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  1. Biology

Is the Parkinson’s-associated protein TMEM175 a proton channel: Yay or nay?

The abnormal protein degradation implicated in the pathogenesis of Parkinson’s disease was previously attributed to defective H+ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K+ channel, minimally permeable to H+. Admin Member since October 11, 2023 Loading + Follow Following
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  1. Biology

What role did fear play in Europe’s population growth?

[Vienna, August 26 2024] – Since the end of the last Ice Age, growth of human population was far from uniform, marked instead by periods of rapid expansion followed by sharp declines. The reasons behind these fluctuations remain only partially understood. Previous research by CSH scientists Peter Turchin, Daniel Kondor, and an international team of collaborators, demonstrated […]
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  1. Biology

A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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  1. Biology

ALDH9A1 deficiency as a source of endogenous DNA damage that requires repair by the Fanconi anemia pathway

The Fanconi anemia (FA) DNA repair pathway is required for the repair of DNA interstrand cross-links (ICLs). ICLs are caused by genotoxins, such as chemotherapeutic agents or reactive aldehydes. Inappropriately repaired ICLs contribute to hematopoietic stem cell (HSC) failure and tumorigenesis. While endogenous acetaldehyde and formaldehyde are known to induce HSC failure and leukemia in […]
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Scientists find immune molecule that supercharges plant growth
  1. Life Sciences

Scientists find immune molecule that supercharges plant growth

Within the animal kingdom, a naturally produced molecule known as itaconate serves a prominent role in the immune system as a defensive agent against viruses and inflammation. Itaconate is classified as a metabolite, a natural compound that arises when organisms convert food into energy. While itaconate is well known in animals, its presence and functions […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Built-in dataset allows genes-to-ecosystems analysis

A primary-ever dataset bridging molecular details about the poplar tree microbiome to ecosystem-level processes has been launched by a workforce of Division of Vitality scientists led by Oak Ridge Nationwide Laboratory. The mission goals to tell analysis concerning how pure methods perform, their vulnerability to a altering local weather, and finally how crops may be […]
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A tiny mineral may hold the secret to feeding billions sustainably
  1. Life Sciences

A tiny mineral may hold the secret to feeding billions sustainably

Rice, a staple for billions, is one of the most resource-hungry crops on the planet—but scientists may have found a way to change that. By applying nanoscale selenium directly to rice plants, researchers dramatically improved nitrogen efficiency, boosted yields, and made grains more nutritious while reducing fertilizer use and cutting greenhouse gas emissions. Admin Member […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Team creates synthetic enzymes to unravel molecular mysteries

A University of Texas at Dallas bioengineer has developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in the development of muscle, bone and blood in vertebrate embryos. The team of researchers is using a new approach, called the Synthetic Processing (SynPro) system, in zebrafish to […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Study on architecture of heart offers new understanding of human evolution

An international research team from Swansea University and UBC Okanagan (UBCO) has uncovered a new insight into human evolution by comparing humans’ hearts with those of other great apes. Despite humans and non-human great apes having a common ancestor, the former has evolved larger brains and the ability to walk or run upright on two […]
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Teen bats are spawning new viruses—here’s why scientists are paying close attention
  1. Life Sciences

Teen bats are spawning new viruses—here’s why scientists are paying close attention

New research by the University of Sydney offers important insights into how and when new coronavirus variants arise in bats. Bats are beneficial to our ecosystems and economy but, as habitat destruction and environmental stressors put them in closer proximity to humans, disease risks can emerge. The research, published in Nature Communications on July 17, […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

The rhythm led by plants is crucial for symbiosis with nutrient-providing bacteria

Legumes thrive in low-nitrogen environments by partnering with rhizobia, soil bacteria that convert atmospheric nitrogen into ammonium, a usable form for the plants. These beneficial bacteria are housed in root nodules formed on legume roots. However, the uncontrolled formation of numerous root nodules can impede root function. To prevent this, legumes need to regulate the […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

How gophers brought Mount St. Helens back to life in one day

When Mount St. Helens erupted in 1980, lava incinerated anything living for miles around. As an experiment, scientists dropped gophers onto parts of the scorched mountain for only 24 hours. The benefits from that single day were undeniable — and still visible 40 years later. Once the blistering blast of ash and debris cooled, scientists […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Alcohol consumption among non-human animals may not be as rare as previously thought, say ecologists

Anecdotes abound of wildlife behaving “drunk” after eating fermented fruits, but despite this, nonhuman consumption of ethanol has been assumed to be rare and accidental. Ecologists challenge this assumption in a review publishing October 30 in the Cell Press journal Trends in Ecology & Evolution. They argue that since ethanol is naturally present in nearly […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Genetic signatures of domestication identified in pigs, chickens

Wild boars and red junglefowl gave rise to common pigs and chickens. These animals’ genes evolved to express themselves differently, leading to signatures of domestication — such as weaker bones and better viral resistance — in pigs and chickens, according to a research team based in Japan. The findings, published on July 6 in Animals, […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Engineers measure pH in cell condensates

Scientists making an attempt to grasp the bodily and chemical properties that govern biomolecular condensates now have a vital strategy to measure pH and different emergent properties of those enigmatic, albeit vital mobile compartments. Condensates are communities of proteins and nucleic acids. They lack a membrane and are available collectively and collapse as wanted. The […]
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  1. Clinical

FDA Clears Investigational New Drug application for muscular dystrophy treatment

MINNEAPOLIS and ST. PAUL, Minn., July 17, 2024. Today, Myogenica, a University of Minnesota startup company, announced U.S. Food and Drug Administration approval for an Investigational New Drug (IND) application for MyoPAXon — an induced pluripotent stem cell-derived muscle stem cell product to regenerate skeletal muscle. A pending clinical trial would evaluate the safety, tolerability […]
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