Biology

  1. Biology

TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling

Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging.
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  1. Biology

Unraveling Their Role in Driving Brain Cancer

A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […]
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  1. Biology

ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13

Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational levels. In this study, we employed the CRISPR/Cas9-based screening of a ubiquitin ligase library to identify regulators of human peroxisomes. We discovered that ZBTB17 (MIZ1) […]
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  1. Biology

PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways

Arsenic effectively treats acute promyelocytic leukemia by inducing SUMO and ubiquitin-dependent degradation of the promyelocytic leukemia (PML)–retinoic acid receptor alpha oncogenic fusion protein. However, some patients relapse with arsenic-resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance, PML−/− cells were reconstituted with YFP fusions of wild-type PML-V and […]
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  1. Biology

Manufacturing Firms React to Randomized Energy Audits

In the quest to improve energy efficiency within manufacturing sectors of developing economies, researchers have increasingly turned to energy audits as a potential lever for change. These audits, designed to offer firms tailored insights into their energy usage and opportunities for cost reductions, represent one of the pivotal interventions aiming to balance environmental goals with […]
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  1. Biology

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

Intracellular transport among organellar compartments occurs in two general ways: by membrane-bound carriers and membrane contacts. Specific circumstances that involve the coordination of these two modes of transport remain to be defined. By studying coat protein I (COPI) transport, we find that phosphatidylcholine with short acyl chains (sPC) is delivered through membrane contact from the […]
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  1. Biology

Key Genes Linked to Parkinson’s Disease Discovered Using CRISPR

A recent groundbreaking study conducted by researchers at Northwestern Medicine has unveiled new insights into the complex interplay of genetics responsible for the risk of developing Parkinson’s disease (PD). The study, utilizing advanced CRISPR interference technology, meticulously scanned the entirety of the human genome, unveiling an unrecognized panel of genes pivotal to the disease’s pathogenesis. […]
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ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates

Protein aggregates are degraded by both the autophagy–lysosomal and the ubiquitin–proteasome pathways. Macroautophagy and microautophagy, two forms of the autophagy–lysosomal pathway, are widely conserved across eukaryotes. While macroautophagy has been extensively studied in the context of degradation of protein aggregates, microautophagy remains less explored. Here, we identify the UBAP1-containing ESCRT-I complex and PTPN23 as new […]
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  1. Biology

Dr. Romina Mizrahi Explores the Role of

In a significant advancement in the field of psychiatric research, Dr. Romina Mizrahi, a prominent figure at McGill University and the Douglas Research Center in Canada, is advocating for the integration of molecular-level analyses in understanding mental health disorders. Her work emphasizes the vital role of positron emission tomography (PET) in psychiatric medicine, aiming to […]
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