Biology

  1. Biology

Spindle morphology changes between meiosis and mitosis driven by CK2 regulation of the Ran pathway

The transition from meiotic divisions in the oocyte to embryonic mitoses is a critical step in animal development. Despite negligible changes to cell size and shape, following fertilization the small, barrel-shaped meiotic spindle is replaced by a large zygotic spindle that nucleates abundant astral microtubules at spindle poles. To probe underlying mechanisms, we applied a […]
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  1. Biology

Engineering Breast Cancer Cells for Tumor Vaccines

In the rapidly evolving landscape of cancer immunotherapy, a groundbreaking study has emerged from the laboratories of Martí-Díaz et al., poised to redefine therapeutic strategies for breast cancer. Published in the prestigious journal BMC Cancer, this research delves into the sophisticated engineering of phagocytic signals on breast cancer cells ex vivo, proposing a novel whole […]
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  1. Biology

A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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  1. Biology

Dynamic interaction of spliceosomal snRNPs with coilin explains Cajal body characteristics

The Cajal body (CB) is a conserved non-membrane nuclear structure where several steps of small nuclear RNP particle (snRNP) biogenesis take place. It has been proposed that CB formation follows a liquid–liquid phase separation model, but this hypothesis has never been rigorously tested. Here, we applied live-cell imaging to show that the key CB assembly […]
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  1. Biology

Dispersion-Engineered Metasurfaces: Debye Relaxation Unveiled

In the rapidly advancing domain of photonics and metamaterials, researchers continually seek novel pathways to manipulate light with precision and efficiency unachievable by conventional means. A groundbreaking study published in Light: Science & Applications by Ahmed, Qi, and Chen heralds a significant leap forward in our understanding and engineering of metasurfaces, focusing on the integration […]
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  1. Biology

ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway

The Fanconi anemia (FA) DNA repair pathway is required for the repair of DNA interstrand cross-links (ICLs). ICLs are caused by genotoxins, such as chemotherapeutic agents or reactive aldehydes. Inappropriately repaired ICLs contribute to hematopoietic stem cell (HSC) failure and tumorigenesis. While endogenous acetaldehyde and formaldehyde are known to induce HSC failure and leukemia in […]
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  1. Biology

Rising Serum Uric Acid Levels in US Teens

In a comprehensive analysis spanning two decades, researchers have uncovered that serum uric acid (UA) concentrations and the prevalence of hyperuricemia have exhibited remarkable stability among adolescents in the United States. This longitudinal insight, meticulously documented in a recent study published in Pediatric Research, challenges prior assumptions about the possible upward trajectory of serum UA […]
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  1. Biology

The primary cilium as a gatekeeper of FGFR2 function

In this issue, Nita et al. (https://doi.org/10.1083/jcb.202311030) show that the primary cilium regulates FGFR2 signalling through spatial compartmentalization, enabling selective downstream activation. Disruption of ciliary localization in disease-linked FGFR2 variants highlights the role of the cilium as a signalling gatekeeper in development and disease.
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  1. Biology

Blueprint Reveals Pathway for Expanding Australia’s Bioeconomy

Australia stands at the precipice of a major economic transformation, brought to light by a newly released report from Queensland University of Technology (QUT). This thorough investigation emphasizes the urgency for Australia to develop a cohesive national bioeconomy strategy that could harness its rich biological resources. The authors of the report—researchers Madeline Smith, Dr. Jerome […]
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Good Reads

Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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Worlwide

Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed

Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed

A new analysis of the bite strength of 18 species of carnivorous dinosaurs shows that while the Tyrannasaurus rex skull was optimized for quick, strong bites like a crocodile, other giant, predatory dinosaurs that walked on two legs — including spinosaurs and allosaurs — had much weaker bites and instead specialized in slashing and ripping […]
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