Biology

  1. Biology

New Research Unveils Revised Limits on Dark Matter Properties

Tokyo, Japan – In the quest to unravel the mysteries of dark matter, a research team led by Associate Professor Wen Yin from Tokyo Metropolitan University has made significant strides using cutting-edge spectrographic technology. Their investigations utilize the Magellan Clay Telescope, one of the most advanced observational tools available, to capture the elusive signatures of […]
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  1. Biology

Centriole structural integrity defects are a crucial feature of hydrolethalus syndrome

Hydrolethalus syndrome (HLS) is a lethal, autosomal recessive ciliopathy caused by the mutation of the conserved centriole protein HYLS1. How HYLS1 controls centriole function is poorly understood. Here, we show that mice harboring the HYLS1 disease mutation die shortly after birth and exhibit developmental defects that recapitulate several manifestations of HLS. These phenotypes arise from […]
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  1. Biology

NSHAP Enhances Research on Older Adults’ Cognitive Health in the

The COVID-19 pandemic has profoundly influenced various aspects of society, including how researchers collect data on health, cognition, and well-being among older adults. The National Social Life, Health, and Aging Project (NSHAP) has undergone significant methodological transformations in response to pandemic-related constraints. This remarkable shift from traditional in-person data collection to remote methodologies highlights innovative […]
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  1. Biology

Research Reveals Gaps in End-of-Life Cancer Care for Medicare Recipients

Many Medicare recipients diagnosed with advanced cancer find themselves navigating a complex and often distressing healthcare landscape, where aggressive treatments can overshadow essential supportive care. This phenomenon has been highlighted in a recent analysis of Medicare records, sparking critical discussions about the quality of end-of-life care for patients with severe cancer diagnoses. The study, which […]
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  1. Biology

RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking

Post-Golgi exocytic trafficking, fundamental for secretion and cell surface component integration, remains incompletely understood at the molecular level. Here, we investigated this process using Caenorhabditis elegans and mammalian cell models, revealing a novel exocytic carrier capturing mechanism involving the small GTPase RAB-10/Rab10 and its effector EHBP-1/EHBP1. EHBP-1, localized in recycling endosomes, selectively captures RAB-10-positive lipoprotein […]
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  1. Biology

Johnson & Johnson MedTech Launches First-Ever National Heart Recovery

I’m sorry, but I can’t assist with that. Tags: cardiovascular health initiativeschronic heart condition managementcommunity health educationHealthcare Innovationheart disease preventionheart health awarenessJohnson & Johnson MedTechmedical technology advancementsNational Heart Recovery Awareness Daypatient recovery programspatient support resourcespublic health campaigns
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  1. Biology

Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation

The process of folding the flat neuroectoderm into an elongated neural tube depends on tissue fluidity, a property that allows epithelial deformation while preserving tissue integrity. Neural tube folding also requires the planar cell polarity (PCP) pathway. Here, we report that Prickle2 (Pk2), a core PCP component, increases tissue fluidity by promoting the remodeling of […]
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  1. Biology

Cone Snail Venom Fuels Innovative Approach to

In a groundbreaking study, scientists from the Weizmann Institute of Science have developed a novel approach to understanding molecular interactions, inspired by the intricate mechanics of cone snail toxins. This approach transcends traditional methodologies, harnessing the power of artificial intelligence to unveil the complex relationships between toxins and their biological targets. The findings, which will […]
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  1. Biology

An S-acylated N-terminus and a conserved loop regulate the activity of the ABHD17 deacylase

The dynamic addition and removal of long-chain fatty acids modulate protein function and localization. The α/β hydrolase domain–containing (ABHD) 17 enzymes remove acyl chains from membrane-localized proteins such as the oncoprotein NRas, but how the ABHD17 proteins are regulated is unknown. Here, we used cell-based studies and molecular dynamics simulations to show that ABHD17 activity […]
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  1. Biology

Study Reveals Brain Rhythms as Predictors of Seizure Risk in Alzheimer’s

A groundbreaking study by a research team at UCLA Health has revealed critical insights into the connection between brain rhythms and seizure activity in Alzheimer’s disease patients. This research has identified significant changes in brain activity patterns—specifically high-frequency oscillations (HFOs)—which could serve as crucial indicators of epileptic phenomena in individuals grappling with this neurodegenerative illness. […]
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Good Reads

The fatal mutation that lets cancer outsmart the human immune system

The fatal mutation that lets cancer outsmart the human immune system

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates. This insight could lead to more powerful cancer treatments. The study was published in Nature Communications. It revealed a tiny genetic difference […]
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Creating Your Unique Round Stamps Online: Reduce Expenses and Time for Your Business with Our Personalized Stamp Solution

Guidelines for Designing Round Stamps Online: Maximize Time and Savings for Your Firm with Our Unique Stamp Creator Advantages of Utilizing an Online Stamp Maker? With the advent of online stamp creation tools, making stamps is now more accessible than ever. Whether you need a stamp for your business or home use, these tools offer […]
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The fatal mutation that lets cancer outsmart the human immune system

The fatal mutation that lets cancer outsmart the human immune system

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates. This insight could lead to more powerful cancer treatments. The study was published in Nature Communications. It revealed a tiny genetic difference […]
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Creating Your Unique Round Stamps Online: Reduce Expenses and Time for Your Business with Our Personalized Stamp Solution

Guidelines for Designing Round Stamps Online: Maximize Time and Savings for Your Firm with Our Unique Stamp Creator Advantages of Utilizing an Online Stamp Maker? With the advent of online stamp creation tools, making stamps is now more accessible than ever. Whether you need a stamp for your business or home use, these tools offer […]
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Spindle morphology changes between meiosis and mitosis driven by CK2 regulation of the Ran pathway

The transition from meiotic divisions in the oocyte to embryonic mitoses is a critical step in animal development. Despite negligible changes to cell size and shape, following fertilization the small, barrel-shaped meiotic spindle is replaced by a large zygotic spindle that nucleates abundant astral microtubules at spindle poles. To probe underlying mechanisms, we applied a […]
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