Biology

  1. Biology

Unlocking Wild Apple’s Genomics Through Transcriptome Profiling

In a groundbreaking study published in the journal Discover Plants, researchers have unveiled a comprehensive analysis of the genomic resources of the lesser-known wild apple species, Docynia indica (Wall.) Decne. This research represents a significant milestone in plant genomics, shining a light on the genetic basis of traits that could enhance apple cultivation, disease resistance, […]
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  1. Biology

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Protein trafficking within the endosomal system involves several distinct membrane remodeling events, including those with opposing orientations that lead to the production of intraluminal vesicles (ILVs) and recycling tubules. Components of the endosomal sorting complex required for transport (ESCRT) machinery have been implicated in both pathways, although few studies have directly examined their native dynamics […]
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  1. Biology

Questionnaires for Assessing Patient Preferences in Consultations

In the evolving landscape of healthcare, the significance of patient-provider consultations cannot be overstated. As the paradigm shifts towards a more patient-centered approach, the need for effective communication and understanding between patients and healthcare providers has become increasingly critical. A recent study conducted by a team of researchers, including Bambas, A.Z., Wahidie, D., and Yilmaz-Aslan, […]
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  1. Biology

Can Targeting Inflammation Alleviate Fatigue in Early-Stage Breast Cancer

Emerging research from the University of California, Los Angeles (UCLA) illuminates the complex interplay between inflammation and the multifaceted fatigue experienced by women diagnosed with early-stage breast cancer. Fatigue, a pervasive and often debilitating symptom encountered by cancer patients, encompasses not only physical tiredness but extends into cognitive and emotional exhaustion, thereby profoundly diminishing quality […]
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  1. Biology

Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis

Macrophage phagocytosis is an essential immune response that eliminates pathogens, antibody-opsonized cancer cells, and debris. Macrophages can also trogocytose, or nibble, targets. Trogocytosis and phagocytosis are often activated by the same signal, including IgG antibodies. What makes a macrophage trogocytose instead of phagocytose is not clear. Using both CD47 antibodies and a Her2 chimeric antigen […]
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  1. Biology

WindSTAR Secures NSF Grant to Fuel Advancements in AI Research

The University of Texas at Dallas (UTD) has reinforced its commitment to advancing renewable energy research through the Center for Wind Energy Science, Technology and Research, known as WindSTAR. This esteemed center has recently garnered continued federal funding, signaling the importance and relevance of the research being conducted. Established in collaboration with the University of […]
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  1. Biology

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine (N)-linked protein glycosylation. DLO synthesis can be impaired by genetic and environmental factors, leading to the accumulation of various immature DLO intermediates that are subsequently cleaved into phosphorylated oligosaccharides (POSs). Despite the fact that its activity has been known since the 1970s, the identity of the enzyme […]
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  1. Biology

Genomic Study Uncovers Resilience of Coral-Killing Sponge

In the vast and intricate ecosystems of coral reefs, a hidden danger lurks, posing threats not just to the colorful corals themselves but to entire marine environments. Recent research spearheaded by Liu, PY., Chiu, WC., Lim, S.L., and their collaborators has shed light on the mysterious and pervasive sponge known as Terpios hoshinota. This sponge, […]
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  1. Biology

Vacuolar pH regulates clathrin-mediated endocytosis through TORC1 signaling during replicative aging

Clathrin-mediated endocytosis (CME) is a critical cellular process that regulates nutrient uptake, membrane composition, and signaling. Although replicative aging affects many cellular functions, its impact on CME remains largely unknown. We show that in budding yeast, older cells have slower assembly of early and coat CME modules, resulting in longer endocytic turnover and reduced Mup1 […]
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  1. Biology

Genome-wide Study Links REM Sleep Disorder, Parkinson’s

In a groundbreaking genetic study published in the latest issue of npj Parkinson’s Disease, researchers have unveiled new insights into the complex relationship between REM sleep behavior disorder (RBD) and Parkinson’s disease (PD). This seminal work, conducted through a comprehensive genome-wide association study (GWAS), elucidates critical genetic underpinnings that could redefine our understanding of the […]
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Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of […]
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Worlwide

Mitochondrial presequences harbor variable strengths to maintain organellar function

Hundreds of mitochondrial proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphiphilic helices, presequences lack a consensus motif and thus likely promote protein import into mitochondria with variable efficiencies. Indeed, the concept of presequence strength underlies biological models such as stress sensing, yet a quantitative analysis of […]
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Labour’s ‘deeply alarming’ attack on protest rights

British authorities have severely restricted the right to protest in contravention of their international human rights obligations, creating an environment in which peaceful dissent is increasingly treated as a criminal act, Human Rights Watch said in its latest report. ‘Silencing the Streets’: The Right to Protest Under Attack in the UK documents that the UK’s […]
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