Biology

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Dr. Romina Mizrahi Explores the Role of

In a significant advancement in the field of psychiatric research, Dr. Romina Mizrahi, a prominent figure at McGill University and the Douglas Research Center in Canada, is advocating for the integration of molecular-level analyses in understanding mental health disorders. Her work emphasizes the vital role of positron emission tomography (PET) in psychiatric medicine, aiming to […]
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  1. Biology

The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling

Precise output from the conserved Notch signaling pathway governs a plethora of cellular processes and developmental transitions. Unlike other pathways that use a cytoplasmic relay, the Notch cell surface receptor transduces signaling directly to the nucleus, with endocytic trafficking providing critical regulatory nodes. Here we report that the cytoplasmic tyrosine kinase Abelson (Abl) facilitates Notch […]
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  1. Biology

Exploring Who Bears the Cost of Portal Messaging Among Older Adults and

In the rapidly evolving landscape of healthcare technology, the ability for older adults to communicate with their healthcare providers through digital means has transformed how medical interactions occur. Historically, this demographic relied heavily on phone calls to communicate health concerns, with even simple inquiries often necessitating an in-person visit. As the healthcare field shifts towards […]
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  1. Biology

Long-Term Health Benefits of Medicinal Cannabis Linked to Improved Quality

Improvements in health-related quality of life (HRQL) have been maintained long-term in patients prescribed medicinal cannabis, according to a groundbreaking observational study conducted in Australia. The research, published on April 2, 2025, in the esteemed journal PLOS One, is a significant addition to the growing body of evidence supporting medicinal cannabis as a viable treatment […]
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  1. Biology

Automated Health Record Analysis Reveals Undiagnosed Hypertension in

A transformative study conducted by a team from Mass General Brigham has unearthed significant insights into the realm of hypertension—often dubbed the “silent killer.” This investigation leverages the vast troves of information encoded within electronic health records (EHR) and employs advanced natural language processing (NLP) techniques to draw attention to subtle indicators of hypertension in […]
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  1. Biology

Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in Tetrahymena

We explored how the number of structures is determined in an intracellular organelle series. In Tetrahymena, the oral apparatus contains three diagonal ciliary rows: M1, M2, and M3. During development, the M rows emerge by sequential segmentation of a group of basal bodies, starting with the longest and most anterior M1 and ending with the […]
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  1. Biology

Novel Strategy Offers Hope for Treating Anthrax After the ‘Point of No

In recent research that unveils novel strategies for combating anthrax, University of Pittsburgh scientists have demonstrated a groundbreaking approach to treating the life-threatening disease. Known primarily as an infection induced by the bacterium Bacillus anthracis, anthrax poses significant dangers, particularly due to its potential as a bioweapon. While the disease can often be effectively managed […]
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  1. Biology

Intersection of GPCR trafficking and cAMP signaling at endomembranes

GPCRs comprise the largest family of signaling receptors and control essentially every physiological process. Many biochemical reactions underlying GPCR signaling are now elucidated to atomic resolution in cell-free preparations, but how elemental signaling reactions are organized in intact cells remains less clear. Significant progress has been made toward bridging this knowledge gap by leveraging new […]
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  1. Biology

Innovative Tool Enhances the Efficacy of Cancer Immunotherapy

On the forefront of cancer research, a groundbreaking study has emerged, shedding light on how to enhance the efficacy of Natural Killer (NK) cells against malignant tumors. These specialized lymphocytes play an essential role in the immune system, armed with the ability to detect and obliterate cancer cells. Despite their formidable capabilities, NK cells often […]
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