Pharmaceuticals and Drug Development New £30m Initiative to Address Global Threat by Accelerating the Pace of Antimicrobial Innovation Innovate UK, LifeArc, and Medicines Discovery Catapult (MDC) have joined forces to create PACE (Pathways to Antimicrobial Clinical Efficacy), a £30 million initiative supporting early-stage innovation against antimicrobial resistance (AMR) to save lives. PACE has today (19 October 2023) announced its first funding call with up to £10 million available to support innovators developing new […] Written by Elsevier Ltd, The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, United Kingdom August 10, 2025August 10, 2025 Saving Bookmark this article Bookmarked
Life Sciences Nature’s anti-aging hack? Jewel wasp larvae slow their biological clock Scientists have discovered that jewel wasps can slow down their biological rate of aging. A study of jewel wasps, known for their distinctive metallic colors, has shown that they can undergo a kind of natural ‘time-out’ as larvae before emerging into adulthood with this surprising advantage. The groundbreaking study by scientists at the University of […] Written by Admin August 10, 2025August 10, 2025 Saving Bookmark this article Bookmarked
Biology Al–Salen Catalyst Powers Enantioselective Photocyclization In a groundbreaking leap for synthetic chemistry, a team of scientists has unveiled a novel strategy harnessing energy transfer to achieve enantioselective photocyclization mediated by an aluminum-salen (Al–salen) catalyst. This pioneering work, recently published in Nature Chemistry, represents a paradigm shift in the way chemists can manipulate light-induced reactions with exquisite control over stereochemistry, heralding […] Written by Bioengineer August 9, 2025August 9, 2025 Saving Bookmark this article Bookmarked
Environmental Science Canada Pledges $15 Million for Climate Adaptation in Hindu Kush Himalayan Region – State of the Planet Early this year, Canada pledged CA$15 million toward climate adaptation projects in Nepal, Bhutan and Bangladesh. It has teamed up with the International Center for Integrated Mountain Development (ICIMOD), a Nepal-based NGO. This contribution is a clear instance of climate adaptation finance—that is, funding toward projects that will help reduce vulnerability to climate change. The […] Written by Guest August 9, 2025August 9, 2025 Saving Bookmark this article Bookmarked
Life Sciences New “evolution engine” creates super-proteins 100,000x faster In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious. Now, Scripps Research scientists have developed a synthetic biology platform that accelerates evolution itself — enabling researchers to evolve proteins with useful, new properties thousands of times faster than nature. The […] Written by Admin August 9, 2025August 9, 2025 Saving Bookmark this article Bookmarked
Biology SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Environmental Science Military diverting critical materials from renewables A huge amount of critical mineral mining is ‘not essential’ for the green transition, new analysis from the UK-based campaigning organisation Global Justice Now has found. The analysis has today been published in a new report, titled ‘Material realities: who needs critical minerals and at whose expense?’. Global Justice Now is demanding the UK government […] Written by brendan August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Life Sciences DNA from the deep reveals a hidden ocean “superhighway” A world-first study led by Museums Victoria Research Institute has revealed that beneath the cold, dark, pressurized world of the deep sea, marine life is far more globally connected than previously imagined. Published on July 23 in Nature, this landmark study maps the global distribution and evolutionary relationships of brittle stars (Ophiuroidea), the ancient, spiny animals […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Biotechnology HHS abandons mRNA vaccine research One vaccine expert called the move, which cancels some $500 million in messenger RNA research contracts, a “giant step backward for science.” Written by Delilah Alvarado August 7, 2025August 7, 2025 Saving Bookmark this article Bookmarked
Life Sciences Scientists just cracked the code to editing entire chromosomes flawlessly A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August 4, achieves multiple types of precise DNA manipulations […] Written by Admin August 7, 2025August 7, 2025 Saving Bookmark this article Bookmarked
SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Military diverting critical materials from renewables A huge amount of critical mineral mining is ‘not essential’ for the green transition, new analysis from the UK-based campaigning organisation Global Justice Now has found. The analysis has today been published in a new report, titled ‘Material realities: who needs critical minerals and at whose expense?’. Global Justice Now is demanding the UK government […] Written by brendan August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Military diverting critical materials from renewables A huge amount of critical mineral mining is ‘not essential’ for the green transition, new analysis from the UK-based campaigning organisation Global Justice Now has found. The analysis has today been published in a new report, titled ‘Material realities: who needs critical minerals and at whose expense?’. Global Justice Now is demanding the UK government […] Written by brendan August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
DNA from the deep reveals a hidden ocean “superhighway” A world-first study led by Museums Victoria Research Institute has revealed that beneath the cold, dark, pressurized world of the deep sea, marine life is far more globally connected than previously imagined. Published on July 23 in Nature, this landmark study maps the global distribution and evolutionary relationships of brittle stars (Ophiuroidea), the ancient, spiny animals […] Written by Admin August 8, 2025August 8, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked