Dewpoint Tx' current pipeline
  1. Biotechnology

Dewpoint Therapeutics cuts workforce, refocuses pipeline

Despite securing US$287m from 16 investors across three funding rounds—US$60m (Series A, 2019), US$77m (Series B, 2020), and US$150m (Series C, 2022)—the firm cited a high burn rate as the reason for scaling back. Dewpoint will now prioritise clinical development of its lead candidate, DPTx3186, a beta-catenin inhibitor targeting the WNT signalling pathway, in gastric […]
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  1. Pharmaceuticals and Drug Development

New £30m Initiative to Address Global Threat by Accelerating the Pace of Antimicrobial Innovation

Innovate UK, LifeArc, and Medicines Discovery Catapult (MDC) have joined forces to create PACE (Pathways to Antimicrobial Clinical Efficacy), a £30 million initiative supporting early-stage innovation against antimicrobial resistance (AMR) to save lives. PACE has today (19 October 2023) announced its first funding call with up to £10 million available to support innovators developing new […]
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Nature’s anti-aging hack? Jewel wasp larvae slow their biological clock
  1. Life Sciences

Nature’s anti-aging hack? Jewel wasp larvae slow their biological clock

Scientists have discovered that jewel wasps can slow down their biological rate of aging. A study of jewel wasps, known for their distinctive metallic colors, has shown that they can undergo a kind of natural ‘time-out’ as larvae before emerging into adulthood with this surprising advantage. The groundbreaking study by scientists at the University of […]
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  1. Biology

Al–Salen Catalyst Powers Enantioselective Photocyclization

In a groundbreaking leap for synthetic chemistry, a team of scientists has unveiled a novel strategy harnessing energy transfer to achieve enantioselective photocyclization mediated by an aluminum-salen (Al–salen) catalyst. This pioneering work, recently published in Nature Chemistry, represents a paradigm shift in the way chemists can manipulate light-induced reactions with exquisite control over stereochemistry, heralding […]
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  1. Environmental Science

Canada Pledges $15 Million for Climate Adaptation in Hindu Kush Himalayan Region – State of the Planet

Early this year, Canada pledged CA$15 million toward climate adaptation projects in Nepal, Bhutan and Bangladesh. It has teamed up with the International Center for Integrated Mountain Development (ICIMOD), a Nepal-based NGO. This contribution is a clear instance of climate adaptation finance—that is, funding toward projects that will help reduce vulnerability to climate change. The […]
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New “evolution engine” creates super-proteins 100,000x faster
  1. Life Sciences

New “evolution engine” creates super-proteins 100,000x faster

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious. Now, Scripps Research scientists have developed a synthetic biology platform that accelerates evolution itself — enabling researchers to evolve proteins with useful, new properties thousands of times faster than nature. The […]
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  1. Biology

SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity

The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […]
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  1. Environmental Science

Military diverting critical materials from renewables

A huge amount of critical mineral mining is ‘not essential’ for the green transition, new analysis from the UK-based campaigning organisation Global Justice Now has found.  The analysis has today been published in a new report, titled ‘Material realities: who needs critical minerals and at whose expense?’. Global Justice Now is demanding the UK government […]
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DNA from the deep reveals a hidden ocean “superhighway”
  1. Life Sciences

DNA from the deep reveals a hidden ocean “superhighway”

A world-first study led by Museums Victoria Research Institute has revealed that beneath the cold, dark, pressurized world of the deep sea, marine life is far more globally connected than previously imagined. Published on July 23 in Nature, this landmark study maps the global distribution and evolutionary relationships of brittle stars (Ophiuroidea), the ancient, spiny animals […]
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Good Reads

New “evolution engine” creates super-proteins 100,000x faster

New “evolution engine” creates super-proteins 100,000x faster

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious. Now, Scripps Research scientists have developed a synthetic biology platform that accelerates evolution itself — enabling researchers to evolve proteins with useful, new properties thousands of times faster than nature. The […]
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SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity

The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […]
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Worlwide

New “evolution engine” creates super-proteins 100,000x faster

New “evolution engine” creates super-proteins 100,000x faster

In medicine and biotechnology, the ability to evolve proteins with new or improved functions is crucial, but current methods are often slow and laborious. Now, Scripps Research scientists have developed a synthetic biology platform that accelerates evolution itself — enabling researchers to evolve proteins with useful, new properties thousands of times faster than nature. The […]
Written by

SOD1 is delivered to lysosomes via autophagy to maintain lysosomal function and integrity

The gene encoding superoxide dismutase 1 (SOD1) is often mutated in familial amyotrophic lateral sclerosis (ALS), affecting motor neurons. Compared with ALS-associated mutant SOD1, the function of WT SOD1 is less explored. We demonstrate that during starvation, WT and mutant SOD1 are transported into lysosomes. Genome-wide CRISPR interference (CRISPRi) screening identified autophagy-related proteins and the […]
Written by

Military diverting critical materials from renewables

A huge amount of critical mineral mining is ‘not essential’ for the green transition, new analysis from the UK-based campaigning organisation Global Justice Now has found.  The analysis has today been published in a new report, titled ‘Material realities: who needs critical minerals and at whose expense?’. Global Justice Now is demanding the UK government […]
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