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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

Positive Top-Line Results from Real-World Study in China Evaluating the Safety and Efficacy of DEXTENZA in Patients after Cataract Surgery

SHANGHAI, Oct. 31, 2023. AffaMed Therapeutics (“AffaMed”), a global biotechnology company dedicated to developing and commercializing transformative pharmaceutical, digital and surgical products that address critical unmet medical needs in ophthalmological, neurological and psychiatric disorders, announced positive top-line results from the Real-World Study conducted in the Boao Lecheng Pilot Zone in Hainan, China, to evaluate the […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

Positive Results Announced in Largest Pivotal Phase 3 Trial of a First-in-Class Oral Antibiotic Zoliflodacin to Treat Uncomplicated Gonorrhea

This is the first study to address a World Health Organization priority pathogen that has been sponsored and led by a non-profit organization. These positive preliminary findings offer hope for patients with this condition, particularly in the face of rising antibiotic resistance to current regimens. It also paves the way for a new […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

Moderna Announces First Participant Dosed in Phase 3 Study of mRNA-1083, a Combination Vaccine Against Influenza and COVID-19

mRNA-1083 is Moderna’s first respiratory combination vaccine candidate to enter a Phase 3 trial Phase 3 initiation follows data from a Phase 1/2 trial where mRNA-1083 showed strong immunogenicity against influenza and COVID-19, with an acceptable reactogenicity and safety profile, compared to licensed standalone vaccines Company has multiple programs in Phase 3 […]
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Selfies, sugar, and death: How tourists are endangering elephants
  1. Life Sciences

Selfies, sugar, and death: How tourists are endangering elephants

A study led by a scientist at the University of California San Diego offers new warnings on the dangers of human interactions with wildlife. Assistant Professor Shermin de Silva of the School of Biological Sciences studies endangered Asian elephants and has reported on their shrinking habitats, a downturn that has resulted in territorial conflicts between […]
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The five great forests that keep North America’s birds alive
  1. Life Sciences

The five great forests that keep North America’s birds alive

Every spring, the familiar songs of Wood Thrushes and warblers drift back into parks and neighborhoods across eastern North America. Few people realize that these birds spend most of their lives much farther south, relying on the lush and often remote forests of Central America to survive the rest of the year. A recent study […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

One gene defines the many patterns of snake skin

In many animals, skin colouration and its patterns play a crucial role in camouflage, communication, or thermoregulation. In the corn snake, some morphs display red, yellow, or pink blotches, and their dorsal spots can merge or turn into stripes. But which genetic and cellular mechanisms determine these colourful patterns? A team from the University of […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Genetic tracing at the Huanan Seafood market further supports COVID animal origins

A new international collaborative study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC). The […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Elephant turns a hose into a sophisticated showering tool

Tool use isn’t unique to humans. Chimpanzees use sticks as tools. Dolphins, crows, and elephants are known for their tool-use abilities, too. Now a report in the Cell Press journal Current Biology on November 8, 2024, highlights elephants’ remarkable skill in using a hose as a flexible shower head. As an unexpected bonus, researchers say […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Largest protein yet discovered builds algal toxins

While seeking to unravel how marine algae create their chemically complex toxins, scientists at UC San Diego’s Scripps Institution of Oceanography have discovered the largest protein yet identified in biology. Uncovering the biological machinery the algae evolved to make its intricate toxin also revealed previously unknown strategies for assembling chemicals, which could unlock the development […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Unlocking the genetic basis of animal behavior using fruit flies

Understanding how genes influence complex behaviors remains one of biology’s most fascinating challenges. Now, however, in a recent study, researchers from Japan compiled a comprehensive dataset documenting the behaviors of over 30,000 fruit flies across 105 genetically distinct strains. This valuable resource captures individual and group behaviors under various conditions, providing unparalleled insights into the […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Insect genome offers insights into rare biological conditions, agricultural biosecurity

Lice live their entire lives with a set of genes that in humans would indicate a late-stage degenerative disorder such as Parkinson’s or Alzheimer’s disease. How do lice tolerate this genome structure that in humans and many other animals would result in major neurodegenerative problems? “We’re a long way from connecting those dots,” said Stephen […]
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Dolphins may be getting Alzheimer’s from toxic ocean blooms
  1. Life Sciences

Dolphins may be getting Alzheimer’s from toxic ocean blooms

For many nature enthusiasts, few scenes are as distressing as finding a stranded whale or dolphin lying helpless on the beach. When these animals are still alive, marine biologists and volunteers rush to assist, shielding them from the sun and preventing their skin from drying out by pouring seawater over them or draping them with […]
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  1. Biology

Stu2 performs an essential kinetochore function independent of its microtubule polymerase activity

ch-TOG family proteins, including the budding yeast Stu2, are essential for spindle formation and chromosome segregation. Such functions depend on an array of activities ranging from microtubule nucleation, polymerization, and depolymerization to conferring tension sensitivity to kinetochores. This functional diversity makes it challenging to dissect these various functions and understand their relative importance. Here, we […]
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  1. Biology

Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

CIZ1 is part of the RNA-dependent supramolecular assemblies that form around the inactive X-chromosome (Xi) in female cells and smaller assemblies throughout the nucleus in both sexes. Here, we show that CIZ1 C-terminal anchor domain (AD) is elevated in human breast tumor transcriptomes, even at stage I. Elevation correlates with deprotection of chromatin and upregulation […]
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  1. Biology

The underrated impact of humidity

Governments, medical institutions and other bodies require accurate models on health-related matters in order to better organize their activities. Climate change has measurable impacts on society, including on human mortality. However, current models to assess the health impacts of climate change do not account for every environmental parameter, especially humidity, which could influence heat stress […]
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  1. Biology

A biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells

HaloTag technology represents a versatile tool for studying proteins. Fluorescent HaloTag ligands employed in sequential labeling led to the discovery of distinct protein variants for histones, cohesins, and MCM complexes. However, an efficient biochemical approach to separate these distinct protein variants to study their biological functions is missing. Principally, being a gap in technology, the […]
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  1. Biology

Tubulin isotypes contribute opposing properties to balance anaphase spindle morphogenesis

Faithful chromosome segregation requires proper function of the mitotic spindle, which is built from, and depends on, the coordinated regulation of many microtubules and the activities of molecular motors and MAPs. In addition, microtubules themselves are assembled from multiple variants, or isotypes of α- and β-tubulin, yet whether they mediate the activities of motors and […]
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  1. Biology

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and cytokinesis completion

In animal cells, cleavage furrow formation is controlled by localized activation of the GTPase RhoA at the equatorial membrane using cues transmitted from the spindle. Here, we explore the function of LIN-5, a well-studied protein known for its role in aster separation and spindle positioning in cleavage furrow formation. We show that the cortical pool […]
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