Biology

  1. Biology

Detailing organelle division and segregation in Plasmodium falciparum

The malaria-causing parasite, P. falciparum, replicates through schizogony, a tightly orchestrated process where numerous daughter parasites are formed simultaneously. Proper division and segregation of one-per-cell organelles, like the mitochondrion and apicoplast, are essential, yet remain poorly understood. We developed a new reporter parasite line that allows visualization of the mitochondrion in blood and mosquito stages. […]
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  1. Biology

Kinetochores grip microtubules with directionally asymmetric strength

For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […]
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  1. Biology

Postsynaptic BMP signaling regulates myonuclear properties in Drosophila larval muscles

The syncytial mammalian muscle fiber contains a heterogeneous population of (myo)nuclei. At the neuromuscular junction (NMJ), myonuclei have specialized positioning and gene expression. However, it remains unclear how myonuclei are recruited and what regulates myonuclear output at the NMJ. Here, we identify specific properties of myonuclei located near the Drosophila larval NMJ. These synaptic myonuclei […]
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  1. Biology

Racing through C. elegans mitosis using cyclin B3

Racecar drivers use left-foot braking, i.e., simultaneously engaging brake and throttle, to carefully balance acceleration and traction when navigating chicanes. In this issue, Lara-Gonzalez et al. (https://doi.org/10.1083/jcb.202308034) show that C. elegans embryos employ the molecular equivalent of left-foot braking to faithfully speed through mitosis.
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  1. Biology

CYRI controls epidermal wound closure and cohesion of invasive border cell cluster in Drosophila

Cell motility is crucial for many biological processes including morphogenesis, wound healing, and cancer invasion. The WAVE regulatory complex (WRC) is a central Arp2/3 regulator driving cell motility downstream of activation by Rac GTPase. CYFIP-related Rac1 interactor (CYRI) proteins are thought to compete with WRC for interaction with Rac1 in a feedback loop regulating lamellipodia […]
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  1. Biology

PFAS influence the development and function of the brain

Because of their special properties – heat resistance, water and grease repellence, and high durability – PFAS are used in many everyday products (e.g. cosmetics, outdoor clothing, and coated cookware). But it is precisely these properties that make them so problematic. “Because some PFAS are chemically stable, they accumulate in the environment and enter our […]
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  1. Biology

At-risk butterflies more likely to survive with human help

VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a […]
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  1. Biology

City of Hope to offer second opinions for cancer patients in Southeast Asia

LOS ANGELES — Oncology specialists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, can now provide leading-edge clinical guidance to patients living in Southeast Asia through a second opinion collaboration agreement with the Healthway Cancer Care Hospital, the first comprehensive cancer hospital in […]
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Good Reads

Robotic Probe Rapidly Assesses Essential Properties of Novel Materials

In the quest to conquer the limitations of semiconductor materials and their application in solar technologies, a pioneering research team at the Massachusetts Institute of Technology (MIT) has developed an innovative autonomous robotic system. This advancement comes at a crucial time when the demand for efficient energy sources continues to rise. Researchers face significant bottlenecks […]
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Robotic Probe Rapidly Assesses Essential Properties of Novel Materials

In the quest to conquer the limitations of semiconductor materials and their application in solar technologies, a pioneering research team at the Massachusetts Institute of Technology (MIT) has developed an innovative autonomous robotic system. This advancement comes at a crucial time when the demand for efficient energy sources continues to rise. Researchers face significant bottlenecks […]
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600-million-year-old body blueprint found in sea anemones

600-million-year-old body blueprint found in sea anemones

A new study from the University of Vienna reveals that sea anemones use a molecular mechanism known from bilaterian animals to form their back-to-belly body axis. This mechanism (“BMP shuttling”) enables cells to organize themselves during development by interpreting signaling gradients. The findings, published in Science Advances, suggest that this system evolved much earlier than […]
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