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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

Daré Bioscience Announces Additional Positive Data from Phase 2b RESPOND Study of Sildenafil Cream, 3.6% in Women and Proposed Endpoints and Patient Population for Phase 3 Program

Additional Analyses of Phase 2b Data Conducted in Population of Study Participants with Female Sexual Interest/Arousal Disorder (FSIAD), With Primary Complaint of Arousal Dysfunction Achieved Statistical Significance and Clinically Meaningful Improvement in Phase 2b Co-Primary Endpoint Assessing Arousal Sensation, and Statistical Significance in Items from Phase 2b Co-Primary Endpoint Scale Evaluating Concern Related […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

FDA Clears Application to Initiate Phase 1 Clinical Study of oral Immunotherapy for the Treatment of Rheumatoid Arthritis

ROCKVILLE, Md., Oct. 19, 2023. – Rise Therapeutics, a biotechnology company engaged in developing novel oral immunotherapeutics, today announced that the U.S. Food and Drug Administration (FDA) has accepted its investigational new drug (IND) application to proceed with a rheumatoid arthritis Phase 1 clinical trial for its program candidate, R-2487. This is Rise Therapeutics’ second […]
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Before plants or animals, fungi conquered Earth’s surface
  1. Life Sciences

Before plants or animals, fungi conquered Earth’s surface

After examining the evolutionary history of fungi, an international group of scientists has concluded that these organisms first appeared between 900 million and 1.4 billion years ago, far earlier than scientists had believed. This suggests that fungi were thriving on Earth hundreds of millions of years before plants began to grow. The results, published open […]
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Mammals didn't walk upright until late—here's what fossils reveal
  1. Life Sciences

Mammals didn’t walk upright until late—here’s what fossils reveal

For over a century, scientists have puzzled over a fundamental mystery in our evolutionary history: how did mammals go from sprawling like lizards to striding like cats and dogs? This transition — from a sprawled stance (like a lizard) to an upright (parasagittal) posture — marked a pivotal moment in mammal evolution. While the earliest […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Once-endangered Kirtland’s warblers show extensive signs of inbreeding in genome

The genome of a once-endangered songbird shows extensive signs of inbreeding, according to a new study by Penn State researchers. Because inbreeding can negatively impact survival and reproduction, the results could guide continuing conservation efforts for Kirtland’s warblers, whose populations still rely on extensive management. The new study, published Dec. 9 in the journalEvolutionary Applications, […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Conservation focusing on birds of a feather may have mixed results

Conservation strategies are turning back the doomsday clock in threatened Florida-Scrub Jays — but not without caveats, a new study published in Current Biology shows. In the early 2000s, conservationists proposed a plan to move isolated jays to a region comprising thousands of acres of restored habitat, home to a small community of 13 jays. […]
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Scientists just uncovered three ancient worlds frozen beneath Illinois for 300 million years
  1. Life Sciences

Scientists just uncovered three ancient worlds frozen beneath Illinois for 300 million years

More than 300 million years ago, during the Carboniferous Period, much of northern Illinois outside Chicago — including what is now the Mazon Creek (“muh-ZAHN”) fossil site — was alive with ancient creatures thriving in lush, tropical swamps, river deltas and shallow seas. Now, researchers at the University of Missouri’s College of Arts and Science […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Researchers develop method to identify dormant cells that carry HIV

Mount Sinai researchers have developed a method to uncover the hidden immune cells that harbor the human immunodeficiency virus (HIV), a discovery that brings medical experts one step closer to a cure for the infection affecting nearly 40 million people globally. The findings were published in Nature Communications on March 6. HIV is a virus […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Aligned peptide ‘noodles’ might allow lab-grown organic tissues

A staff of chemists and bioengineers at Rice College and the College of Houston have achieved a major milestone of their work to create a biomaterial that can be utilized to develop organic tissues outdoors the human physique. The event of a novel fabrication course of to create aligned nanofiber hydrogels might provide new potentialities […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Two plant species invent the same chemically complex and medically interesting substance

The elucidation of the biosynthetic pathway of ipecacuanha alkaloids shows how two distantly related plant species could develop the same substance independently. Plants produce an enormous abundance of natural products. Many plant natural products are ancestry-specific and occur only in certain plant families, sometimes only in a single species. Interestingly, however, the same substances can […]
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242-million-year-old mini predator changes lizard evolution
  1. Life Sciences

242-million-year-old mini predator changes lizard evolution

A recently analyzed fossil from Devon is giving scientists a rare look at what the earliest members of the lizard lineage may have looked like, and the findings come with several unexpected twists, according to researchers at the University of Bristol. The work was published in Nature. Today, lizards and their close relatives, including snakes […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Successful strategies for collaborative species conservation

How can the loss of species and habitats in agricultural landscapes be stopped? Up to now, measures have mostly been implemented by individual farms. In contrast, agri-environmental measures that are planned across farms at landscape level offer greater potential for creating suitable habitats for different species as a mosaic in the landscape. However, successful landscape […]
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Scientists reveal a hidden alarm system inside your cells
  1. Life Sciences

Scientists reveal a hidden alarm system inside your cells

Ludwig Maximilian University of Munich (LMU) researchers have uncovered how ribosomes are able to alert the cell when something is wrong. Ribosomes are best known as the cell’s protein builders. They attach to mRNA and travel along it, interpreting the genetic code and linking amino acids to form new proteins. Their role, however, extends beyond […]
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Flamingos reveal their secret to staying young
  1. Life Sciences

Flamingos reveal their secret to staying young

Is aging inevitable? While most living beings age, some do so more slowly than others. A new scientific study published in the Proceedings of the National Academy of Science (PNAS) addresses a fascinating question: what if migration influences the way we age? To explore this mystery, scientists turned their attention to the pink flamingo (Phoenicopterus […]
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  1. Biology

At-risk butterflies more likely to survive with human help

VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a recent study found. VANCOUVER, Wash. –  Some of the butterflies most in danger of fluttering out of existence fare better when their habitats are actively managed by humans, a […]
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  1. Biology

The unexpected structure and dynamics of vimentin networks

Bhattacharyya and Klumpp discuss exciting new observations of the native intermediate filament network in cells shown in Renganathan et al. (https://doi.org/10.1083/jcb.202406054) in this issue. Combining two powerful imaging techniques, Renganathan et al. examine the organization and dynamics of vimentin filaments in unprecedented detail. Admin Member since October 11, 2023 Loading + Follow Following
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  1. Biology

Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube

In this issue, Kim et al. (https://doi.org/10.1083/jcb.202409078) report that the scaffold protein Arc acts through Crumbs to spatially restrict where actomyosin-based apical constriction occurs across the invaginating Drosophila salivary gland. This restriction is needed for a long, thin tube to form. Admin Member since October 11, 2023 Loading + Follow Following
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