Biology

  1. Biology

Advances in Radiotherapy for Advanced Lung Cancer

In a groundbreaking meta-analysis published in BMC Cancer, researchers have shed new light on the evolving radiotherapy paradigms for treating locally advanced non-small cell lung cancer (LA-NSCLC), emphasizing innovations that could dramatically alter clinical outcomes. The study meticulously compares high-dose-rate (HDR) brachytherapy, stereotactic body radiotherapy (SBRT), and hypofractionated proton therapy—three cutting-edge modalities within the domain […]
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  1. Biology

Phosphatidic acid drives spatiotemporal distribution of Pex30 at ER-LD contact sites

Lipid droplets (LDs) are ubiquitous neutral lipid storage organelles that form at discrete subdomains in the ER bilayer. The assembly of these ER subdomains and the mechanism by which proteins are recruited to them is poorly understood. Here, we investigate the spatiotemporal distribution of Pex30 at the ER-LD membrane contact sites (MCSs). Pex30, an ER […]
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  1. Biology

Mapping Genetic Risks in Chinese Ovarian Cancer

In a groundbreaking study published in BMC Cancer, researchers have harnessed the power of whole exome sequencing (WES) to unveil the landscape of germline variations associated with ovarian cancer (OC) in a Chinese cohort. The investigation, involving 92 patients, sheds light on the genetic underpinnings of OC predisposition and underscores the potential for personalized medicine […]
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  1. Biology

Pancreatic Cancer Deaths in China: Trends Revealed

Over the past two decades, pancreatic cancer has emerged as a formidable public health challenge worldwide, with mortality rates climbing inexorably. A recent comprehensive study published in BMC Cancer presents a meticulous analysis of pancreatic cancer mortality trends in China from 2004 to 2021. Utilizing robust epidemiological data, this research offers unprecedented insights into how […]
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  1. Biology

Cargo adaptors use a handhold mechanism to engage with myosin V for organelle transport

Myo2, a class V myosin motor, is essential for organelle transport in budding yeast. Its association with cargo is regulated by adaptor proteins that mediate both attachment and release. Vac17, a vacuole-specific adaptor, links Myo2 to the vacuole membrane protein Vac8 and plays a key role in assembling and disassembling the Myo2–Vac17–Vac8 complex during vacuole […]
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  1. Biology

Broad-Spectrum Covalent Inhibitor Targets Coronavirus Mpro

In a groundbreaking leap forward for antiviral drug development, researchers have unveiled a novel covalent inhibitor that shows broad-spectrum efficacy against the main protease (M^pro) of human coronaviruses. This breakthrough illuminates a promising pathway toward universal antiviral therapies that could decisively curtail the threat posed by not only the current SARS-CoV-2 virus but also future […]
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  1. Biology

Anillin links up with RhoA to break the symmetry of cytokinetic ring closure

During animal cell cytokinesis, active RhoA assembles actomyosin-based contractile rings that tend to close asymmetrically. Through imaging C. elegans zygotes, Lebedev et al. (https://doi.org/10.1083/jcb.202405182) reveal that the scaffold protein, anillin, promotes asymmetric ring closure by locally sequestering RhoA from its canonical effectors and thereby limiting actomyosin contractility.
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  1. Biology

Extended Reality Boccia Demonstrates Promising Rehabilitation Benefits

In recent years, the integration of extended reality (XR) technologies into therapeutic and rehabilitation contexts has opened new horizons for enhancing physical and cognitive health, particularly in older adults. A pioneering research group from Osaka Metropolitan University has taken a bold step forward by developing an XR version of boccia, a precision ball sport traditionally […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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