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  1. Biology

Securin regulates the spatiotemporal dynamics of separase

Separase regulates multiple aspects of the metaphase-to-anaphase transition. Separase cleaves cohesin to allow chromosome segregation and localizes to vesicles to promote exocytosis. The anaphase-promoting complex/cyclosome (APC/C) activates separase by ubiquitinating its inhibitory chaperone, securin, triggering its degradation. How this pathway controls the exocytic function of separase is unknown. During meiosis I, securin is degraded over […]
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  1. Environmental Science

What Role Can Climate Change Play in the Courtroom? – State of the Planet

Columbia’s Sabin Center for Climate Change Law focuses on four program areas: cross-cutting issues and initiatives, energy law, environmental and land use law, and international and foreign law. As the number of legal efforts involving each of these categories continues to grow, the center has positioned itself as a resource hub for tracking and analyzing […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

New model can help understand coexistence in nature

Different species of seabirds can coexist on small, isolated islands despite eating the same kind of fish. A researcher at Uppsala University has been involved in developing a mathematical model that can be used to better understand how this ecosystem works. “Our model shows that coexistence occurs naturally when species differ in their ability to […]
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Six bispecific antibody companies you should know about
  1. Biotechnology

Six bispecific antibody companies you should know about

Bispecific antibodies seem to be all the rage at the minute. Their ability to deliver targeted therapeutics to patients with a two-in-one approach by simultaneously binding to two different antigens or epitopes makes them an extremely attractive proposition to drug developers. This can be seen in the fact that there have been multiple big buyouts […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Scientists recreate mouse from gene older than animal life

Published in Nature Communications, an international team of researchers has achieved an unprecedented milestone: the creation of mouse stem cells capable of generating a fully developed mouse using genetic tools from a unicellular organism, with which we share a common ancestor that predates animals. This breakthrough reshapes our understanding of the genetic origins of stem […]
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  1. Pharmaceuticals and Drug Development

VU Researchers Publish Study on the Mechanism of CRISPR-Cas “Protein Scissors” in Molecular Cell

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, also known as DNA or gene ‘scissors’, which have revolutionized the field of genome editing, enabling scientists to […]
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  1. Biology

Visualizing ER-phagy and ER architecture in vivo

ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how ER-phagy and the ER network vary across cell subtypes, tissues, and organs. Furthermore, the pathophysiological relevance of ER-phagy remains poorly elucidated. Addressing these questions requires developing quantifiable methods to visualize ER-phagy and ER architecture in […]
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  1. Environmental Science

Workers and the just transition

Some takes the form of an anti-environmental backlash, instigated or colonised by conservative and far-right forces. While posing as allies of “working families”, they denigrate the most fundamental of workers’ needs: for a habitable planet.  Some takes a progressive form, the classic case being the gilets jaunes in France. When Emmanuel Macron’s government hiked “green […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Biodiversity in the city: Designing urban spaces for humans and animals

Animals and plants also live and thrive on public squares. This creates opportunities for greater biodiversity and well-being for the human population. Researchers at the Technical University of Munich (TUM) have studied at 103 locations in Munich how various factors affect flora and fauna. They advocate a close examination of local conditions and a more […]
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  1. Biology

Preserve or destroy: Orphan protein proteostasis and the heat shock response

Most eukaryotic genes encode polypeptides that are either obligate members of hetero-stoichiometric complexes or clients of organelle-targeting pathways. Proteins in these classes can be released from the ribosome as “orphans”—newly synthesized proteins not associated with their stoichiometric binding partner(s) and/or not targeted to their destination organelle. Here we integrate recent findings suggesting that although cells […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Biologists reveal the genetic ‘switch’ behind parrot color diversity

From the Carnival in Rio de Janeiro to the shoulders of pirates: parrots are synonymous with colour for people across the world. In a new study published in the journal Science, scientists from The University of Hong Kong, together with an international team led by scientists from BIOPOLIS-CIBIO (Portugal) uncover for the first time a […]
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  1. Environmental Science

Bridging Environmental Justice with Sustainable Energy – State of the Planet

Jada Johnson During her childhood in Atlanta, Georgia, Jada Johnson fell in love with nature. She’d spend countless hours exploring the outdoors with her siblings near the pond and forested areas by her home. But growing up in a predominantly Black and Brown community, she also witnessed environmental injustices firsthand, though she did not have […]
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Good Reads

VU Researchers Publish Study on the Mechanism of CRISPR-Cas “Protein Scissors” in Molecular Cell

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, also known as DNA or gene ‘scissors’, which have revolutionized the field of genome editing, enabling scientists to […]
Written by

Visualizing ER-phagy and ER architecture in vivo

ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how ER-phagy and the ER network vary across cell subtypes, tissues, and organs. Furthermore, the pathophysiological relevance of ER-phagy remains poorly elucidated. Addressing these questions requires developing quantifiable methods to visualize ER-phagy and ER architecture in […]
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Worlwide

VU Researchers Publish Study on the Mechanism of CRISPR-Cas “Protein Scissors” in Molecular Cell

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins today are Cas9 and Cas12, also known as DNA or gene ‘scissors’, which have revolutionized the field of genome editing, enabling scientists to […]
Written by

Visualizing ER-phagy and ER architecture in vivo

ER-phagy is an evolutionarily conserved mechanism crucial for maintaining cellular homeostasis. However, significant gaps persist in our understanding of how ER-phagy and the ER network vary across cell subtypes, tissues, and organs. Furthermore, the pathophysiological relevance of ER-phagy remains poorly elucidated. Addressing these questions requires developing quantifiable methods to visualize ER-phagy and ER architecture in […]
Written by

Workers and the just transition

Some takes the form of an anti-environmental backlash, instigated or colonised by conservative and far-right forces. While posing as allies of “working families”, they denigrate the most fundamental of workers’ needs: for a habitable planet.  Some takes a progressive form, the classic case being the gilets jaunes in France. When Emmanuel Macron’s government hiked “green […]
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