Pharmaceuticals and Drug Development UK antibiotic subscription model key to supporting antibiotic investment For the world to meet the health challenge posed by increasing antimicrobial resistance (AMR), new ways must be found to overcome the market failure that holds back the development of new antibiotics. Critical to this is greater understanding of the factors needed to persuade investors to support research and development (R&D) efforts. The latest report […] Written by Elsevier Ltd, The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, United Kingdom June 23, 2025June 23, 2025 Saving Bookmark this article Bookmarked
Life Sciences Frozen in time: Transparent worms keep genes in sync for 20 million years Two species of worms have retained remarkably similar patterns in the way they switch their genes on and off despite having split from a common ancestor 20 million years ago, a new study finds. The findings appear in the June 19 issue of the journal Science. “It was just remarkable, with this evolutionary distance, that […] Written by Admin June 22, 2025June 22, 2025 Saving Bookmark this article Bookmarked
Biology ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway The Fanconi anemia (FA) DNA repair pathway is required for the repair of DNA interstrand cross-links (ICLs). ICLs are caused by genotoxins, such as chemotherapeutic agents or reactive aldehydes. Inappropriately repaired ICLs contribute to hematopoietic stem cell (HSC) failure and tumorigenesis. While endogenous acetaldehyde and formaldehyde are known to induce HSC failure and leukemia in […] Written by Admin June 22, 2025June 22, 2025 Saving Bookmark this article Bookmarked
Environmental Science After the ‘Last Generation’ Soul-searching Second, the idea that repression of the movement would act as a ‘backfiring tool’, stirring public sympathy proved overly optimistic. “If they lock us up, there will be an outcry,” some activists claimed. Repression and court cases did not trigger mass support. Instead, the crackdowns dampened the movement’s momentum. Third, the rise of the […] Written by brendan June 22, 2025June 22, 2025 Saving Bookmark this article Bookmarked
Life Sciences Monster salamander with powerful jaws unearthed in Tennessee fossil find A giant, strong-jawed salamander once tunneled through ancient Tennessee soil. And thanks to a fossil unearthed near East Tennessee State University, scientists now better understand how it helped shape Appalachian amphibian diversity. The giant plethodontid salamander now joins the remarkable roster of fossils from the Gray Fossil Site & Museum. The findings appeared in the […] Written by Admin June 21, 2025June 21, 2025 Saving Bookmark this article Bookmarked
Biotechnology AI Diagnoses Vocal Cord Paralysis Severity In a groundbreaking advancement at the crossroads of artificial intelligence and clinical otolaryngology, researchers have unveiled an innovative platform that automatically assesses the severity of unilateral vocal cord paralysis (UVCP) using state-of-the-art deep learning techniques. This pioneering research leverages Mel-spectrograms—a sophisticated audio representation technique—paired with convolutional neural networks (CNN) to dissect subtle vocal characteristics, offering […] Written by Bioengineer June 21, 2025June 21, 2025 Saving Bookmark this article Bookmarked
Life Sciences Defying Darwin: Scientists discover worms rewrote their DNA to survive on land In 1859, Darwin imagined evolution as a slow, gradual progress, with species accumulating small changes over time. But even he was surprised to find the fossil record offered no missing links: the intermediate forms which should have told this story step by step were simply not there. His explanation was as uncomfortable as it was […] Written by Admin June 20, 2025June 20, 2025 Saving Bookmark this article Bookmarked
Biology Rising Serum Uric Acid Levels in US Teens In a comprehensive analysis spanning two decades, researchers have uncovered that serum uric acid (UA) concentrations and the prevalence of hyperuricemia have exhibited remarkable stability among adolescents in the United States. This longitudinal insight, meticulously documented in a recent study published in Pediatric Research, challenges prior assumptions about the possible upward trajectory of serum UA […] Written by Bioengineer June 20, 2025June 20, 2025 Saving Bookmark this article Bookmarked
Environmental Science More and more people missing from official data – State of the Planet Experts are warning that millions of people around the world aren’t being counted in census data, leaving policy makers in the dark about the populations they govern. They say a “quiet crisis” is unfolding with census data not being published due to concerns about declining response rates and the accuracy of data. In a paper […] Written by Columbia Climate School June 20, 2025June 20, 2025 Saving Bookmark this article Bookmarked
Life Sciences Cluck once, and the river shakes: Inside the Amazon’s giant snake saga As a child, I was fascinated by reports and documentaries about field research and often wondered what it took to be there and what kind of knowledge was being produced. Later, as an ecologist, I felt the need for approaches that better connected scientific research with real-world contexts. I became especially interested in perspectives that […] Written by Admin June 19, 2025June 19, 2025 Saving Bookmark this article Bookmarked
AI Diagnoses Vocal Cord Paralysis Severity In a groundbreaking advancement at the crossroads of artificial intelligence and clinical otolaryngology, researchers have unveiled an innovative platform that automatically assesses the severity of unilateral vocal cord paralysis (UVCP) using state-of-the-art deep learning techniques. This pioneering research leverages Mel-spectrograms—a sophisticated audio representation technique—paired with convolutional neural networks (CNN) to dissect subtle vocal characteristics, offering […] Written by Bioengineer June 21, 2025June 21, 2025 Saving Bookmark this article Bookmarked
Defying Darwin: Scientists discover worms rewrote their DNA to survive on land In 1859, Darwin imagined evolution as a slow, gradual progress, with species accumulating small changes over time. But even he was surprised to find the fossil record offered no missing links: the intermediate forms which should have told this story step by step were simply not there. His explanation was as uncomfortable as it was […] Written by Admin June 20, 2025June 20, 2025 Saving Bookmark this article Bookmarked
AI Diagnoses Vocal Cord Paralysis Severity In a groundbreaking advancement at the crossroads of artificial intelligence and clinical otolaryngology, researchers have unveiled an innovative platform that automatically assesses the severity of unilateral vocal cord paralysis (UVCP) using state-of-the-art deep learning techniques. This pioneering research leverages Mel-spectrograms—a sophisticated audio representation technique—paired with convolutional neural networks (CNN) to dissect subtle vocal characteristics, offering […] Written by Bioengineer June 21, 2025June 21, 2025 Saving Bookmark this article Bookmarked
Defying Darwin: Scientists discover worms rewrote their DNA to survive on land In 1859, Darwin imagined evolution as a slow, gradual progress, with species accumulating small changes over time. But even he was surprised to find the fossil record offered no missing links: the intermediate forms which should have told this story step by step were simply not there. His explanation was as uncomfortable as it was […] Written by Admin June 20, 2025June 20, 2025 Saving Bookmark this article Bookmarked
Rising Serum Uric Acid Levels in US Teens In a comprehensive analysis spanning two decades, researchers have uncovered that serum uric acid (UA) concentrations and the prevalence of hyperuricemia have exhibited remarkable stability among adolescents in the United States. This longitudinal insight, meticulously documented in a recent study published in Pediatric Research, challenges prior assumptions about the possible upward trajectory of serum UA […] Written by Bioengineer June 20, 2025June 20, 2025 Saving Bookmark this article Bookmarked
Understanding PMDA Validation Rules v5.0 The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan has always led the charge in ensuring the safety and efficacy of drug development. Their latest update, the PMDA Validation Rules version 5.0, which took effect on April 1, 2024, marks another significant step in this mission. Let’s break down what these new rules mean and […] Written by Admin July 10, 2024July 10, 2024 Saving Bookmark this article Bookmarked
Enhance Your SEND Submissions! Join PointCross on May 29th, 2024, at 12 PM EST / 9 AM PST for a must-attend webinar: The Most Common Issues in Preparing SEND. Ideal for professionals in data submission and regulatory compliance, this webinar offers valuable insights from our seasoned experts. Why Attend? Why PointCross? With over 10 years of experience and more […] Written by Admin May 23, 2024May 23, 2024 Saving Bookmark this article Bookmarked