Biology

  1. Biology

Structure of the F-tractin–F-actin complex

F-tractin is a peptide widely used to visualize the actin cytoskeleton in live eukaryotic cells but has been reported to impair cell migration and induce actin bundling at high expression levels. To elucidate these effects, we determined the cryo-EM structure of the F-tractin–F-actin complex, revealing that F-tractin consists of a flexible N-terminal region and an […]
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  1. Biology

Mapping Gas Adsorption on Platinum and Gold ‘Crown’ Structures Linked

Tokyo Metropolitan University researchers have made significant strides in understanding the behavior of gases interacting with metal cluster-containing crystalline solids. The study focuses on a unique solid compound, [PtAu8(PPh3)8]-H[PMo12O40], identified as PtAu8-PMo12, demonstrating critical insights into how hydrogen and carbon monoxide are absorbed in structures composed of platinum and gold. Using advanced techniques, including quick-scan […]
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  1. Biology

VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b

Vacuolar protein sorting 41 (VPS41), a component of the homotypic fusion and protein sorting (HOPS) complex for lysosomal fusion, is essential for the trafficking of lysosomal membrane proteins via lysosome-associated membrane protein (LAMP) carriers from the trans-Golgi network (TGN) to endo/lysosomes. However, the molecular mechanisms underlying this pathway and VPS41’s role herein remain poorly understood. […]
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  1. Biology

Optimizing Effective Integration of Artificial

Researchers at Flinders University are making significant strides in healthcare with an innovative approach to integrating artificial intelligence (AI) into emergency medicine. Their recent work focuses on evaluating a cardiac AI tool named RAPIDx, which has been tested in various hospitals across South Australia. The goal is clear: to determine whether this AI system can […]
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  1. Biology

Bennu’s Dual-Chirality Amino Acids Spark

NASA’s OSIRIS‑REx mission has ushered in a new era in our understanding of prebiotic chemistry and the dynamic nature of small Solar System bodies by returning pristine samples from the near‑Earth asteroid Bennu. In a groundbreaking development that challenges long‑standing assumptions regarding the origins of life on our planet, researchers have discovered that Bennu’s fragments […]
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  1. Biology

Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment

Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved and what is their functional significance in tissue morphogenesis and maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) in orchestrating fate decisions in skin epidermis. […]
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  1. Biology

Groundbreaking Discovery by Durham University Scientists in Predicting and

Researchers at Durham University have made significant strides in understanding the intricate relationship between proteins and metal binding in cellular environments, a vital process that underpins many biological functions essential for life. This groundbreaking research, recently published in Nature Communications, unveils an innovative methodology allowing scientists to accurately forecast and engineer the binding of metals […]
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  1. Biology

FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

Mitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have “intergenomic signaling” pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes encoded by mtDNA. However, MRS pathways that sense the amount […]
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  1. Biology

Enhanced Survival Rates Observed with Anatomic Lung Resection in

New research unveiled at the 2025 Society of Thoracic Surgeons (STS) Annual Meeting has significant implications for the surgical treatment outcomes in patients diagnosed with early-stage non-small cell lung cancer (NSCLC). This study examines the long-term survival rates associated with different surgical approaches, particularly anatomic lung resections like lobectomy and segmentectomy, in contrast to wedge […]
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Good Reads

Six Exposure Science Principles Advancing Healthy Environments

Six Exposure Science Principles Advancing Healthy Environments

In the evolving landscape of environmental health, understanding the intricate ways in which humans interact with their surroundings is paramount. Exposure science, a discipline that discerns how individuals come into contact with environmental agents, stands at the forefront of this endeavor. A recent seminal publication by E.A. Cohen Hubal delineates six foundational principles of exposure […]
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The fatal mutation that lets cancer outsmart the human immune system

The fatal mutation that lets cancer outsmart the human immune system

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates. This insight could lead to more powerful cancer treatments. The study was published in Nature Communications. It revealed a tiny genetic difference […]
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Worlwide

Six Exposure Science Principles Advancing Healthy Environments

Six Exposure Science Principles Advancing Healthy Environments

In the evolving landscape of environmental health, understanding the intricate ways in which humans interact with their surroundings is paramount. Exposure science, a discipline that discerns how individuals come into contact with environmental agents, stands at the forefront of this endeavor. A recent seminal publication by E.A. Cohen Hubal delineates six foundational principles of exposure […]
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The fatal mutation that lets cancer outsmart the human immune system

The fatal mutation that lets cancer outsmart the human immune system

New research from UC Davis Comprehensive Cancer Center has uncovered an evolutionary change that may explain why certain immune cells in humans are less effective at fighting solid tumors compared to non-human primates. This insight could lead to more powerful cancer treatments. The study was published in Nature Communications. It revealed a tiny genetic difference […]
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Creating Your Unique Round Stamps Online: Reduce Expenses and Time for Your Business with Our Personalized Stamp Solution

Guidelines for Designing Round Stamps Online: Maximize Time and Savings for Your Firm with Our Unique Stamp Creator Advantages of Utilizing an Online Stamp Maker? With the advent of online stamp creation tools, making stamps is now more accessible than ever. Whether you need a stamp for your business or home use, these tools offer […]
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