Life Sciences One gene defines the many patterns of snake skin In many animals, skin colouration and its patterns play a crucial role in camouflage, communication, or thermoregulation. In the corn snake, some morphs display red, yellow, or pink blotches, and their dorsal spots can merge or turn into stripes. But which genetic and cellular mechanisms determine these colourful patterns? A team from the University of […] Written by Admin April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked Pharmaceuticals and Drug Development Aldeyra Therapeutics Receives Complete Response Letter from the U.S. Food and Drug Administration for the Reproxalap New Drug Application for the Treatment of Signs and Symptoms of Dry Eye Disease LEXINGTON, Mass.–(BUSINESS WIRE)–Apr. 3, 2025– Aldeyra Therapeutics, Inc. (Nasdaq: ALDX) (Aldeyra), a biotechnology company devoted to discovering and developing innovative therapies designed to treat immune-mediated and metabolic diseases, today… Written by Admin April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked Biology TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging. Written by Admin April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked Environmental Science Exploring Sustainable Development in Rwanda and Bangladesh – State of the Planet This past March, two separate groups of students from the Office of Undergraduate Programs at the Columbia Climate School traveled to Rwanda and Bangladesh as part of their coursework in sustainable development. Their trips focused on exploring what sustainability means in the context of sub-Saharan Africa and on a tectonically active delta, respectively. Rwandan children […] Written by Guest April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked Life Sciences Floristic Diversity of Zygophyllum album Communities… Zygophyllum album L. (Zygophyllaceae) is a species of arid and hyperarid zones that has been the subject of many biochemical, pharmaceutical, and medicinal studies, but this species is largely unknown ecologically. This work aims to study the diversity and describe the characteristics of the functional traits of plant species of Zygophyllum album communities associated with […] Written by Souddi, Mohammed April 23, 2025April 23, 2025 Saving Bookmark this article Bookmarked Life Sciences The eukaryotic cell emerged as an evolutionary algorithmic phase transition An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant increase in complexity in the history of life’s evolution on Earth: the origin of the eukaryotic cell. While the endosymbiotic theory is widely accepted, the billions of years […] Written by Admin April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked Biology Unraveling Their Role in Driving Brain Cancer A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […] Written by Bioengineer April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked Environmental Science Carbon capture, or political capture? Greenpeace UK’s policy director Doug Parr said the investment would “extend the life of planet-heating oil and gas production”. Does this technology hold up to scrutiny, and what role, if any, should it play in decarbonisation? The UK government’s projects are based around CCUS, which involves usage of captured carbon, as opposed to just carbon […] Written by brendan April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked Biotechnology Whey Waste Finds New Life as Protein Paris-based start-up Standing Ovation’s patented process converts the serums supplied by Bel into functional casein proteins. The approach offers a sustainable alternative to conventional dairy supply chains. Bel hopes that, in addition to reducing waste and creating an additional valorisation stream, it will also promote a circular economy within the industry. “Thanks to this process, […] Written by Uta Mommert April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked Life Sciences In silico Structural and Functional Characterization of an… Actinoalloteichus hoggarensis is a rare bacterial species that was isolated from the Algerian Saharan desert and is known for producing biologically active compounds. Despite its potential, little is understood about the enzymes it produces, including endoglucanases. These cellulase enzymes break down cellulose, the primary structural component of plant cell walls that provides strength and rigidity. […] Written by Bakli, Mahfoud April 21, 2025April 21, 2025 Saving Bookmark this article Bookmarked Life Sciences Disrupting ‘communication’ with plants could limit soybean cyst nematode infections Targeting a newly discovered vulnerability in the signals that cyst nematodes use to infect plant roots could be a powerful method for reducing the damage the parasitic worms cause in crops such as soybeans, according to a study co-authored by an Iowa State University professor. Researchers identified a single protein in cyst nematodes that triggers […] Written by Admin April 20, 2025April 20, 2025 Saving Bookmark this article Bookmarked Biology ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13 Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational levels. In this study, we employed the CRISPR/Cas9-based screening of a ubiquitin ligase library to identify regulators of human peroxisomes. We discovered that ZBTB17 (MIZ1) […] Written by Admin April 20, 2025April 20, 2025 Saving Bookmark this article Bookmarked
Life Sciences One gene defines the many patterns of snake skin In many animals, skin colouration and its patterns play a crucial role in camouflage, communication, or thermoregulation. In the corn snake, some morphs display red, yellow, or pink blotches, and their dorsal spots can merge or turn into stripes. But which genetic and cellular mechanisms determine these colourful patterns? A team from the University of […] Written by Admin April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Aldeyra Therapeutics Receives Complete Response Letter from the U.S. Food and Drug Administration for the Reproxalap New Drug Application for the Treatment of Signs and Symptoms of Dry Eye Disease LEXINGTON, Mass.–(BUSINESS WIRE)–Apr. 3, 2025– Aldeyra Therapeutics, Inc. (Nasdaq: ALDX) (Aldeyra), a biotechnology company devoted to discovering and developing innovative therapies designed to treat immune-mediated and metabolic diseases, today… Written by Admin April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked
Biology TMBIM-2 links neuronal mitochondrial stress to systemic adaptation via calcium signaling Mitochondrial function is critical for neuronal activity and systemic metabolic adaptation. In this issue, Li et al. (https://doi.org/10.1083/jcb.202408050) identify TMBIM-2 as a key regulator of calcium dynamics, coordinating the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt), pathogen-induced aversive learning, and aging. Written by Admin April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked
Environmental Science Exploring Sustainable Development in Rwanda and Bangladesh – State of the Planet This past March, two separate groups of students from the Office of Undergraduate Programs at the Columbia Climate School traveled to Rwanda and Bangladesh as part of their coursework in sustainable development. Their trips focused on exploring what sustainability means in the context of sub-Saharan Africa and on a tectonically active delta, respectively. Rwandan children […] Written by Guest April 24, 2025April 24, 2025 Saving Bookmark this article Bookmarked
Life Sciences Floristic Diversity of Zygophyllum album Communities… Zygophyllum album L. (Zygophyllaceae) is a species of arid and hyperarid zones that has been the subject of many biochemical, pharmaceutical, and medicinal studies, but this species is largely unknown ecologically. This work aims to study the diversity and describe the characteristics of the functional traits of plant species of Zygophyllum album communities associated with […] Written by Souddi, Mohammed April 23, 2025April 23, 2025 Saving Bookmark this article Bookmarked
Life Sciences The eukaryotic cell emerged as an evolutionary algorithmic phase transition An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant increase in complexity in the history of life’s evolution on Earth: the origin of the eukaryotic cell. While the endosymbiotic theory is widely accepted, the billions of years […] Written by Admin April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Biology Unraveling Their Role in Driving Brain Cancer A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […] Written by Bioengineer April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Environmental Science Carbon capture, or political capture? Greenpeace UK’s policy director Doug Parr said the investment would “extend the life of planet-heating oil and gas production”. Does this technology hold up to scrutiny, and what role, if any, should it play in decarbonisation? The UK government’s projects are based around CCUS, which involves usage of captured carbon, as opposed to just carbon […] Written by brendan April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Biotechnology Whey Waste Finds New Life as Protein Paris-based start-up Standing Ovation’s patented process converts the serums supplied by Bel into functional casein proteins. The approach offers a sustainable alternative to conventional dairy supply chains. Bel hopes that, in addition to reducing waste and creating an additional valorisation stream, it will also promote a circular economy within the industry. “Thanks to this process, […] Written by Uta Mommert April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Life Sciences In silico Structural and Functional Characterization of an… Actinoalloteichus hoggarensis is a rare bacterial species that was isolated from the Algerian Saharan desert and is known for producing biologically active compounds. Despite its potential, little is understood about the enzymes it produces, including endoglucanases. These cellulase enzymes break down cellulose, the primary structural component of plant cell walls that provides strength and rigidity. […] Written by Bakli, Mahfoud April 21, 2025April 21, 2025 Saving Bookmark this article Bookmarked
Life Sciences Disrupting ‘communication’ with plants could limit soybean cyst nematode infections Targeting a newly discovered vulnerability in the signals that cyst nematodes use to infect plant roots could be a powerful method for reducing the damage the parasitic worms cause in crops such as soybeans, according to a study co-authored by an Iowa State University professor. Researchers identified a single protein in cyst nematodes that triggers […] Written by Admin April 20, 2025April 20, 2025 Saving Bookmark this article Bookmarked
Biology ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13 Peroxisomes are integral metabolic organelles involved in both catabolic and anabolic processes in humans, with defects linked to diseases. The functions of peroxisomes are regulated at transcriptional, translational, and posttranslational levels. In this study, we employed the CRISPR/Cas9-based screening of a ubiquitin ligase library to identify regulators of human peroxisomes. We discovered that ZBTB17 (MIZ1) […] Written by Admin April 20, 2025April 20, 2025 Saving Bookmark this article Bookmarked
The eukaryotic cell emerged as an evolutionary algorithmic phase transition An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant increase in complexity in the history of life’s evolution on Earth: the origin of the eukaryotic cell. While the endosymbiotic theory is widely accepted, the billions of years […] Written by Admin April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Unraveling Their Role in Driving Brain Cancer A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […] Written by Bioengineer April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
The eukaryotic cell emerged as an evolutionary algorithmic phase transition An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant increase in complexity in the history of life’s evolution on Earth: the origin of the eukaryotic cell. While the endosymbiotic theory is widely accepted, the billions of years […] Written by Admin April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Unraveling Their Role in Driving Brain Cancer A groundbreaking study from Weill Cornell Medicine is reshaping our understanding of glioblastoma, one of the deadliest brain cancers, by revealing how the three-dimensional architecture of DNA within the nucleus influences tumor behavior. Published on April 3, 2025, in the journal Molecular Cell, this innovative research moves beyond the traditional focus on gene mutations to […] Written by Bioengineer April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Carbon capture, or political capture? Greenpeace UK’s policy director Doug Parr said the investment would “extend the life of planet-heating oil and gas production”. Does this technology hold up to scrutiny, and what role, if any, should it play in decarbonisation? The UK government’s projects are based around CCUS, which involves usage of captured carbon, as opposed to just carbon […] Written by brendan April 22, 2025April 22, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked