus (MERS-CoV). Their work focuses on the S2 subunit of the spike (S) glycoprotein, a component […]
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  1. Biology

Tubulin isotypes contribute opposing properties to balance anaphase spindle morphogenesis

Faithful chromosome segregation requires proper function of the mitotic spindle, which is built from, and depends on, the coordinated regulation of many microtubules and the activities of molecular motors and MAPs. In addition, microtubules themselves are assembled from multiple variants, or isotypes of α- and β-tubulin, yet whether they mediate the activities of motors and […]
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  1. Biology

Ancient Texts Decoded by Neural Networks

In a groundbreaking fusion of ancient history and cutting-edge artificial intelligence, researchers have unveiled Aeneas, a sophisticated machine learning model designed to revolutionize the study of Latin inscriptions. This technological marvel aims to assist historians by restoring fragmented texts, dating undocumented carvings, and pinpointing their geographic origins within the vast expanse of the Roman Empire. […]
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  1. Biology

The Unkempt RNA-binding protein reveals a local translation program in centriole overduplication

Excess centrosomes cause defects in mitosis, cell-signaling, and cell migration, and therefore their assembly is tightly regulated. The divergent Polo kinase, PLK4, controls centriole duplication at the heart of centrosome assembly, and elevated PLK4 levels promote centrosome amplification (CA), a founding event of tumorigenesis. Here, we investigate the transcriptional consequences of elevated PLK4 and find […]
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  1. Biology

Additive Manufacturing of Monolithic Gyroidal Solid Oxide Cells

In a transformative leap that challenges longstanding constraints in energy conversion technology, researchers have unveiled a groundbreaking design paradigm for solid oxide cells (SOCs) that dramatically enhances their efficiency, durability, and structural integration. Traditional SOCs, fundamental devices capable of interconverting chemical energy and electricity at high temperatures, have been largely limited by planar, two-dimensional (2D) […]
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  1. Biology

Archaeal Ribosome Shows Unique Active Site, Hibernation Factor

In the intricate machinery of life, ribosomes stand as the quintessential molecular factories responsible for translating genetic information into functional proteins. These macromolecular complexes orchestrate the decoding of messenger RNA (mRNA) into polypeptide chains, a process fundamental to all cellular organisms. Despite the long evolutionary journey and the structural variations observed across different domains of […]
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  1. Biology

A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells

HaloTag technology represents a versatile tool for studying proteins. Fluorescent HaloTag ligands employed in sequential labeling led to the discovery of distinct protein variants for histones, cohesins, and MCM complexes. However, an efficient biochemical approach to separate these distinct protein variants to study their biological functions is missing. Principally, being a gap in technology, the […]
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Good Reads

Can Mayor Mamdani Turn Climate Action Into an Affordability Win for NYC?  – State of the Planet

Below-average temperatures and gusty winds did not deter tens of thousands of people from gathering in lower Manhattan last week to witness Zohran Mamdani take an oath to become New York City’s next mayor.  Mayor Zohran Mamdani. Credit: Karamccurdy via Wikimedia Commons “Beginning today, we will govern expansively and audaciously,” Mamdani said during his inauguration speech. “We may not always succeed, but never will we be accused of lacking […]
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The biggest biotech funding rounds in November 2025

The biggest biotech funding rounds in December 2025

The companies Kymera Therapeutics, Immunovant, and Dyne Therapeutics bagged the biggest biotech funding rounds overall in December 2025 across private and public funding types. In this article, we break down last month’s private and public fundraising activity, looking at the largest rounds in more detail. Private biotech funding rounds in December 2025 First, let’s take […]
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Worlwide

Can Mayor Mamdani Turn Climate Action Into an Affordability Win for NYC?  – State of the Planet

Below-average temperatures and gusty winds did not deter tens of thousands of people from gathering in lower Manhattan last week to witness Zohran Mamdani take an oath to become New York City’s next mayor.  Mayor Zohran Mamdani. Credit: Karamccurdy via Wikimedia Commons “Beginning today, we will govern expansively and audaciously,” Mamdani said during his inauguration speech. “We may not always succeed, but never will we be accused of lacking […]
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The biggest biotech funding rounds in November 2025

The biggest biotech funding rounds in December 2025

The companies Kymera Therapeutics, Immunovant, and Dyne Therapeutics bagged the biggest biotech funding rounds overall in December 2025 across private and public funding types. In this article, we break down last month’s private and public fundraising activity, looking at the largest rounds in more detail. Private biotech funding rounds in December 2025 First, let’s take […]
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