Admin's articles Life Sciences Misha lived in zoos, but the elephant’s tooth enamel helps reconstruct wildlife migrations Teeth recovered from a beloved zoo elephant that died in 2008 are helping University of Utah geologists develop a method for tracking the movements of large herbivores across landscapes, even for animals now extinct, such as mastodons and mammoths. Outlined in recently published findings, the technique analyzes isotope ratios of the element strontium (Sr), which […] Written by Admin March 17, 2025March 17, 2025 Saving Bookmark this article Bookmarked Biology Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase Proteostasis involves degradation and recycling of proteins from organelles, membranes, and multiprotein complexes. These processes can depend on protein extraction and unfolding by the essential mechanoenzyme valosin-containing protein (VCP) and on ubiquitin chain remodeling by ubiquitin-specific proteases known as deubiquitinases (DUBs). How the activities of VCP and DUBs are coordinated is poorly understood. Here, we […] Written by Admin March 17, 2025March 17, 2025 Saving Bookmark this article Bookmarked Life Sciences Scientists discover how to reactivate cancer’s molecular ‘kill switch’ Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film. By selecting which scenes to keep and which to leave out, the editor can produce a drama, a comedy, or even a thriller — all from the same raw material. Similarly, cells […] Written by Admin March 16, 2025March 16, 2025 Saving Bookmark this article Bookmarked Life Sciences Social media can help track species as climate changes Social media can help scientists track animal species as they relocate in response to climate change, new research shows. The “range” inhabited by many species is shifting, and this is mostly tracked by formal monitoring schemes and surveys — but these methods may struggle to spot rapid changes, and sometimes overlook urban areas. The new […] Written by Admin March 15, 2025March 15, 2025 Saving Bookmark this article Bookmarked Life Sciences Researchers develop method to identify dormant cells that carry HIV Mount Sinai researchers have developed a method to uncover the hidden immune cells that harbor the human immunodeficiency virus (HIV), a discovery that brings medical experts one step closer to a cure for the infection affecting nearly 40 million people globally. The findings were published in Nature Communications on March 6. HIV is a virus […] Written by Admin March 14, 2025March 14, 2025 Saving Bookmark this article Bookmarked Biology Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers CIZ1 is part of the RNA-dependent supramolecular assemblies that form around the inactive X-chromosome (Xi) in female cells and smaller assemblies throughout the nucleus in both sexes. Here, we show that CIZ1 C-terminal anchor domain (AD) is elevated in human breast tumor transcriptomes, even at stage I. Elevation correlates with deprotection of chromatin and upregulation […] Written by Admin March 14, 2025March 14, 2025 Saving Bookmark this article Bookmarked Life Sciences US bird populations continue alarming decline The release of the 2025 U.S. State of the Birds report was announced today at the 90th annual North American Wildlife and Natural Resources Conference in Louisville, Kentucky. The report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with […] Written by Admin March 13, 2025March 13, 2025 Saving Bookmark this article Bookmarked Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1741855904.14cb967 Written by Admin March 13, 2025March 13, 2025 Saving Bookmark this article Bookmarked Life Sciences Want to preserve biodiversity? Go big Large, undisturbed forests are better for harboring biodiversity than fragmented landscapes, according to recent research. Ecologists agree that habitat loss and the fragmentation of forests reduces biodiversity in the remaining fragments. But ecologists don’t agree whether it’s better to focus on preserving many smaller, fragmented tracts of land or larger, continuous landscapes. The study comes […] Written by Admin March 12, 2025March 12, 2025 Saving Bookmark this article Bookmarked Life Sciences A 62-million-year-old skeleton sheds light on an enigmatic mammal For more than 140 years, Mixodectes pungens, a species of small mammal that inhabited western North America in the early Paleocene, was a mystery. What little was known about them had been mostly gleaned from analyzing fossilized teeth and jawbone fragments. But a new study of the most complete skeleton of the species known to […] Written by Admin March 11, 2025March 11, 2025 Saving Bookmark this article Bookmarked Life Sciences Nearly half of popular tropical plant group related to birds-of-paradise and bananas are threatened with extinction A new analysis from researchers at the Smithsonian’s National Museum of Natural History reveals that nearly half of the genus Heliconia, a group of tropical plants popular for their bright, beak-shaped flowers, are threatened with extinction. The findings, published today, March 7, in the journal Plants, People, Planet, reveal that many of these imperiled plants […] Written by Admin March 10, 2025March 10, 2025 Saving Bookmark this article Bookmarked Biology Vacuoles provide the source membrane for TORC1-containing signaling endosomes Organelle biogenesis is fundamental to eukaryotic cell biology. Yeast signaling endosomes were recently identified as a signaling platform for the evolutionarily conserved Target of Rapamycin Complex 1 (TORC1) kinase complex. Despite the importance of signaling endosomes for TORC1-mediated control of cellular metabolism, how this organelle is generated has been a mystery. Here, we developed a […] Written by Admin March 10, 2025March 10, 2025 Saving Bookmark this article Bookmarked Loading Load more
Life Sciences Misha lived in zoos, but the elephant’s tooth enamel helps reconstruct wildlife migrations Teeth recovered from a beloved zoo elephant that died in 2008 are helping University of Utah geologists develop a method for tracking the movements of large herbivores across landscapes, even for animals now extinct, such as mastodons and mammoths. Outlined in recently published findings, the technique analyzes isotope ratios of the element strontium (Sr), which […] Written by Admin March 17, 2025March 17, 2025 Saving Bookmark this article Bookmarked
Biology Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase Proteostasis involves degradation and recycling of proteins from organelles, membranes, and multiprotein complexes. These processes can depend on protein extraction and unfolding by the essential mechanoenzyme valosin-containing protein (VCP) and on ubiquitin chain remodeling by ubiquitin-specific proteases known as deubiquitinases (DUBs). How the activities of VCP and DUBs are coordinated is poorly understood. Here, we […] Written by Admin March 17, 2025March 17, 2025 Saving Bookmark this article Bookmarked
Life Sciences Scientists discover how to reactivate cancer’s molecular ‘kill switch’ Alternative RNA splicing is like a movie editor cutting and rearranging scenes from the same footage to create different versions of a film. By selecting which scenes to keep and which to leave out, the editor can produce a drama, a comedy, or even a thriller — all from the same raw material. Similarly, cells […] Written by Admin March 16, 2025March 16, 2025 Saving Bookmark this article Bookmarked
Life Sciences Social media can help track species as climate changes Social media can help scientists track animal species as they relocate in response to climate change, new research shows. The “range” inhabited by many species is shifting, and this is mostly tracked by formal monitoring schemes and surveys — but these methods may struggle to spot rapid changes, and sometimes overlook urban areas. The new […] Written by Admin March 15, 2025March 15, 2025 Saving Bookmark this article Bookmarked
Life Sciences Researchers develop method to identify dormant cells that carry HIV Mount Sinai researchers have developed a method to uncover the hidden immune cells that harbor the human immunodeficiency virus (HIV), a discovery that brings medical experts one step closer to a cure for the infection affecting nearly 40 million people globally. The findings were published in Nature Communications on March 6. HIV is a virus […] Written by Admin March 14, 2025March 14, 2025 Saving Bookmark this article Bookmarked
Biology Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers CIZ1 is part of the RNA-dependent supramolecular assemblies that form around the inactive X-chromosome (Xi) in female cells and smaller assemblies throughout the nucleus in both sexes. Here, we show that CIZ1 C-terminal anchor domain (AD) is elevated in human breast tumor transcriptomes, even at stage I. Elevation correlates with deprotection of chromatin and upregulation […] Written by Admin March 14, 2025March 14, 2025 Saving Bookmark this article Bookmarked
Life Sciences US bird populations continue alarming decline The release of the 2025 U.S. State of the Birds report was announced today at the 90th annual North American Wildlife and Natural Resources Conference in Louisville, Kentucky. The report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with […] Written by Admin March 13, 2025March 13, 2025 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1741855904.14cb967 Written by Admin March 13, 2025March 13, 2025 Saving Bookmark this article Bookmarked
Life Sciences Want to preserve biodiversity? Go big Large, undisturbed forests are better for harboring biodiversity than fragmented landscapes, according to recent research. Ecologists agree that habitat loss and the fragmentation of forests reduces biodiversity in the remaining fragments. But ecologists don’t agree whether it’s better to focus on preserving many smaller, fragmented tracts of land or larger, continuous landscapes. The study comes […] Written by Admin March 12, 2025March 12, 2025 Saving Bookmark this article Bookmarked
Life Sciences A 62-million-year-old skeleton sheds light on an enigmatic mammal For more than 140 years, Mixodectes pungens, a species of small mammal that inhabited western North America in the early Paleocene, was a mystery. What little was known about them had been mostly gleaned from analyzing fossilized teeth and jawbone fragments. But a new study of the most complete skeleton of the species known to […] Written by Admin March 11, 2025March 11, 2025 Saving Bookmark this article Bookmarked
Life Sciences Nearly half of popular tropical plant group related to birds-of-paradise and bananas are threatened with extinction A new analysis from researchers at the Smithsonian’s National Museum of Natural History reveals that nearly half of the genus Heliconia, a group of tropical plants popular for their bright, beak-shaped flowers, are threatened with extinction. The findings, published today, March 7, in the journal Plants, People, Planet, reveal that many of these imperiled plants […] Written by Admin March 10, 2025March 10, 2025 Saving Bookmark this article Bookmarked
Biology Vacuoles provide the source membrane for TORC1-containing signaling endosomes Organelle biogenesis is fundamental to eukaryotic cell biology. Yeast signaling endosomes were recently identified as a signaling platform for the evolutionarily conserved Target of Rapamycin Complex 1 (TORC1) kinase complex. Despite the importance of signaling endosomes for TORC1-mediated control of cellular metabolism, how this organelle is generated has been a mystery. Here, we developed a […] Written by Admin March 10, 2025March 10, 2025 Saving Bookmark this article Bookmarked