Life Sciences Conservation paradox: Invasive species are often threatened in their native range Non-native species introduced by humans are among the main causes of global species decline – they were partly responsible for 60 percent of the species that have become extinct worldwide in recent decades. In Central Europe, non-native mammals include species such as the Norway rat, the mouflon and the mink. Now a study led by […] Written by Admin December 7, 2024December 7, 2024 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1733558481.5b78c56 Written by Admin December 7, 2024December 7, 2024 Saving Bookmark this article Bookmarked
Biology Non-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation Tubulin polyglutamylation is a posttranslational modification that occurs primarily along the axoneme of cilia. Defective axoneme polyglutamylation impairs cilia function and has been correlated with ciliopathies, including Joubert Syndrome (JBTS). However, the precise mechanisms regulating proper axoneme polyglutamylation remain vague. Here, we show that cyclin-dependent kinase 6 (CDK6), but not its paralog CDK4, localizes to […] Written by Admin December 7, 2024December 7, 2024 Saving Bookmark this article Bookmarked
Environmental Science The truth behind Europe’s floods Media coverage has criticised government failures to adequately prepare and react to Valencia’s floods – from building in flood-prone areas, to the dismantling of the Valencian Emergency Unit, to the delayed disaster response. These critiques are right – but they miss the crux of the issue. When we pave over forests to expand our cities, drain coastal wetlands […] Written by Catherine Early December 7, 2024December 7, 2024 Saving Bookmark this article Bookmarked
Biotechnology Excipient Use in Biopharmaceuticals: Key Insights – ChemIntel360 Originally published at Get our excipient business reports at and our drug patent reports at https://chemintel360.com/product-category/drug-patent-reports/ The biopharmaceutical industry has witnessed significant advancements over the past few decades, with excipients playing a crucial role in the formulation and stability of therapeutic drugs. Excipients, often considered the unsung heroes of drug development, are essential components that […] Written by ChemIntel360 December 6, 2024December 6, 2024 Saving Bookmark this article Bookmarked
Life Sciences From one gene switch, many possible outcomes The University of Pennsylvania’s Aman Husbands, of the School of Arts & Sciences, uncovered surprising ways transcription factors, the genetic switches for genes, regulate plant development. Their findings reveal how subtle changes in a lipid-binding region called the START domain can dramatically alter gene regulation, paving the way for advancements in crop engineering, synthetic biology, […] Written by Admin December 6, 2024December 6, 2024 Saving Bookmark this article Bookmarked
Life Sciences Mammoth as key food source for ancient Americans Scientists have uncovered the first direct evidence that ancient Americans relied primarily on mammoth and other large animals for food. Their research sheds new light on both the rapid expansion of humans throughout the Americas and the extinction of large ice age mammals. The study, featured on the Dec. 4 cover of the journal Science […] Written by Admin December 5, 2024December 5, 2024 Saving Bookmark this article Bookmarked
Biology One step 4× and 12× 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures Super-resolution microscopy has become an indispensable tool across diverse research fields, offering unprecedented insights into biological architectures with nanometer scale resolution. Compared with traditional nanometer-scale imaging methods such as electron microscopy, super-resolution microscopy offers several advantages, including the simultaneous labeling of multiple target biomolecules with high specificity and simpler sample preparation, making it accessible to […] Written by Admin December 5, 2024December 5, 2024 Saving Bookmark this article Bookmarked
Environmental Science Four Value Propositions for Climate Action Under a New Presidential Administration – State of the Planet There’s no mincing words: The forthcoming transition of United States presidential administrations is sending shockwaves through the climate advocacy community. Many say that it highlights an almost definitive exponential increase in emissions. Carbon Brief suggests an additional 4 billion tons of emissions by 2030; the MIT technology review asserts this is an emissions trajectory we […] Written by Guest December 5, 2024December 5, 2024 Saving Bookmark this article Bookmarked
Life Sciences Backyard chickens are here to stay Chickens have been a mainstay in Australian backyards for generations. New research from the University of Adelaide reveals that owners see their chooks as a blend between pet and livestock as well as a trustworthy source of food. “Our research indicated that backyard chickens are seen as both companion animals and as a source of […] Written by Admin December 4, 2024December 4, 2024 Saving Bookmark this article Bookmarked
Biology KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT The histone locus body (HLB) is a membraneless organelle that determines the transcription of replication-dependent histones. However, the mechanisms underlying the appropriate formation of the HLB in the nucleus but not in the cytoplasm remain unknown. HLB formation is dependent on the scaffold protein NPAT. We identify KPNA3 as a specific importin that drives the […] Written by Admin December 3, 2024December 3, 2024 Saving Bookmark this article Bookmarked
Environmental Science Israeli bombings destroy lives – and nature These attacks, deemed war crimes by international NGOs, have also destroyed 1,900 hectares of farmland and rendered another 1,200 hectares abandoned. Lebanon has lost 47,000 olive trees, thousands of animals in livestock, and 1,200 hectares of forest. “Olive trees have always been targeted because they are deeply tied to the land and its people,” says […] Written by brendan December 3, 2024December 3, 2024 Saving Bookmark this article Bookmarked