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Biotechnology Zydus' phase 3 liver disease win tees up filing to challenge Gilead and Ipsen Zydus Therapeutics has racked up a phase 2b/3 win in primary biliary cholangitis, clearing the path to a filing to establish the company as a challenger to Gilead, Intercept Pharmaceuticals and Ipsen. Written by Admin August 30, 2025August 30, 2025 Saving Bookmark this article Bookmarked
Life Sciences Scientists discover armored “goblin monster” in prehistoric Utah A newly discovered, raccoon-sized armored monstersaurian from the Grand Staircase-Escalante National Monument in Southern Utah, United States, reveals a surprising diversity of large lizards at the pinnacle of the age of dinosaurs. Named for the goblin prince from J.R.R. Tolkien’s “The Hobbit,” the new species Bolg amondol also illuminates the sometimes-murky path that life traveled […] Written by Admin August 30, 2025August 30, 2025 Saving Bookmark this article Bookmarked
Biology Submembrane liprin-α1 clusters spatially localize insulin granule fusion Insulin granule fusion in pancreatic β cells localizes to where they contact the ECM of the islet capillaries. The mechanism(s) underpinning localization are unclear. Using glucose or high K+ stimulation or the global uncaging of Ca2+, we show granule fusion consistently focused to the β cell–ECM interface, suggesting a specific localization mechanism. We tested for […] Written by Admin August 29, 2025August 29, 2025 Saving Bookmark this article Bookmarked
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Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
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