Biology

  1. Biology

High-resolution mapping of the actin fusion focus reveals myosin V–dependent formin transport for aster formation

Many processes such as polarized growth and secretion require specific actin networks. In fungi, cell–cell fusion requires cell wall digestion mediated by local secretion of lytic enzymes. In Schizosaccharomyces pombe, the myosin V Myo52 transports enzyme-containing secretory vesicles on the actin fusion focus, an aster-like actin network assembled by the condensate-forming formin Fus1. The fusion […]
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  1. Biology

Dexmedetomidine Enhances Neurocognitive Recovery in Aged Mice

In a groundbreaking study published in BMC Neuroscience, researchers have unveiled the remarkable effects of dexmedetomidine pretreatment on neurocognitive recovery in aged mice following surgical procedures. This research, led by scientists Q. Zhang, S. Hao, and G. Wang, sheds light on the intricate mechanisms at play in the aging brain and their implications for enhancing […]
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  1. Biology

Is the Parkinson’s-associated protein TMEM175 a proton channel: Yay or nay?

The abnormal protein degradation implicated in the pathogenesis of Parkinson’s disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K+ channel, minimally permeable to H+.
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  1. Biology

Luedeking-Piret Model Advances Multi-Step mAb Forecasting

In the rapidly evolving landscape of biopharmaceutical manufacturing, monoclonal antibodies (mAbs) have surged to the forefront as indispensable therapeutic agents. Their complex production processes, however, pose significant engineering challenges, particularly in predicting yield and quality over multi-step production sequences. A recent groundbreaking study by Wang, Verma, Chiu, and colleagues, published in Communications Engineering in 2025, […]
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  1. Biology

Bacterial CipB is an exogenous receptor to drive the mitophagy-TFEB axis and promote pathogenesis

Mitophagy transports mitochondria to lysosomes for degradation to maintain energy homeostasis, inflammation, and immunity. Here, we identify CipB, a type III secretion system (T3SS) effector from Chromobacterium violaceum, as a novel exogenous mitophagy receptor. CipB targets mitochondria by the mitochondrial protein TUFM and recruits autophagosomes via its LC3-interacting region (LIR) motifs. This process initiates the […]
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  1. Biology

Tumor Microenvironment Effects in Liver Cancer Outcomes

In the realm of cancer research, the understanding of tumor microenvironments continues to evolve, offering deeper insights into how various cellular components interact and influence cancer progression. One of the most intriguing areas of investigation is the role of tertiary lymphoid structures (TLS) and cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma (HCC), particularly in cases complicated […]
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  1. Biology

Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis

Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood. Using Caenorhabditiselegans Katanin, which contains the MEI-1 catalytic AAA+ p60 and MEI-2 p80-like regulatory subunits, we identify a critical regulatory role of the N-terminal domain […]
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  1. Biology

Evaluating Pseudomonas and Lactiplantibacillus Against Ralstonia

A recent study has shed light on the comparative biosafety and efficacy of two prominent microbial agents, Pseudomonas fluorescens PFS and Lactiplantibacillus plantarum ZPZ, in their battle against the devastating pathogen Ralstonia solanacearum. This microorganism is notorious for causing wilting diseases in a variety of crops, leading to significant agricultural losses worldwide. Recognizing the urgent […]
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  1. Biology

A new probe illuminates endo-lysosomal Ca 2+ measurements: A role for vesicular IP 3 receptors?

In this issue, Calvo et al. (https://doi.org/10.1083/jcb.202410094) report a new bioluminescent Ca2+ probe (ELGA) targeted to acidic endo-lysosomes (ELs) to permit selective and dynamic recording of endo-lysosomal Ca2+ uptake and release. Ca2+ was not only released by canonical EL channels but, surprisingly, by IP3 receptors.
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  1. Biology

Genetic Insights into Sheep Fur Variations Uncovered

Recent advancements in genomic research have illuminated the complex genetic landscape underlying phenotypic traits in animals. A pivotal study led by Liang et al. has delved into the comparative histomorphometric and transcriptomic analysis of pelage variation in sheep. Their research, soon to be published in the esteemed BMC Genomics journal, provides crucial insights into the […]
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Good Reads

New Arabidopsis BIK1 Alleles Confirm Immunity Role

In a groundbreaking study poised to redefine our understanding of plant immunity, researchers have unveiled novel insights into the pivotal roles of the receptor-like cytoplasmic kinases BIK1 and PBL1 in Arabidopsis. These kinases, previously studied primarily through single transfer DNA (T-DNA) insertional mutant alleles, are reaffirmed as central players in the plant’s pattern-triggered immunity (PTI) […]
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Climate Action Costs More in the Global South. Here’s Why. – State of the Planet

Clean energy technologies have become more affordable around the world. Yet for many countries in the Global South, the cost of transitioning to a low-carbon economy remains disproportionately high. But not because the equipment is more expensive: in fact, solar and wind components are often imported at comparable prices around the world, as global manufacturing scale and […]
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Worlwide

New Arabidopsis BIK1 Alleles Confirm Immunity Role

In a groundbreaking study poised to redefine our understanding of plant immunity, researchers have unveiled novel insights into the pivotal roles of the receptor-like cytoplasmic kinases BIK1 and PBL1 in Arabidopsis. These kinases, previously studied primarily through single transfer DNA (T-DNA) insertional mutant alleles, are reaffirmed as central players in the plant’s pattern-triggered immunity (PTI) […]
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Climate Action Costs More in the Global South. Here’s Why. – State of the Planet

Clean energy technologies have become more affordable around the world. Yet for many countries in the Global South, the cost of transitioning to a low-carbon economy remains disproportionately high. But not because the equipment is more expensive: in fact, solar and wind components are often imported at comparable prices around the world, as global manufacturing scale and […]
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