Biology

  1. Biology

CDK4/6 Inhibitors Boost First-Line Breast Cancer Therapy

In an ambitious stride toward optimizing treatment for hormone receptor-positive (HR+)/HER2-negative advanced breast cancer, a recent comprehensive network meta-analysis has brought fresh insights into the comparative efficacy and safety of the four widely used CDK4/6 inhibitors combined with aromatase inhibitors (AI). Published in the upcoming 2025 volume of BMC Cancer, this pioneering study meticulously synthesizes […]
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  1. Biology

Rewrite Longitudinal profiling of low-abundance strains in microbiomes with

The ability to detect and quantify microbiota over time from shotgun metagenomic data has a plethora of clinical, basic science and public health applications. Given these applications, and the observation that pathogens and other taxa of interest can reside at low relative abundance, there is a critical need for algorithms that accurately profile low-abundance microbial […]
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  1. Biology

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

KRAS, a small GTPase involved in cell proliferation and differentiation, frequently gains activating mutations in human cancers. For KRAS to function, it must bind the plasma membrane (PM) via interactions between its membrane anchor and phosphatidylserine (PtdSer). Therefore, depleting PM PtdSer abrogates KRAS PM binding and activity. From a genome-wide siRNA screen to identify genes […]
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  1. Biology

Rising Anal Cancer Rates Most Pronounced Among Older White and Hispanic

In recent years, the landscape of anal cancer incidence in the United States has revealed surprising and concerning trends, with new research uncovering a notable rise among older women, particularly within white and Hispanic populations. This finding challenges longstanding assumptions about the demographics traditionally considered at highest risk for this rare but serious malignancy, prompting […]
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  1. Biology

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and cytokinesis completion

In animal cells, cleavage furrow formation is controlled by localized activation of the GTPase RhoA at the equatorial membrane using cues transmitted from the spindle. Here, we explore the function of LIN-5, a well-studied protein known for its role in aster separation and spindle positioning in cleavage furrow formation. We show that the cortical pool […]
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  1. Biology

Lanthanide–Nickel Complexes with Ligand-Free Ni2− Anion

In a groundbreaking development at the crossroads of inorganic chemistry and materials science, researchers have unveiled a novel class of lanthanide–nickel molecular intermetallic complexes that push the boundaries of traditional transition metal chemistry. Central to this discovery is the stabilization of a notoriously elusive species: a ligand-free nickel anion bearing a formal negative oxidation state […]
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  1. Biology

A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome

Basement membranes (BMs) are specialized extracellular matrix (ECM) structures essential for organ morphogenesis, architecture, and function. BM composition and properties vary between tissues, developmental stages, and disease states, and there is only a rudimentary understanding of BM dynamics. Here, we introduce a versatile mouse model carrying a multifunctional dual-color fluorescence tagged allele with knockout potential […]
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  1. Biology

Low-Intensity Practices Optimize Agricultural Soil Health

In an era where global food security and environmental sustainability have become pressing challenges, groundbreaking research from the Netherlands Institute of Ecology (NIOO-KNAW) reveals compelling insights into soil management practices that could revolutionize agricultural productivity and sustainability. Published today in the prestigious journal Science, this extensive study demonstrates that reducing the intensity of soil management, […]
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  1. Biology

TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling

Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging.
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Good Reads

Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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Worlwide

Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed

Crushing vs. Slashing: New skull scans reveal how giant dinosaurs killed

A new analysis of the bite strength of 18 species of carnivorous dinosaurs shows that while the Tyrannasaurus rex skull was optimized for quick, strong bites like a crocodile, other giant, predatory dinosaurs that walked on two legs — including spinosaurs and allosaurs — had much weaker bites and instead specialized in slashing and ripping […]
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