Biology The Unkempt RNA-binding protein reveals a local translation program in centriole overduplication Excess centrosomes cause defects in mitosis, cell-signaling, and cell migration, and therefore their assembly is tightly regulated. The divergent Polo kinase, PLK4, controls centriole duplication at the heart of centrosome assembly, and elevated PLK4 levels promote centrosome amplification (CA), a founding event of tumorigenesis. Here, we investigate the transcriptional consequences of elevated PLK4 and find […] Written by Admin July 24, 2025July 24, 2025 Saving Bookmark this article Bookmarked
Biology Additive Manufacturing of Monolithic Gyroidal Solid Oxide Cells In a transformative leap that challenges longstanding constraints in energy conversion technology, researchers have unveiled a groundbreaking design paradigm for solid oxide cells (SOCs) that dramatically enhances their efficiency, durability, and structural integration. Traditional SOCs, fundamental devices capable of interconverting chemical energy and electricity at high temperatures, have been largely limited by planar, two-dimensional (2D) […] Written by Bioengineer July 23, 2025July 23, 2025 Saving Bookmark this article Bookmarked
Biology Driven to cannibalism: A hormonal trigger for phagocytosis In this issue, Ghosh et al. (https://doi.org/10.1083/jcb.202411073) reveal that a hormonal cue induces ovarian stretch follicle cells to cannibalize adjacent nurse cells—a process necessary to remodel egg chambers into viable eggs. Written by Admin July 21, 2025July 21, 2025 Saving Bookmark this article Bookmarked
Biology Archaeal Ribosome Shows Unique Active Site, Hibernation Factor In the intricate machinery of life, ribosomes stand as the quintessential molecular factories responsible for translating genetic information into functional proteins. These macromolecular complexes orchestrate the decoding of messenger RNA (mRNA) into polypeptide chains, a process fundamental to all cellular organisms. Despite the long evolutionary journey and the structural variations observed across different domains of […] Written by Bioengineer July 19, 2025July 19, 2025 Saving Bookmark this article Bookmarked
Biology A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells HaloTag technology represents a versatile tool for studying proteins. Fluorescent HaloTag ligands employed in sequential labeling led to the discovery of distinct protein variants for histones, cohesins, and MCM complexes. However, an efficient biochemical approach to separate these distinct protein variants to study their biological functions is missing. Principally, being a gap in technology, the […] Written by Admin July 17, 2025July 17, 2025 Saving Bookmark this article Bookmarked
Biology Flowering Plant Gene Regulation: Recruitment, Rewiring, Conservation In the sprawling and intricately wired world of plant genetics, transcription factors (TFs) have emerged as central conductors orchestrating gene expression. These proteins bind to discrete regions of DNA, known as transcription factor binding sites (TFBSs), modulating when and where genes become active. This process underpins every aspect of plant life, from cellular identity and […] Written by Bioengineer July 15, 2025July 15, 2025 Saving Bookmark this article Bookmarked
Biology Nonmuscle myosin II regulates presynaptic actin and neuronal mechanobiology in Drosophila Neuromuscular junctions (NMJs) are evolutionarily ancient, specialized contacts between neurons and muscles. They experience lifelong strain, yet the mechanism preserving their integrity under mechanical load remains unclear. Here, we identify a novel actomyosin structure at Drosophila larval NMJs, consisting of a long-lived, low-turnover presynaptic actin core that colocalizes with nonmuscle myosin II (NMII) and becomes […] Written by Admin July 14, 2025July 14, 2025 Saving Bookmark this article Bookmarked
Biology Metabolic Syndrome Links BMI and Depression Trajectories In a groundbreaking cohort study emerging from China, researchers have explored the complex interplay between body mass index (BMI), depressive symptoms, and metabolic syndrome in adults over the age of 45. This investigation not only illuminates the intricate cross-sectional and longitudinal associations between these health parameters but also delves into the mediating influence of metabolic […] Written by Bioengineer July 12, 2025July 12, 2025 Saving Bookmark this article Bookmarked
Biology Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments Intermediate filaments (IFs) are a key component of the cytoskeleton, essential for regulating cell mechanics, maintaining nuclear integrity, organelle positioning, and modulating cell signaling. Current insights into IF function primarily come from studies using long-term perturbations, such as protein depletion or mutation. Here, we present tools that allow rapid manipulation of vimentin IFs in the […] Written by Admin July 10, 2025July 10, 2025 Saving Bookmark this article Bookmarked
Biology Key Amino Acid Changes Attenuate Yellow Fever Vaccine In a groundbreaking study published in Nature Microbiology, researchers have uncovered the molecular underpinnings that enable the yellow fever 17D vaccine strain to be both highly effective and unusually safe. Through meticulous molecular analyses, Zhang, Chavez, Winkler, and their colleagues have pinpointed specific amino acid substitutions in just two viral proteins that are responsible for […] Written by Bioengineer July 8, 2025July 8, 2025 Saving Bookmark this article Bookmarked
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Scientists recreate life’s first step: Linking amino acids to RNA Chemists at UCL have shown how two of biology’s most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of life four billion years ago. Amino acids are the building blocks of proteins, the “workhorses” of life essential to nearly every living process. But proteins cannot replicate or […] Written by Admin August 29, 2025August 29, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked