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Extended Reality Boccia Demonstrates Promising Rehabilitation Benefits

In recent years, the integration of extended reality (XR) technologies into therapeutic and rehabilitation contexts has opened new horizons for enhancing physical and cognitive health, particularly in older adults. A pioneering research group from Osaka Metropolitan University has taken a bold step forward by developing an XR version of boccia, a precision ball sport traditionally […]
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  1. Biology

CDK4/6 Inhibitors Boost First-Line Breast Cancer Therapy

In an ambitious stride toward optimizing treatment for hormone receptor-positive (HR+)/HER2-negative advanced breast cancer, a recent comprehensive network meta-analysis has brought fresh insights into the comparative efficacy and safety of the four widely used CDK4/6 inhibitors combined with aromatase inhibitors (AI). Published in the upcoming 2025 volume of BMC Cancer, this pioneering study meticulously synthesizes […]
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Rewrite Longitudinal profiling of low-abundance strains in microbiomes with

The ability to detect and quantify microbiota over time from shotgun metagenomic data has a plethora of clinical, basic science and public health applications. Given these applications, and the observation that pathogens and other taxa of interest can reside at low relative abundance, there is a critical need for algorithms that accurately profile low-abundance microbial […]
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MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

KRAS, a small GTPase involved in cell proliferation and differentiation, frequently gains activating mutations in human cancers. For KRAS to function, it must bind the plasma membrane (PM) via interactions between its membrane anchor and phosphatidylserine (PtdSer). Therefore, depleting PM PtdSer abrogates KRAS PM binding and activity. From a genome-wide siRNA screen to identify genes […]
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  1. Biology

Rising Anal Cancer Rates Most Pronounced Among Older White and Hispanic

In recent years, the landscape of anal cancer incidence in the United States has revealed surprising and concerning trends, with new research uncovering a notable rise among older women, particularly within white and Hispanic populations. This finding challenges longstanding assumptions about the demographics traditionally considered at highest risk for this rare but serious malignancy, prompting […]
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A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and cytokinesis completion

In animal cells, cleavage furrow formation is controlled by localized activation of the GTPase RhoA at the equatorial membrane using cues transmitted from the spindle. Here, we explore the function of LIN-5, a well-studied protein known for its role in aster separation and spindle positioning in cleavage furrow formation. We show that the cortical pool […]
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Lanthanide–Nickel Complexes with Ligand-Free Ni2− Anion

In a groundbreaking development at the crossroads of inorganic chemistry and materials science, researchers have unveiled a novel class of lanthanide–nickel molecular intermetallic complexes that push the boundaries of traditional transition metal chemistry. Central to this discovery is the stabilization of a notoriously elusive species: a ligand-free nickel anion bearing a formal negative oxidation state […]
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A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome

Basement membranes (BMs) are specialized extracellular matrix (ECM) structures essential for organ morphogenesis, architecture, and function. BM composition and properties vary between tissues, developmental stages, and disease states, and there is only a rudimentary understanding of BM dynamics. Here, we introduce a versatile mouse model carrying a multifunctional dual-color fluorescence tagged allele with knockout potential […]
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Low-Intensity Practices Optimize Agricultural Soil Health

In an era where global food security and environmental sustainability have become pressing challenges, groundbreaking research from the Netherlands Institute of Ecology (NIOO-KNAW) reveals compelling insights into soil management practices that could revolutionize agricultural productivity and sustainability. Published today in the prestigious journal Science, this extensive study demonstrates that reducing the intensity of soil management, […]
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Scientists are closing in on Leonardo da Vinci’s DNA

Scientists are closing in on Leonardo da Vinci’s DNA

For over five centuries, Leonardo Da Vinci has been celebrated as a visionary artist, scientist, and inventor, known for his extraordinary talent and groundbreaking experiments. Today, an international collaboration known as the Leonardo DNA Project is closer than ever to uncovering the biological secrets of the greatest genius of the Renaissance. In their new book […]
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Scientists are closing in on Leonardo da Vinci’s DNA

Scientists are closing in on Leonardo da Vinci’s DNA

For over five centuries, Leonardo Da Vinci has been celebrated as a visionary artist, scientist, and inventor, known for his extraordinary talent and groundbreaking experiments. Today, an international collaboration known as the Leonardo DNA Project is closer than ever to uncovering the biological secrets of the greatest genius of the Renaissance. In their new book […]
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NextGen ice breaker Slot Spilleautomater Onlineslots & casinoer 2025

NexGen Gaming utvikler danselåt behandle tiden, i tillegg til har et innovativt andlet og det der leveres frakoblet dans. Det er ei anvendelig blanda drops ikke i bruk kreativitet, funksjonalitet i tillegg til kvalitet igang spillutgivelsene per NextGen Gaming. Bust gleder egen hele tiden per nært gang et nytt danselåt slippes ut. Det er ikke […]
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