Biology New Research Suggests Punitive Laws on Substance Use During Pregnancy Could In recent years, the United States has witnessed a growing wave of legislative efforts aimed at addressing substance use among pregnant and postpartum individuals. Against this backdrop, a groundbreaking study conducted by researchers at Columbia University’s Mailman School of Public Health offers an in-depth examination of how different state legal frameworks impact maternal health outcomes. […] Written by Bioengineer August 20, 2025August 20, 2025 Saving Bookmark this article Bookmarked
Biology Origin of chromosome 12 trisomy surge in human induced pluripotent stem cells Trisomy 12 is the most common whole-chromosome abnormality in human pluripotent stem cells. Conventionally, this acquired aneuploidy is ascribed to a rare single-cell event followed by selective growth advantage. Instead, we show that trisomy 12 emerges simultaneously in a very high percentage of cells in critical transition passages. Mis-segregation and incorporation of chromosome 12 into […] Written by Admin August 18, 2025August 18, 2025 Saving Bookmark this article Bookmarked
Biology Mpox Virus Impact in SIVmac239-Infected Macaques In the ever-evolving landscape of infectious diseases, the intersection of complex viral infections and immune-compromised hosts represents an urgent frontier in biomedical research. A groundbreaking study recently published in Nature Communications has provided unprecedented insights into how Mpox virus (formerly known as monkeypox virus) orchestrates multifaceted pathogenic mechanisms within immunodeficient hosts, specifically focusing on SIVmac239-infected […] Written by Bioengineer August 17, 2025August 17, 2025 Saving Bookmark this article Bookmarked
Biology Intraflagellar transport selectivity occurs within the proximal portion of the trypanosome flagellum Intraflagellar transport (IFT) trains move bidirectionally along the doublet microtubules (DMTs) of the axoneme within the flagellum. In Trypanosoma brucei, IFT trains predominantly associate with four of the nine DMTs. Using high-resolution microscopy, we reveal how this selective association is put in place. IFT proteins form a ring surrounding the 9 DMTs above the transition […] Written by Admin August 15, 2025August 15, 2025 Saving Bookmark this article Bookmarked
Biology Sarcocystis halieti DNA Found in Birds Across Europe In a groundbreaking study that reshapes our understanding of avian parasitology, researchers have successfully detected the DNA of Sarcocystis halieti—a parasitic protozoan—in the bloodstreams of several bird species across Europe. This finding not only illuminates the complex interactions between parasites and avian hosts but also raises intriguing questions about ecological dynamics, host specificity, and the […] Written by Bioengineer August 13, 2025August 13, 2025 Saving Bookmark this article Bookmarked
Biology Context is everything: The role of polo-like kinase I during C. elegans oocyte meiosis Meiotic chromosome segregation in oocytes often relies on meiosis-specific modifications of mitotic molecular mechanisms to respond to the unique challenges of this asymmetric division. In this issue, Narula and Wignall (https://doi.org/10.1083/jcb.202503080) demonstrate how the conserved polo-like kinase in Caenorhabditiselegans, PLK-1, has been repurposed in unexpected ways to ensure accurate meiotic chromosome segregation during oogenesis. Written by Admin August 11, 2025August 11, 2025 Saving Bookmark this article Bookmarked
Biology Al–Salen Catalyst Powers Enantioselective Photocyclization In a groundbreaking leap for synthetic chemistry, a team of scientists has unveiled a novel strategy harnessing energy transfer to achieve enantioselective photocyclization mediated by an aluminum-salen (Al–salen) catalyst. This pioneering work, recently published in Nature Chemistry, represents a paradigm shift in the way chemists can manipulate light-induced reactions with exquisite control over stereochemistry, heralding […] Written by Bioengineer August 9, 2025August 9, 2025 Saving Bookmark this article Bookmarked
Biology SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Biology Disordered Interfacial Water Boosts Electrochemical C–C Coupling In the relentless pursuit to combat climate change, the electrochemical conversion of carbon dioxide (CO₂) and carbon monoxide (CO) into value-added, energy-rich multi-carbon products has emerged as a beacon of hope. These processes promise not only to mitigate greenhouse gas emissions but also to create sustainable fuel alternatives that could revolutionize the energy landscape. However, […] Written by Bioengineer August 6, 2025August 6, 2025 Saving Bookmark this article Bookmarked
Biology Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube In this issue, Kim et al. (https://doi.org/10.1083/jcb.202409078) report that the scaffold protein Arc acts through Crumbs to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Drosophila salivary gland. This restriction is needed for a long, thin tube to form. Written by Admin August 4, 2025August 4, 2025 Saving Bookmark this article Bookmarked
Can Mayor Mamdani Turn Climate Action Into an Affordability Win for NYC? – State of the Planet Below-average temperatures and gusty winds did not deter tens of thousands of people from gathering in lower Manhattan last week to witness Zohran Mamdani take an oath to become New York City’s next mayor. Mayor Zohran Mamdani. Credit: Karamccurdy via Wikimedia Commons “Beginning today, we will govern expansively and audaciously,” Mamdani said during his inauguration speech. “We may not always succeed, but never will we be accused of lacking […] Written by Guest January 11, 2026January 11, 2026 Saving Bookmark this article Bookmarked
The biggest biotech funding rounds in December 2025 The companies Kymera Therapeutics, Immunovant, and Dyne Therapeutics bagged the biggest biotech funding rounds overall in December 2025 across private and public funding types. In this article, we break down last month’s private and public fundraising activity, looking at the largest rounds in more detail. Private biotech funding rounds in December 2025 First, let’s take […] Written by Willow Shah-Neville January 10, 2026January 10, 2026 Saving Bookmark this article Bookmarked
Can Mayor Mamdani Turn Climate Action Into an Affordability Win for NYC? – State of the Planet Below-average temperatures and gusty winds did not deter tens of thousands of people from gathering in lower Manhattan last week to witness Zohran Mamdani take an oath to become New York City’s next mayor. Mayor Zohran Mamdani. Credit: Karamccurdy via Wikimedia Commons “Beginning today, we will govern expansively and audaciously,” Mamdani said during his inauguration speech. “We may not always succeed, but never will we be accused of lacking […] Written by Guest January 11, 2026January 11, 2026 Saving Bookmark this article Bookmarked
The biggest biotech funding rounds in December 2025 The companies Kymera Therapeutics, Immunovant, and Dyne Therapeutics bagged the biggest biotech funding rounds overall in December 2025 across private and public funding types. In this article, we break down last month’s private and public fundraising activity, looking at the largest rounds in more detail. Private biotech funding rounds in December 2025 First, let’s take […] Written by Willow Shah-Neville January 10, 2026January 10, 2026 Saving Bookmark this article Bookmarked
The 4x rule: Why some people’s DNA is more unstable than others A large scale genetic analysis of more than 900,000 people has revealed that specific regions of DNA become increasingly unstable over time. These regions are made up of very short sequences that repeat again and again, and the study shows that they tend to grow longer as people age. Researchers also found that common inherited […] Written by Admin January 10, 2026January 10, 2026 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked
