Biology

  1. Biology

Activation of lysosomal Ca 2+ channels mitigates mitochondrial damage and oxidative stress

Elevated levels of plasma-free fatty acids and oxidative stress have been identified as putative primary pathogenic factors in endothelial dysfunction etiology, though their roles are unclear. In human endothelial cells, we found that saturated fatty acids (SFAs)—including the plasma-predominant palmitic acid (PA)—cause mitochondrial fragmentation and elevation of intracellular reactive oxygen species (ROS) levels. TRPML1 is […]
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  1. Biology

Detailing organelle division and segregation in Plasmodium falciparum

The malaria-causing parasite, P. falciparum, replicates through schizogony, a tightly orchestrated process where numerous daughter parasites are formed simultaneously. Proper division and segregation of one-per-cell organelles, like the mitochondrion and apicoplast, are essential, yet remain poorly understood. We developed a new reporter parasite line that allows visualization of the mitochondrion in blood and mosquito stages. […]
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  1. Biology

Kinetochores grip microtubules with directionally asymmetric strength

For accurate mitosis, all chromosomes must achieve “biorientation,” with replicated sister chromatids coupled via kinetochores to the plus ends of opposing microtubules. However, kinetochores first bind the sides of microtubules and subsequently find plus ends through a trial-and-error process; accurate biorientation depends on the selective release of erroneous attachments. Proposed mechanisms for error-correction have focused […]
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  1. Biology

Postsynaptic BMP signaling regulates myonuclear properties in Drosophila larval muscles

The syncytial mammalian muscle fiber contains a heterogeneous population of (myo)nuclei. At the neuromuscular junction (NMJ), myonuclei have specialized positioning and gene expression. However, it remains unclear how myonuclei are recruited and what regulates myonuclear output at the NMJ. Here, we identify specific properties of myonuclei located near the Drosophila larval NMJ. These synaptic myonuclei […]
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  1. Biology

Racing through C. elegans mitosis using cyclin B3

Racecar drivers use left-foot braking, i.e., simultaneously engaging brake and throttle, to carefully balance acceleration and traction when navigating chicanes. In this issue, Lara-Gonzalez et al. (https://doi.org/10.1083/jcb.202308034) show that C. elegans embryos employ the molecular equivalent of left-foot braking to faithfully speed through mitosis.
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  1. Biology

CYRI controls epidermal wound closure and cohesion of invasive border cell cluster in Drosophila

Cell motility is crucial for many biological processes including morphogenesis, wound healing, and cancer invasion. The WAVE regulatory complex (WRC) is a central Arp2/3 regulator driving cell motility downstream of activation by Rac GTPase. CYFIP-related Rac1 interactor (CYRI) proteins are thought to compete with WRC for interaction with Rac1 in a feedback loop regulating lamellipodia […]
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  1. Biology

PFAS influence the development and function of the brain

Because of their special properties – heat resistance, water and grease repellence, and high durability – PFAS are used in many everyday products (e.g. cosmetics, outdoor clothing, and coated cookware). But it is precisely these properties that make them so problematic. “Because some PFAS are chemically stable, they accumulate in the environment and enter our […]
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  1. Biology

At-risk butterflies more likely to survive with human help

VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a […]
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  1. Biology

City of Hope to offer second opinions for cancer patients in Southeast Asia

LOS ANGELES — Oncology specialists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, can now provide leading-edge clinical guidance to patients living in Southeast Asia through a second opinion collaboration agreement with the Healthway Cancer Care Hospital, the first comprehensive cancer hospital in […]
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Good Reads

A proteome-wide yeast degron collection for the dynamic study of protein function

Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out. Specifically, libraries that involve a cellular perturbation, such as the deletion collection, have facilitated key biological discoveries. However, short-term rewiring and long-term accumulation of suppressor mutations often obscure the functional consequences of such perturbations. We present the AID library […]
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Columbia Climate School Hosts Ninth Annual Sustainability Careers Reception – State of the Planet

Practitioners who attended the 2024 Sustainability Careers Reception. (*See below for names and affiliations) Last month, the Columbia Climate School hosted its ninth annual Sustainability Careers Reception at the Columbia Club in Midtown Manhattan. Thirty-three sustainability professionals and 88 Columbia students from varying backgrounds and degree pursuits gathered to discuss the ever-pressing challenges and real-world […]
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A proteome-wide yeast degron collection for the dynamic study of protein function

Genome-wide collections of yeast strains, known as libraries, revolutionized the way systematic studies are carried out. Specifically, libraries that involve a cellular perturbation, such as the deletion collection, have facilitated key biological discoveries. However, short-term rewiring and long-term accumulation of suppressor mutations often obscure the functional consequences of such perturbations. We present the AID library […]
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Columbia Climate School Hosts Ninth Annual Sustainability Careers Reception – State of the Planet

Practitioners who attended the 2024 Sustainability Careers Reception. (*See below for names and affiliations) Last month, the Columbia Climate School hosted its ninth annual Sustainability Careers Reception at the Columbia Club in Midtown Manhattan. Thirty-three sustainability professionals and 88 Columbia students from varying backgrounds and degree pursuits gathered to discuss the ever-pressing challenges and real-world […]
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Scientists uncover new way viruses fight back against bacteria

Conserving high-elevation grasslands in Peru is key to protect Andean bears

Andean bears carefully select the best foraging locations and plants to maximize nutrition and avoid livestock, according to a study publishing December 18, 2024, in the open-access journal PLOS ONE by Nicholas Pilfold at the San Diego Zoo Wildlife Alliance in California, U.S., and colleagues. Andean bears, also known as ‘spectacled bears’ because of the […]
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