Biology Lipid droplets: Open questions and conceptual advances around a unique organelle Once viewed as mere lipid inclusions, the past four decades have witnessed an explosion of research into lipid droplet (LD) biogenesis and function. Pioneering cell biology, biochemical, genetics, and lipidomic studies now reveal LDs as active players in lipid metabolism and cellular homeostasis. Here, we discuss some of the major findings that defined LDs as bona […] Written by Admin September 13, 2025September 13, 2025 Saving Bookmark this article Bookmarked
Biology ABCA7 Variants Alter Neuronal Mitochondria, Phosphatidylcholine In the quest to unravel the intricate ways by which genetic variations influence brain function and neurodegenerative disease, a groundbreaking study has illuminated the pivotal role of the ABCA7 gene in regulating mitochondrial health within neurons. Leveraging cutting-edge genomic and bioenergetic analyses, researchers have unveiled that loss-of-function (LoF) mutations in ABCA7 lead to profound alterations […] Written by Bioengineer September 11, 2025September 11, 2025 Saving Bookmark this article Bookmarked
Biology SEPTIN9 locally activates the RhoGEF ARHGEF18 to promote early stages of mitochondrial fission Mitochondria continually undergo fission to maintain their network and health. Nascent fission sites are marked by the ER, which facilitates actin polymerization to drive calcium flux into the mitochondrion and constrict the inner mitochondrial membrane. Septins are a major eukaryotic cytoskeleton component that forms filaments that can both directly and indirectly modulate other cytoskeleton components, […] Written by Admin September 9, 2025September 9, 2025 Saving Bookmark this article Bookmarked
Biology Pilot Intervention to Support Caregivers of Schizophrenic Seniors Recent research has highlighted a critical but frequently overlooked aspect of mental health care—the impact on family caregivers of older adults diagnosed with schizophrenia. The emotional, psychological, and physical toll on these caregivers can be substantial, as they navigate the complex dynamics of caring for loved ones with mental health issues. A study conducted by […] Written by Bioengineer September 7, 2025September 7, 2025 Saving Bookmark this article Bookmarked
Biology Stu2 performs an essential kinetochore function independent of its microtubule polymerase activity ch-TOG family proteins, including the budding yeast Stu2, are essential for spindle formation and chromosome segregation. Such functions depend on an array of activities ranging from microtubule nucleation, polymerization, and depolymerization to conferring tension sensitivity to kinetochores. This functional diversity makes it challenging to dissect these various functions and understand their relative importance. Here, we […] Written by Admin September 5, 2025September 5, 2025 Saving Bookmark this article Bookmarked
Biology Circuit Links Drive and Social Contact to Mate Neural circuits orchestrate complex behaviors by integrating diverse internal states with external environmental cues. A groundbreaking study published in Nature in 2025 by Salay, Tsao, and Anderson illuminates a previously obscure neural pathway that governs mating behavior in male mice by combining sexual drive with direct social contact, revealing the delicate neurobiological choreography underlying reproductive […] Written by Bioengineer September 4, 2025September 4, 2025 Saving Bookmark this article Bookmarked
Biology Allocation of resources among multiple daughter cells Cell division commonly produces two daughter cells, but there are many exceptions where large cells produce multiple daughters. Multiple fission of some green algae and bacteria; cellularization during embryogenesis of plants and insects; and growth of Ichthyosporeans, Chytrids, and Apicomplexans all provide variations on this theme. In some yeast species, a large multinucleate mother cell […] Written by Admin September 2, 2025September 2, 2025 Saving Bookmark this article Bookmarked
Biology Nomograms Enhance Prognosis in ECMO for Septic Shock In a groundbreaking study, researchers are advancing the field of critical care medicine with the introduction of innovative nomograms designed to predict outcomes for patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) treatment for septic shock. Septic shock remains one of the most severe complications of infections, often leading to multiple organ failure and significant mortality […] Written by Bioengineer August 31, 2025August 31, 2025 Saving Bookmark this article Bookmarked
Biology Submembrane liprin-α1 clusters spatially localize insulin granule fusion Insulin granule fusion in pancreatic β cells localizes to where they contact the ECM of the islet capillaries. The mechanism(s) underpinning localization are unclear. Using glucose or high K+ stimulation or the global uncaging of Ca2+, we show granule fusion consistently focused to the β cell–ECM interface, suggesting a specific localization mechanism. We tested for […] Written by Admin August 29, 2025August 29, 2025 Saving Bookmark this article Bookmarked
Biology Craving, Relapse, and Childhood Trauma: A Network Study In recent years, the global consciousness regarding drug addiction and relapse has expanded considerably, spotlighting the intricate psychological and environmental factors that shape these phenomena. A groundbreaking study published in the International Journal of Mental Health and Addiction by Zhuang, Song, Jin, and colleagues offers a nuanced exploration into the complex interplay between craving, relapse, […] Written by Bioengineer August 27, 2025August 27, 2025 Saving Bookmark this article Bookmarked
Παιχνίδι Snake Online Απολαύστε το online δωρεάν! Δημοσιεύσεις Κλασικός έλεγχος παιχνιδιών Snake '97: ρετρό κινητό τηλέφωνο αντίκα Παιχνίδι Ανάπτυξης Blend Pets Το πρώτο παιχνίδι HTML Snake και εσύ θα JavaScript Καταλήξαμε στο συμπέρασμα ότι έχω δημιουργήσει ένα σετ από μερικά ενημερωμένα παιχνίδια Snake για κινητά, για να σας βοηθήσουμε να κατεβάσετε στο φορητό σας υπολογιστή. Αυτές οι κατηγορίες παιχνιδιών Snake καλύπτουν τα […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
Απολαύστε τα καλύτερα ηλεκτρονικά παιχνίδια πόκερ στο διαδίκτυο, το πραγματικό νόμισμα του 2025 Άρθρα Μορφή Ζωντανού Πράκτορα βήμα 3 Πίστωση Πόκερ μέσω Διαδικτύου Στοιχήματα Πόκερ με πιστωτική κάρτα στο διαδίκτυο – Ποντάρισμα Ante Διαδικτυακό πόκερ, καζίνο, αθλητικές εκδηλώσεις και πληροφορίες για τυχερά παιχνίδια, ιστολόγια και πολλά άλλα. Πονταρίσματα στο βήμα 3, χαρτιά, καζίνο πόκερ Αυτός είναι ο λόγος για τον οποίο τα offline καζίνο σας λένε ότι απολαμβάνουν […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
Παιχνίδι Snake Online Απολαύστε το online δωρεάν! Δημοσιεύσεις Κλασικός έλεγχος παιχνιδιών Snake '97: ρετρό κινητό τηλέφωνο αντίκα Παιχνίδι Ανάπτυξης Blend Pets Το πρώτο παιχνίδι HTML Snake και εσύ θα JavaScript Καταλήξαμε στο συμπέρασμα ότι έχω δημιουργήσει ένα σετ από μερικά ενημερωμένα παιχνίδια Snake για κινητά, για να σας βοηθήσουμε να κατεβάσετε στο φορητό σας υπολογιστή. Αυτές οι κατηγορίες παιχνιδιών Snake καλύπτουν τα […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
Απολαύστε τα καλύτερα ηλεκτρονικά παιχνίδια πόκερ στο διαδίκτυο, το πραγματικό νόμισμα του 2025 Άρθρα Μορφή Ζωντανού Πράκτορα βήμα 3 Πίστωση Πόκερ μέσω Διαδικτύου Στοιχήματα Πόκερ με πιστωτική κάρτα στο διαδίκτυο – Ποντάρισμα Ante Διαδικτυακό πόκερ, καζίνο, αθλητικές εκδηλώσεις και πληροφορίες για τυχερά παιχνίδια, ιστολόγια και πολλά άλλα. Πονταρίσματα στο βήμα 3, χαρτιά, καζίνο πόκερ Αυτός είναι ο λόγος για τον οποίο τα offline καζίνο σας λένε ότι απολαμβάνουν […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
Ήμασταν ο Τσάρλι Κερκ Ιστολόγια Παγκόσμιες ιστοσελίδες καζίνο πόκερ στο διαδίκτυο Caesars Castle Internet casino – Παρέχει επίσης τις ίδιες πληρωμές μέσω PayPal Wahoo: Το νέο παιχνίδι Marble Board Οδηγός αυτοβοήθειας για την εύρεση των κατάλληλων online καζίνο PayPal Οι συνολικές πισίνες τιμής κατά μήκος ολόκληρου του κύκλου μακριά από τις αίθουσες χαρτοπαικτικών λεσχών, αν και όχι, είναι πολύ […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked