From cursed tomb fungus to cancer cure: Aspergillus flavus yields potent new drug
  1. Life Sciences

From cursed tomb fungus to cancer cure: Aspergillus flavus yields potent new drug

Penn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells. The result? A promising cancer-killing compound that rivals FDA-approved […]
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  1. Pharmaceuticals and Drug Development

UK antibiotic subscription model key to supporting antibiotic investment

For the world to meet the health challenge posed by increasing antimicrobial resistance (AMR), new ways must be found to overcome the market failure that holds back the development of new antibiotics.  Critical to this is greater understanding of the factors needed to persuade investors to support research and development (R&D) efforts. The latest report […]
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Frozen in time: Transparent worms keep genes in sync for 20 million years
  1. Life Sciences

Frozen in time: Transparent worms keep genes in sync for 20 million years

Two species of worms have retained remarkably similar patterns in the way they switch their genes on and off despite having split from a common ancestor 20 million years ago, a new study finds. The findings appear in the June 19 issue of the journal Science. “It was just remarkable, with this evolutionary distance, that […]
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  1. Biology

ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway

The Fanconi anemia (FA) DNA repair pathway is required for the repair of DNA interstrand cross-links (ICLs). ICLs are caused by genotoxins, such as chemotherapeutic agents or reactive aldehydes. Inappropriately repaired ICLs contribute to hematopoietic stem cell (HSC) failure and tumorigenesis. While endogenous acetaldehyde and formaldehyde are known to induce HSC failure and leukemia in […]
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  1. Environmental Science

After the ‘Last Generation’

Soul-searching Second, the idea that repression of the movement would act as a ‘backfiring tool’, stirring public sympathy proved overly optimistic. “If they lock us up, there will be an outcry,” some activists claimed. Repression and court cases did not trigger mass support. Instead, the crackdowns dampened the movement’s momentum. Third, the rise of the […]
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Monster salamander with powerful jaws unearthed in Tennessee fossil find
  1. Life Sciences

Monster salamander with powerful jaws unearthed in Tennessee fossil find

A giant, strong-jawed salamander once tunneled through ancient Tennessee soil. And thanks to a fossil unearthed near East Tennessee State University, scientists now better understand how it helped shape Appalachian amphibian diversity. The giant plethodontid salamander now joins the remarkable roster of fossils from the Gray Fossil Site & Museum. The findings appeared in the […]
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AI Diagnoses Vocal Cord Paralysis Severity
  1. Biotechnology

AI Diagnoses Vocal Cord Paralysis Severity

In a groundbreaking advancement at the crossroads of artificial intelligence and clinical otolaryngology, researchers have unveiled an innovative platform that automatically assesses the severity of unilateral vocal cord paralysis (UVCP) using state-of-the-art deep learning techniques. This pioneering research leverages Mel-spectrograms—a sophisticated audio representation technique—paired with convolutional neural networks (CNN) to dissect subtle vocal characteristics, offering […]
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Defying Darwin: Scientists discover worms rewrote their DNA to survive on land
  1. Life Sciences

Defying Darwin: Scientists discover worms rewrote their DNA to survive on land

In 1859, Darwin imagined evolution as a slow, gradual progress, with species accumulating small changes over time. But even he was surprised to find the fossil record offered no missing links: the intermediate forms which should have told this story step by step were simply not there. His explanation was as uncomfortable as it was […]
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  1. Biology

Rising Serum Uric Acid Levels in US Teens

In a comprehensive analysis spanning two decades, researchers have uncovered that serum uric acid (UA) concentrations and the prevalence of hyperuricemia have exhibited remarkable stability among adolescents in the United States. This longitudinal insight, meticulously documented in a recent study published in Pediatric Research, challenges prior assumptions about the possible upward trajectory of serum UA […]
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  1. Environmental Science

More and more people missing from official data – State of the Planet

Experts are warning that millions of people around the world aren’t being counted in census data, leaving policy makers in the dark about the populations they govern. They say a “quiet crisis” is unfolding with census data not being published due to concerns about declining response rates and the accuracy of data. In a paper […]
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Good Reads

Monster salamander with powerful jaws unearthed in Tennessee fossil find

Monster salamander with powerful jaws unearthed in Tennessee fossil find

A giant, strong-jawed salamander once tunneled through ancient Tennessee soil. And thanks to a fossil unearthed near East Tennessee State University, scientists now better understand how it helped shape Appalachian amphibian diversity. The giant plethodontid salamander now joins the remarkable roster of fossils from the Gray Fossil Site & Museum. The findings appeared in the […]
Written by
AI Diagnoses Vocal Cord Paralysis Severity

AI Diagnoses Vocal Cord Paralysis Severity

In a groundbreaking advancement at the crossroads of artificial intelligence and clinical otolaryngology, researchers have unveiled an innovative platform that automatically assesses the severity of unilateral vocal cord paralysis (UVCP) using state-of-the-art deep learning techniques. This pioneering research leverages Mel-spectrograms—a sophisticated audio representation technique—paired with convolutional neural networks (CNN) to dissect subtle vocal characteristics, offering […]
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Worlwide

Monster salamander with powerful jaws unearthed in Tennessee fossil find

Monster salamander with powerful jaws unearthed in Tennessee fossil find

A giant, strong-jawed salamander once tunneled through ancient Tennessee soil. And thanks to a fossil unearthed near East Tennessee State University, scientists now better understand how it helped shape Appalachian amphibian diversity. The giant plethodontid salamander now joins the remarkable roster of fossils from the Gray Fossil Site & Museum. The findings appeared in the […]
Written by
AI Diagnoses Vocal Cord Paralysis Severity

AI Diagnoses Vocal Cord Paralysis Severity

In a groundbreaking advancement at the crossroads of artificial intelligence and clinical otolaryngology, researchers have unveiled an innovative platform that automatically assesses the severity of unilateral vocal cord paralysis (UVCP) using state-of-the-art deep learning techniques. This pioneering research leverages Mel-spectrograms—a sophisticated audio representation technique—paired with convolutional neural networks (CNN) to dissect subtle vocal characteristics, offering […]
Written by
Defying Darwin: Scientists discover worms rewrote their DNA to survive on land

Defying Darwin: Scientists discover worms rewrote their DNA to survive on land

In 1859, Darwin imagined evolution as a slow, gradual progress, with species accumulating small changes over time. But even he was surprised to find the fossil record offered no missing links: the intermediate forms which should have told this story step by step were simply not there. His explanation was as uncomfortable as it was […]
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