Biology

  1. Biology

TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification

The acidic pH of lysosomes required for function is established by the electrogenic V-ATPase proton pump. How lysosomes prevent hyper-acidification by the pump is not well established. Recently, the Parkinson’s disease (PD)-associated protein TMEM175 was proposed as a H+-selective channel to leak protons to counter over-acidification. We rigorously address key findings and predictions of this […]
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  1. Biology

IQ Estimates in Fragile X: Abbreviated vs. Full-Scale

Recent advancements in psychological assessment methodologies have sparked renewed interest in understanding cognitive functioning in individuals with Fragile X Syndrome (FXS). The original study by McKinney et al. delves into a critical investigation of the discrepancies between abbreviated and full-scale IQ assessments as per the Stanford-Binet test, revealing nuanced variations across developmental stages. Such insights […]
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  1. Biology

Fibroblasts promote osmotic surveillance by wound-induced unique calcium patterns

Fibroblasts are pivotal in tissue homeostasis, contributing to tissue repair and environmental sensing. Studying their role in zebrafish has been hampered by the lack of robust transgene expression tools. Here, we developed a fin fibroblast-specific synthetic promoter by combining the zebrafish itga11a regulatory region with the murine cFos minimal promoter. Establishing this itga11a-cFos promoter in […]
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  1. Biology

Anticancer Effects in Mesothelioma Cells

In a groundbreaking study published in BMC Cancer, researchers have unveiled the potent anticancer properties of cephalomannine, a compound showing remarkable efficacy against pleural mesothelioma (PM), a notoriously aggressive and treatment-resistant form of cancer. This research not only highlights the therapeutic potential of cephalomannine but also elucidates the cellular mechanisms underpinning its anticancer activity, offering […]
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  1. Biology

A key role of Canoe’s intrinsically disordered region in linking cell junctions to the cytoskeleton

Adherens junctions regulate tissue architecture, mediating robust yet dynamic cell–cell adhesion and, via cytoskeletal linkage, allowing cells to change shape and move. Adherens junctions contain thousands of molecules linked by multivalent interactions of folded protein domains and intrinsically disordered regions (IDRs). One key challenge is defining mechanisms conferring robust linkage and mechanosensing. Drosophila Canoe and […]
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  1. Biology

Boosting Nursing Informatics Literacy with Design Learning

In the rapidly evolving field of healthcare, the convergence of nursing and informatics has become increasingly critical. New research conducted by a team of scholars, led by Ming Shen, alongside colleagues Zhiwei Feng and Ying Shen, has illuminated a transformative approach to enhancing informatics literacy among undergraduate nursing students. The study, titled “Enhancing undergraduate nursing […]
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  1. Biology

Slowing down to take it in: Endocytosis during cellular aging

Aging cells functionally decline and accumulate damage through poorly understood mechanisms. In this issue, Antentor et al. (https://doi.org/10.1083/jcb.202412064) find that increased vacuolar pH in older yeast cells slows clathrin-mediated endocytosis. These findings have broad implications in aging-related plasma membrane protein quality control.
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  1. Biology

Nurses Battling Burnout in Ghana

Nurses in Crisis: Unveiling the Depths of Burnout in Ghana’s Haemodialysis Units In the heart of Ghana, a significant crisis is quietly unfolding in healthcare institutions, particularly within the haemodialysis units—an essential service for patients with chronic kidney disease. This service not only demands precision and technical skills but also requires an emotionally resilient workforce. […]
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  1. Biology

Unlocking Wild Apple’s Genomics Through Transcriptome Profiling

In a groundbreaking study published in the journal Discover Plants, researchers have unveiled a comprehensive analysis of the genomic resources of the lesser-known wild apple species, Docynia indica (Wall.) Decne. This research represents a significant milestone in plant genomics, shining a light on the genetic basis of traits that could enhance apple cultivation, disease resistance, […]
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Good Reads

A tiny ocean worm just revealed a big secret about how eyes evolve

A tiny ocean worm just revealed a big secret about how eyes evolve

A research team from the University of Vienna and the Alfred Wegener Institute in Bremerhaven has uncovered how the eyes of adult marine bristleworms continue to increase in size throughout their entire lifespan. The work shows that this constant growth is powered by a ring of neural stem cells that resembles similar structures found in […]
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Will Glacier Melt Lead to Increased Seismic Activity in Mountain Regions? – State of the Planet

A recent study from Earth and Planetary Science Letters is the first to directly link earthquakes to climate change-induced glacial melt. Scientists analyzed 15 years of seismic activity in the Grandes Jorasses—a peak that is part of the Mont Blanc massif between Italy and France—to better understand this association. This massif is one of the […]
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Worlwide

A tiny ocean worm just revealed a big secret about how eyes evolve

A tiny ocean worm just revealed a big secret about how eyes evolve

A research team from the University of Vienna and the Alfred Wegener Institute in Bremerhaven has uncovered how the eyes of adult marine bristleworms continue to increase in size throughout their entire lifespan. The work shows that this constant growth is powered by a ring of neural stem cells that resembles similar structures found in […]
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Will Glacier Melt Lead to Increased Seismic Activity in Mountain Regions? – State of the Planet

A recent study from Earth and Planetary Science Letters is the first to directly link earthquakes to climate change-induced glacial melt. Scientists analyzed 15 years of seismic activity in the Grandes Jorasses—a peak that is part of the Mont Blanc massif between Italy and France—to better understand this association. This massif is one of the […]
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