Biology

  1. Biology

CDK4/6 Inhibitors Boost First-Line Breast Cancer Therapy

In an ambitious stride toward optimizing treatment for hormone receptor-positive (HR+)/HER2-negative advanced breast cancer, a recent comprehensive network meta-analysis has brought fresh insights into the comparative efficacy and safety of the four widely used CDK4/6 inhibitors combined with aromatase inhibitors (AI). Published in the upcoming 2025 volume of BMC Cancer, this pioneering study meticulously synthesizes […]
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  1. Biology

Rewrite Longitudinal profiling of low-abundance strains in microbiomes with

The ability to detect and quantify microbiota over time from shotgun metagenomic data has a plethora of clinical, basic science and public health applications. Given these applications, and the observation that pathogens and other taxa of interest can reside at low relative abundance, there is a critical need for algorithms that accurately profile low-abundance microbial […]
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  1. Biology

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

KRAS, a small GTPase involved in cell proliferation and differentiation, frequently gains activating mutations in human cancers. For KRAS to function, it must bind the plasma membrane (PM) via interactions between its membrane anchor and phosphatidylserine (PtdSer). Therefore, depleting PM PtdSer abrogates KRAS PM binding and activity. From a genome-wide siRNA screen to identify genes […]
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  1. Biology

Rising Anal Cancer Rates Most Pronounced Among Older White and Hispanic

In recent years, the landscape of anal cancer incidence in the United States has revealed surprising and concerning trends, with new research uncovering a notable rise among older women, particularly within white and Hispanic populations. This finding challenges longstanding assumptions about the demographics traditionally considered at highest risk for this rare but serious malignancy, prompting […]
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  1. Biology

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and cytokinesis completion

In animal cells, cleavage furrow formation is controlled by localized activation of the GTPase RhoA at the equatorial membrane using cues transmitted from the spindle. Here, we explore the function of LIN-5, a well-studied protein known for its role in aster separation and spindle positioning in cleavage furrow formation. We show that the cortical pool […]
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  1. Biology

Lanthanide–Nickel Complexes with Ligand-Free Ni2− Anion

In a groundbreaking development at the crossroads of inorganic chemistry and materials science, researchers have unveiled a novel class of lanthanide–nickel molecular intermetallic complexes that push the boundaries of traditional transition metal chemistry. Central to this discovery is the stabilization of a notoriously elusive species: a ligand-free nickel anion bearing a formal negative oxidation state […]
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  1. Biology

A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome

Basement membranes (BMs) are specialized extracellular matrix (ECM) structures essential for organ morphogenesis, architecture, and function. BM composition and properties vary between tissues, developmental stages, and disease states, and there is only a rudimentary understanding of BM dynamics. Here, we introduce a versatile mouse model carrying a multifunctional dual-color fluorescence tagged allele with knockout potential […]
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  1. Biology

Low-Intensity Practices Optimize Agricultural Soil Health

In an era where global food security and environmental sustainability have become pressing challenges, groundbreaking research from the Netherlands Institute of Ecology (NIOO-KNAW) reveals compelling insights into soil management practices that could revolutionize agricultural productivity and sustainability. Published today in the prestigious journal Science, this extensive study demonstrates that reducing the intensity of soil management, […]
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  1. Biology

TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling

Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging.
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  1. Biology

Unraveling Their Role in Driving Brain Cancer

A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […]
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Good Reads

A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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Worlwide

A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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