Biology

  1. Biology

Visualizing nuclear pore complex plasticity with pan-expansion microscopy

The exploration of cell-type and environmentally responsive nuclear pore complex (NPC) plasticity requires new, accessible tools. Using pan-expansion microscopy (pan-ExM), NPCs were identified by machine learning–facilitated segmentation. They exhibited a large range of diameters with a bias for dilated NPCs at the basal nuclear surface in clusters suggestive of local islands of nuclear envelope tension. […]
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  1. Biology

Rewrite Repurposing the memory-promoting meclofenoxate hydrochloride as a

Zhang, H., Fan, C., Li, L. et al. Repurposing the memory-promoting meclofenoxate hydrochloride as a treatment for Parkinson’s disease through integrative multi-omics analysis.npj Parkinsons Dis. 11, 167 (2025). bu içeriği en az 2500 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin […]
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  1. Biology

Appendix Cancer Rates Quadruple Among Older Millennials, New Study Reveals

A groundbreaking new epidemiological study has unveiled an unexpected surge in the incidence of appendiceal adenocarcinoma (AA), a rare form of appendix cancer, in recent American birth cohorts. Employing robust population-based cancer registry data from the National Cancer Institute’s SEER (Surveillance, Epidemiology, and End Results) Program, researchers conducted a comprehensive birth cohort analysis spanning several […]
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  1. Biology

EGFR Stops α-Synuclein Clumps via DNAJB1

In a groundbreaking advance in the battle against Parkinson’s disease, researchers have unveiled a novel molecular pathway through which the epidermal growth factor receptor (EGFR) acts to mitigate one of the disease’s most destructive features: the aggregation of α-synuclein proteins in neuronal cells. This discovery shines new light on the intricate molecular dance that governs […]
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  1. Biology

Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity

Stereocilia are rod-like mechanosensory projections consisting of unidirectionally oriented actin filaments that extend into the inner ear hair cell cytoskeleton, forming dense rootlets. Taperin (TPRN) localizes to the narrowed-down base of stereocilia, where they pivot in response to sound and gravity. We show that TPRN–deficient mice have progressive deafness characterized by gradual asynchronous retraction and […]
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  1. Biology

Remote Detection of Dizziness and Balance Disorders: AI’s New Role in

Artificial intelligence (AI) continues to revolutionize various fields, and healthcare is no exception. This transformative technology is increasingly making significant inroads in medical diagnostics, particularly in the interpretation of complex medical images. This approach helps clinicians better assess disease severity, formulate treatment plans, and monitor patient progress over time. Despite the rapid advancements in AI, […]
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  1. Biology

Deep Learning Enhances Polygenic Score Accuracy

In recent years, the field of genomics has witnessed remarkable advancements driven by the integration of artificial intelligence, particularly deep learning, with traditional genetic analyses. Among the most promising applications is the enhancement of polygenic scores, which estimate an individual’s susceptibility to various diseases by aggregating the effects of numerous genetic variants. A groundbreaking study […]
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  1. Biology

Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs

Acquisition of nonprofessional phagocytic cell fate plays an important role in sculpting functional metazoan organs and maintaining overall tissue homeostasis. Though physiologically highly relevant, how the normal epithelial cells acquire phagocytic fate is still mostly unclear. We have employed the Drosophila ovary model to demonstrate that the classical ecdysone signaling in the somatic epithelial follicle […]
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  1. Biology

Unlocking the Complete Power of Multiferroic Materials for Next-Generation

In a remarkable advancement for the realm of magnetic memory technologies, researchers at the Institute of Science Tokyo have unveiled a groundbreaking discovery regarding the behavior of multiferroic materials. Led by Assistant Professor Kei Shigematsu and Specially Appointed Associate Professor Hena Das, this innovative study challenges long-standing assumptions about the mechanisms of magnetization in such […]
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Good Reads

Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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Worlwide

Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed

Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed

A new analysis of the bite strength of 18 species of carnivorous dinosaurs shows that while the Tyrannasaurus rex skull was optimized for quick, strong bites like a crocodile, other giant, predatory dinosaurs that walked on two legs — including spinosaurs and allosaurs — had much weaker bites and instead specialized in slashing and ripping […]
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