Biology EGFR Stops α-Synuclein Clumps via DNAJB1 In a groundbreaking advance in the battle against Parkinson’s disease, researchers have unveiled a novel molecular pathway through which the epidermal growth factor receptor (EGFR) acts to mitigate one of the disease’s most destructive features: the aggregation of α-synuclein proteins in neuronal cells. This discovery shines new light on the intricate molecular dance that governs […] Written by Bioengineer June 8, 2025June 8, 2025 Saving Bookmark this article Bookmarked
Environmental Science 'Hey Equinor, leave them kids alone' ‘Hey Equinor, leave them kids alone’ Channel News brendan 6th June 2025 Teaser Media Written by brendan June 8, 2025June 8, 2025 Saving Bookmark this article Bookmarked
Biotechnology Nanofiber Electronics with Octopus-Inspired 3D Suction In a groundbreaking advancement that could revolutionize wearable health technology and drug delivery systems, researchers have unveiled an innovative skin-adaptive nanofiber-based adhesive electronic device featuring biomimetic 3D suction cups inspired by octopuses. This cutting-edge development promises enhanced transdermal delivery by leveraging a novel approach that combines mechanical adhesion with ultraflexible electronics, ushering in a new […] Written by Bioengineer June 8, 2025June 8, 2025 Saving Bookmark this article Bookmarked
Life Sciences Extreme weather is wiping out amphibians—Here’s where it’s worst The fire salamander native to Europe is one of many species that depend on sufficient moisture. Credit: Daniel Rosengren/Frankfurt Zoological Society Habitat loss, diseases, pollution, and climate change are already massively affecting amphibians – frogs, salamanders, and the caecilians native to tropical regions. The new study from the Institute for Ecology, Evolution and Diversity shows […] Written by Admin June 7, 2025June 7, 2025 Saving Bookmark this article Bookmarked
Life Sciences Long shot science leads to revised age for land-animal ancestor In 1984, an amateur paleontologist in Scotland found a remarkable specimen: a nearly complete fossil of what looked to be a lizard or salamander. Rather small in size at 20 centimeters, it would turn out to be a crucial piece in the puzzle of animal evolution. This creature, called Westlothiana lizziae, is one of the […] Written by Admin June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Biology Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity Stereocilia are rod-like mechanosensory projections consisting of unidirectionally oriented actin filaments that extend into the inner ear hair cell cytoskeleton, forming dense rootlets. Taperin (TPRN) localizes to the narrowed-down base of stereocilia, where they pivot in response to sound and gravity. We show that TPRN–deficient mice have progressive deafness characterized by gradual asynchronous retraction and […] Written by Admin June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Environmental Science Advancing Equity Through Clean Energy Policy – State of the Planet Nicholas Britton’s passion for energy policy began at Dartmouth College, where he majored in environmental studies and helped support the campus’s energy transition. Through fieldwork and research, from New Hampshire to Southern Africa to Washington, D.C., Britton developed a focus on equitable energy access as a means to serve both environmental and social goals. Now […] Written by Guest June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Life Sciences Two plant species invent the same chemically complex and medically interesting substance The elucidation of the biosynthetic pathway of ipecacuanha alkaloids shows how two distantly related plant species could develop the same substance independently. Plants produce an enormous abundance of natural products. Many plant natural products are ancestry-specific and occur only in certain plant families, sometimes only in a single species. Interestingly, however, the same substances can […] Written by Admin June 5, 2025June 5, 2025 Saving Bookmark this article Bookmarked
Pharmaceuticals and Drug Development Access Denied Access Denied You don’t have permission to access ” on this server. Reference #18.1d6d3e17.1749114910.3a1bd1d Written by Admin June 5, 2025June 5, 2025 Saving Bookmark this article Bookmarked
Life Sciences DNA floating in the air tracks wildlife, viruses — even drugs Dublin is known as a city where you can enjoy a few pints of Guiness, get a warm welcome from the locals and hear lively traditional music drifting out of pubs and into the city air. But it’s not just music floating on the breeze. The air of Dublin also contains cannabis, poppy, even magic […] Written by Admin June 4, 2025June 4, 2025 Saving Bookmark this article Bookmarked
Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity Stereocilia are rod-like mechanosensory projections consisting of unidirectionally oriented actin filaments that extend into the inner ear hair cell cytoskeleton, forming dense rootlets. Taperin (TPRN) localizes to the narrowed-down base of stereocilia, where they pivot in response to sound and gravity. We show that TPRN–deficient mice have progressive deafness characterized by gradual asynchronous retraction and […] Written by Admin June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Advancing Equity Through Clean Energy Policy – State of the Planet Nicholas Britton’s passion for energy policy began at Dartmouth College, where he majored in environmental studies and helped support the campus’s energy transition. Through fieldwork and research, from New Hampshire to Southern Africa to Washington, D.C., Britton developed a focus on equitable energy access as a means to serve both environmental and social goals. Now […] Written by Guest June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity Stereocilia are rod-like mechanosensory projections consisting of unidirectionally oriented actin filaments that extend into the inner ear hair cell cytoskeleton, forming dense rootlets. Taperin (TPRN) localizes to the narrowed-down base of stereocilia, where they pivot in response to sound and gravity. We show that TPRN–deficient mice have progressive deafness characterized by gradual asynchronous retraction and […] Written by Admin June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Advancing Equity Through Clean Energy Policy – State of the Planet Nicholas Britton’s passion for energy policy began at Dartmouth College, where he majored in environmental studies and helped support the campus’s energy transition. Through fieldwork and research, from New Hampshire to Southern Africa to Washington, D.C., Britton developed a focus on equitable energy access as a means to serve both environmental and social goals. Now […] Written by Guest June 6, 2025June 6, 2025 Saving Bookmark this article Bookmarked
Two plant species invent the same chemically complex and medically interesting substance The elucidation of the biosynthetic pathway of ipecacuanha alkaloids shows how two distantly related plant species could develop the same substance independently. Plants produce an enormous abundance of natural products. Many plant natural products are ancestry-specific and occur only in certain plant families, sometimes only in a single species. Interestingly, however, the same substances can […] Written by Admin June 5, 2025June 5, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked