Biology SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Biology Disordered Interfacial Water Boosts Electrochemical C–C Coupling In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […] Written by Bioengineer August 6, 2025August 6, 2025 Saving Bookmark this article Bookmarked
Biology Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube In this issue, Kim et al. (https://doi.org/10.1083/jcb.202409078) report that the scaffold protein Arc acts through Crumbs to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Drosophila salivary gland. This restriction is needed for a long, thin tube to form. Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked
Biology Dental Stem Cells Differentiate on Biodentine Nanofibers In a groundbreaking advance within the field of regenerative medicine, researchers have unveiled a novel approach to enhance dental and bone tissue engineering by leveraging the unique properties of dental pulp stem cells (DPSCs) cultured on specially designed polymer nanofibers. The study, recently published in BioMedical Engineering OnLine, explores the odontogenic and osteogenic potential of […] Written by Bioengineer August 2, 2025August 2, 2025 Saving Bookmark this article Bookmarked
Biology AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact Membrane contact sites (MCSs) establish organelle interactomes in cells to enable communication and exchange of materials. Volume EM (vEM) is ideally suited for MCS analyses, but semantic segmentation of large vEM datasets remains challenging. Recent adoption of artificial intelligence (AI) for segmentation has greatly enhanced our analysis capabilities. However, we show that organelle boundaries, which […] Written by Admin July 31, 2025July 31, 2025 Saving Bookmark this article Bookmarked
Biology Merbecovirus S2 Vaccines Trigger Cross-Reactive MERS Protection In a groundbreaking study recently published in npj Viruses, a team of researchers led by Halfmann and colleagues has unveiled promising new insights into vaccine design against Merbecoviruses, a subgenus of coronaviruses that includes the Middle East Respiratory Syndrome coronavirus (MERS-CoV). Their work focuses on the S2 subunit of the spike (S) glycoprotein, a component […] Written by Bioengineer July 30, 2025July 30, 2025 Saving Bookmark this article Bookmarked
Biology Tubulin isotypes contribute opposing properties to balance anaphase spindle morphogenesis Faithful chromosome segregation requires proper function of the mitotic spindle, which is built from, and depends on, the coordinated regulation of many microtubules and the activities of molecular motors and MAPs. In addition, microtubules themselves are assembled from multiple variants, or isotypes of α- and β-tubulin, yet whether they mediate the activities of motors and […] Written by Admin July 28, 2025July 28, 2025 Saving Bookmark this article Bookmarked
Biology Ancient Texts Decoded by Neural Networks In a groundbreaking fusion of ancient history and cutting-edge artificial intelligence, researchers have unveiled Aeneas, a sophisticated machine learning model designed to revolutionize the study of Latin inscriptions. This technological marvel aims to assist historians by restoring fragmented texts, dating undocumented carvings, and pinpointing their geographic origins within the vast expanse of the Roman Empire. […] Written by Bioengineer July 26, 2025July 26, 2025 Saving Bookmark this article Bookmarked
Biology The Unkempt RNA-binding protein reveals a local translation program in centriole overduplication Excess centrosomes cause defects in mitosis, cell-signaling, and cell migration, and therefore their assembly is tightly regulated. The divergent Polo kinase, PLK4, controls centriole duplication at the heart of centrosome assembly, and elevated PLK4 levels promote centrosome amplification (CA), a founding event of tumorigenesis. Here, we investigate the transcriptional consequences of elevated PLK4 and find […] Written by Admin July 24, 2025July 24, 2025 Saving Bookmark this article Bookmarked
Biology Additive Manufacturing of Monolithic Gyroidal Solid Oxide Cells In a transformative leap that challenges longstanding constraints in energy conversion technology, researchers have unveiled a groundbreaking design paradigm for solid oxide cells (SOCs) that dramatically enhances their efficiency, durability, and structural integration. Traditional SOCs, fundamental devices capable of interconverting chemical energy and electricity at high temperatures, have been largely limited by planar, two-dimensional (2D) […] Written by Bioengineer July 23, 2025July 23, 2025 Saving Bookmark this article Bookmarked
احجز بعيدًا عن Ra Wonders العب مجانًا أو بأموال حقيقية محتوى أفضل لعبة فيديو بأموال حقيقية جهّز أدواتك وابدأ في الدوران اليوم رمز ترويجي لكازينو Caesars Palace على الإنترنت ويمكنك تقديم التحية كيف ستقوم بتقييم الدورات المجانية الخاصة بـ Ra؟ رغم أن نصائحك قد تُحسّن من تجربتك، إلا أنها لا تضمن لك عوائد مضمونة. استمتع باللعبة الإلكترونية بذكاء، واستمتع باستكشاف كنوز لعبة الفيديو سلوتس الرائعة. […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
أفضل مواقع البلاك جاك على الإنترنت للعب بأموال حقيقية في عام 2025 المدونات أفضل تطبيقات الكازينو التي يمكنك من خلالها دفع أموال حقيقية في عام 2025 تطبيق كازينو كريزي إجراءات الرسوم التقليدية: رسوم البطاقات والتحويلات المالية بالإضافة إلى تقديم العروض، يمكنك طلب المكافآت، والتواصل مع خدمة العملاء، ثم إيداع الأموال وتوزيعها على التطبيق. يتميز برنامج كازينو الإنترنت الجديد المُحدّث ببحث مُختلف وتصميم متعدد الصالات. تم إطلاقه في […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
احجز بعيدًا عن Ra Wonders العب مجانًا أو بأموال حقيقية محتوى أفضل لعبة فيديو بأموال حقيقية جهّز أدواتك وابدأ في الدوران اليوم رمز ترويجي لكازينو Caesars Palace على الإنترنت ويمكنك تقديم التحية كيف ستقوم بتقييم الدورات المجانية الخاصة بـ Ra؟ رغم أن نصائحك قد تُحسّن من تجربتك، إلا أنها لا تضمن لك عوائد مضمونة. استمتع باللعبة الإلكترونية بذكاء، واستمتع باستكشاف كنوز لعبة الفيديو سلوتس الرائعة. […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
أفضل مواقع البلاك جاك على الإنترنت للعب بأموال حقيقية في عام 2025 المدونات أفضل تطبيقات الكازينو التي يمكنك من خلالها دفع أموال حقيقية في عام 2025 تطبيق كازينو كريزي إجراءات الرسوم التقليدية: رسوم البطاقات والتحويلات المالية بالإضافة إلى تقديم العروض، يمكنك طلب المكافآت، والتواصل مع خدمة العملاء، ثم إيداع الأموال وتوزيعها على التطبيق. يتميز برنامج كازينو الإنترنت الجديد المُحدّث ببحث مُختلف وتصميم متعدد الصالات. تم إطلاقه في […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
برامج MoneyTime للعب وتحقيق الدخل عبر الإنترنت دعامات وصف كامل لـ 23 لعبة فلاش عبر الإنترنت يمكنك لعبها بأموال حقيقية العاب المال وكذلك شخص ما يعرف عن عجل العملة ألعاب مع هذه البرامج يمكنك إنفاقها عبر PayPal صُممت هذه الأنواع من الألعاب للتدريب التجريبي، مع تقديم مكافآت نقدية للمتفوقين. تُقام مسابقات حية في العديد من ألعاب التوافه، حيث تنزيل تطبيق تحديث tusk […] Written by yam3t3 October 19, 2025October 19, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked