Biology

  1. Biology

ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13

Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational levels. In this study, we employed the CRISPR/Cas9-based screening of a ubiquitin ligase library to identify regulators of human peroxisomes. We discovered that ZBTB17 (MIZ1) […]
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  1. Biology

PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways

Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
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  1. Biology

Manufacturing Firms React to Randomized Energy Audits

In the quest to improve energy efficiency within manufacturing sectors of developing economies, researchers have increasingly turned to energy audits as a potential lever for change. These audits, designed to offer firms tailored insights into their energy usage and opportunities for cost reductions, represent one of the pivotal interventions aiming to balance environmental goals with […]
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  1. Biology

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

Intracellular transport among organellar compartments occurs in two general ways: by membrane-bound carriers and membrane contacts. Specific circumstances that involve the coordination of these two modes of transport remain to be defined. By studying coat protein I (COPI) transport, we find that phosphatidylcholine with short acyl chains (sPC) is delivered through membrane contact from the […]
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  1. Biology

Key Genes Linked to Parkinson’s Disease Discovered Using CRISPR

A recent groundbreaking study conducted by researchers at Northwestern Medicine has unveiled new insights into the complex interplay of genetics responsible for the risk of developing Parkinson’s disease (PD). The study, utilizing advanced CRISPR interference technology, meticulously scanned the entirety of the human genome, unveiling an unrecognized panel of genes pivotal to the disease’s pathogenesis. […]
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  1. Biology

ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates

Protein aggregates are degraded by both the autophagy–lysosomal and the ubiquitin–proteasome pathways. Macroautophagy and microautophagy, two forms of the autophagy–lysosomal pathway, are widely conserved across eukaryotes. While macroautophagy has been extensively studied in the context of degradation of protein aggregates, microautophagy remains less explored. Here, we identify the UBAP1-containing ESCRT-I complex and PTPN23 as new […]
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  1. Biology

Dr. Romina Mizrahi Explores the Role of

In a significant advancement in the field of psychiatric research, Dr. Romina Mizrahi, a prominent figure at McGill University and the Douglas Research Center in Canada, is advocating for the integration of molecular-level analyses in understanding mental health disorders. Her work emphasizes the vital role of positron emission tomography (PET) in psychiatric medicine, aiming to […]
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  1. Biology

The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling

Precise output from the conserved Notch signaling pathway governs a plethora of cellular processes and developmental transitions. Unlike other pathways that use a cytoplasmic relay, the Notch cell surface receptor transduces signaling directly to the nucleus, with endocytic trafficking providing critical regulatory nodes. Here we report that the cytoplasmic tyrosine kinase Abelson (Abl) facilitates Notch […]
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  1. Biology

Exploring Who Bears the Cost of Portal Messaging Among Older Adults and

In the rapidly evolving landscape of healthcare technology, the ability for older adults to communicate with their healthcare providers through digital means has transformed how medical interactions occur. Historically, this demographic relied heavily on phone calls to communicate health concerns, with even simple inquiries often necessitating an in-person visit. As the healthcare field shifts towards […]
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Good Reads

Mammals didn't walk upright until late—here's what fossils reveal

Mammals didn’t walk upright until late—here’s what fossils reveal

For over a century, scientists have puzzled over a fundamental mystery in our evolutionary history: how did mammals go from sprawling like lizards to striding like cats and dogs? This transition — from a sprawled stance (like a lizard) to an upright (parasagittal) posture — marked a pivotal moment in mammal evolution. While the earliest […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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Worlwide

Mammals didn't walk upright until late—here's what fossils reveal

Mammals didn’t walk upright until late—here’s what fossils reveal

For over a century, scientists have puzzled over a fundamental mystery in our evolutionary history: how did mammals go from sprawling like lizards to striding like cats and dogs? This transition — from a sprawled stance (like a lizard) to an upright (parasagittal) posture — marked a pivotal moment in mammal evolution. While the earliest […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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