Biology

  1. Biology

Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase

Proteostasis involves degradation and recycling of proteins from organelles, membranes, and multiprotein complexes. These processes can depend on protein extraction and unfolding by the essential mechanoenzyme valosin-containing protein (VCP) and on ubiquitin chain remodeling by ubiquitin-specific proteases known as deubiquitinases (DUBs). How the activities of VCP and DUBs are coordinated is poorly understood. Here, we […]
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  1. Biology

Revolutionary Approaches to Amplify Chiral Optical Signals Revealed

In the intricate world of molecular science, chiral molecules exhibit a fascinating property that has profound implications in fields ranging from organic chemistry to pharmacology. The unique hand-in-hand form of chiral molecules—where one form exists as a mirror image of another—makes chirality a subject of intense research and exploration. A landmark publication in the esteemed […]
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  1. Biology

Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

CIZ1 is part of the RNA-dependent supramolecular assemblies that form around the inactive X-chromosome (Xi) in female cells and smaller assemblies throughout the nucleus in both sexes. Here, we show that CIZ1 C-terminal anchor domain (AD) is elevated in human breast tumor transcriptomes, even at stage I. Elevation correlates with deprotection of chromatin and upregulation […]
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  1. Biology

Unveiling a New Name for One of the World’s Rarest Rhinoceros Species

A groundbreaking study spearheaded by renowned zoologist Francesco Nardelli and esteemed paleontologist Kurt Heißig has brought to light significant evolutionary distinctions between two prominent one-horned rhinoceros species: the Indian rhinoceros, scientifically known as Rhinoceros unicornis, and its Sundaic counterpart, Rhinoceros sondaicus. This research challenges long-accepted classifications and underscores the necessity for a reevaluation of these […]
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  1. Biology

Vacuoles provide the source membrane for TORC1-containing signaling endosomes

Organelle biogenesis is fundamental to eukaryotic cell biology. Yeast signaling endosomes were recently identified as a signaling platform for the evolutionarily conserved Target of Rapamycin Complex 1 (TORC1) kinase complex. Despite the importance of signaling endosomes for TORC1-mediated control of cellular metabolism, how this organelle is generated has been a mystery. Here, we developed a […]
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  1. Biology

Exploring New Frontiers in AI Through Knowledge,

A recent publication in the esteemed journal Engineering has sparked conversations in the field of artificial intelligence (AI) by outlining a compelling vision for the future beyond large language models (LLMs). The current wave of LLMs has showcased impressive capabilities in performing a variety of tasks across different modalities. However, researchers have recognized the inherent […]
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  1. Biology

Ca 2+ binding to Esyt modulates membrane contact site density in Drosophila photoreceptors

Membrane contact sites (MCS) between the plasma membrane (PM) and endoplasmic reticulum (ER) regulate Ca2+ influx. However, the mechanisms by which cells modulate ER–PM MCS density are not understood, and the role of Ca2+, if any, in regulating these is unknown. We report that in Drosophila photoreceptors, MCS density is regulated by the Ca2+ channels, […]
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  1. Biology

New Exoplanet Candidate Discovered Beyond Our Solar System

In a groundbreaking development in the field of exoplanet research, scientists at the University of New South Wales (UNSW) Sydney have identified a potential new exoplanet using an advanced method known as transit timing variation. For those who may not be familiar, an exoplanet is any planet that exists outside of our solar system, often […]
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  1. Biology

The pathway of unconventional protein secretion involves CUPS and a modified trans-Golgi network

Compartment for unconventional protein secretion (CUPS), a compartment for secretion of signal sequence–lacking proteins, forms through COPI-independent extraction of membranes from early Golgi cisternae, lacks Golgi-specific glycosyltransferases, and requires phosphatidylinositol 4-phosphate (PI4P) for biogenesis, as well as phosphatidylinositol 3-phosphate for stability. Our findings demonstrate that Drs2, a PI4P effector from the trans-Golgi network (TGN), is […]
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  1. Biology

New Research Unveils Revised Limits on Dark Matter Properties

Tokyo, Japan – In the quest to unravel the mysteries of dark matter, a research team led by Associate Professor Wen Yin from Tokyo Metropolitan University has made significant strides using cutting-edge spectrographic technology. Their investigations utilize the Magellan Clay Telescope, one of the most advanced observational tools available, to capture the elusive signatures of […]
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Good Reads

Scientists just cracked the code to editing entire chromosomes flawlessly

Scientists just cracked the code to editing entire chromosomes flawlessly

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […]
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Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Worlwide

Scientists just cracked the code to editing entire chromosomes flawlessly

Scientists just cracked the code to editing entire chromosomes flawlessly

A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […]
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Disordered Interfacial Water Boosts Electrochemical C–C Coupling

In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […]
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Leveraging Next-Generation Tsunami Early Warning Systems to Save Lives – State of the Planet

Damage from the March 2011 tsunami in downtown Ofunato, Japan. Photo: U.S. Navy When an enormous 8.8 magnitude earthquake struck near Russia’s Kamchatka Peninsula, the impact reached far beyond its epicenter. In the passing hours, tsunami alerts were issued by several nations with coastlines along the Pacific Ocean’s Ring of Fire, prompting evacuations and escalating […]
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