Biology

  1. Biology

Unraveling Their Role in Driving Brain Cancer

A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […]
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  1. Biology

ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13

Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational levels. In this study, we employed the CRISPR/Cas9-based screening of a ubiquitin ligase library to identify regulators of human peroxisomes. We discovered that ZBTB17 (MIZ1) […]
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  1. Biology

PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways

Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
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  1. Biology

Manufacturing Firms React to Randomized Energy Audits

In the quest to improve energy efficiency within manufacturing sectors of developing economies, researchers have increasingly turned to energy audits as a potential lever for change. These audits, designed to offer firms tailored insights into their energy usage and opportunities for cost reductions, represent one of the pivotal interventions aiming to balance environmental goals with […]
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  1. Biology

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

Intracellular transport among organellar compartments occurs in two general ways: by membrane-bound carriers and membrane contacts. Specific circumstances that involve the coordination of these two modes of transport remain to be defined. By studying coat protein I (COPI) transport, we find that phosphatidylcholine with short acyl chains (sPC) is delivered through membrane contact from the […]
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  1. Biology

Key Genes Linked to Parkinson’s Disease Discovered Using CRISPR

A recent groundbreaking study conducted by researchers at Northwestern Medicine has unveiled new insights into the complex interplay of genetics responsible for the risk of developing Parkinson’s disease (PD). The study, utilizing advanced CRISPR interference technology, meticulously scanned the entirety of the human genome, unveiling an unrecognized panel of genes pivotal to the disease’s pathogenesis. […]
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  1. Biology

ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates

Protein aggregates are degraded by both the autophagy–lysosomal and the ubiquitin–proteasome pathways. Macroautophagy and microautophagy, two forms of the autophagy–lysosomal pathway, are widely conserved across eukaryotes. While macroautophagy has been extensively studied in the context of degradation of protein aggregates, microautophagy remains less explored. Here, we identify the UBAP1-containing ESCRT-I complex and PTPN23 as new […]
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  1. Biology

Dr. Romina Mizrahi Explores the Role of

In a significant advancement in the field of psychiatric research, Dr. Romina Mizrahi, a prominent figure at McGill University and the Douglas Research Center in Canada, is advocating for the integration of molecular-level analyses in understanding mental health disorders. Her work emphasizes the vital role of positron emission tomography (PET) in psychiatric medicine, aiming to […]
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  1. Biology

The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling

Precise output from the conserved Notch signaling pathway governs a plethora of cellular processes and developmental transitions. Unlike other pathways that use a cytoplasmic relay, the Notch cell surface receptor transduces signaling directly to the nucleus, with endocytic trafficking providing critical regulatory nodes. Here we report that the cytoplasmic tyrosine kinase Abelson (Abl) facilitates Notch […]
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Good Reads

Scientists just cracked the code to editing entire chromosomes flawlessly

Scientists just cracked the code to editing entire chromosomes flawlessly

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […]
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Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Worlwide

Scientists just cracked the code to editing entire chromosomes flawlessly

Scientists just cracked the code to editing entire chromosomes flawlessly

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […]
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Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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