1. Pharmaceuticals and Drug Development

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  1. Biology

A new, updated account of poroid fungi in North America

Poroid fungi, commonly known as “polypores,” are among the most frequently encountered fungi throughout the year because of their large size and longevity. Despite the common presence of poroid fungi in North America, most guides include only a limited selection of these fungi. Poroid Fungi of North America, by Leif Ryvarden, offers a necessary, updated account […]
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  1. Biology

Non-cell autonomous regulation of cell–cell signaling and differentiation by mitochondrial ROS

Mitochondrial reactive oxygen species (ROS) function intrinsically within cells to induce cell damage, regulate transcription, and cause genome instability. However, we know little about how mitochondrial ROS production non-cell autonomously impacts cell–cell signaling. Here, we show that mitochondrial dysfunction inhibits the plasma membrane localization of cell surface receptors that drive cell–cell communication during oogenesis. Within […]
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  1. Biology

An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis

Precisely controlled remodeling of the basement membrane (BM) is crucial for morphogenesis, but its molecular and tissue-level dynamics, underlying mechanisms, and functional significance in mammals remain largely unknown due to limited visualization tools. We developed mouse lines in which the endogenous collagen IV gene (Col4a2) was fused with a fluorescent tag. Through live imaging of […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

Amgen Presents New Data From Phase 2 Trial of Dazodalibep in Sjögren’s Syndrome

THOUSAND OAKS, Calif., Nov. 7, 2023. Amgen (NASDAQ:AMGN) today announced new data from its Phase 2 study evaluating dazodalibep, an investigational medicine, for the treatment of Sjögren’s. These results will be featured in presentations at the American College of Rheumatology (ACR) Convergence 2023, Nov. 10-15, in San Diego. Findings from the study demonstrate that dazodalibep […]
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  1. Clinical

Constructive topline outcomes of Section 2 head and neck most cancers trial with lead NOX inhibitor candidate, setanaxib

STOCKHOLM, Could 6, 2024. Calliditas Therapeutics AB (“Calliditas”) at present introduced knowledge from the proof-of-concept Section 2 trial evaluating setanaxib, its lead NOX enzyme inhibitor, together with pembrolizumab, in sufferers with squamous cell carcinoma of the top and neck (SCCHN). The evaluation confirmed statistically important enhancements in progression-free survival (PFS), in addition to in total […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

First Patient Treated in Multi-Center Pivotal Study of Eye90 microspheres in Hepatocellular Carcinoma

HALIFAX, NS, Oct. 25, 2023. ABK Biomedical, Inc., an innovative, medical device company dedicated to the research, development, and commercialization of advanced imageable embolic medical devices, today announced the first patient treated in its Route90 US IDE Pivotal study. The Eye90 microspheres radioembolization procedure was performed by Eric A. Wang, MD, FSIR, with Charlotte Radiology […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Key protein for the biosynthesis of defense steroids in solanaceous plants discovered

Researchers at the Max Planck Institute for Chemical Ecology have identified GAME15 as a key protein that regulates the biosynthesis of both steroidal glycoalkaloids and steroidal saponins in plants of the genus Solanum. The new study published in Science shows that the protein is essential for the formation of these natural products from a cholesterol […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

How do coexisting animals find enough to eat? Biologists unlock insights into foraging habits in Yellowstone

Ecologists have long sought clarity on the dietary habits of different animal species. For scientists at Brown University and the National Park Service, it wasn’t obvious how herbivores in Yellowstone National Park, who subsist on grasses, wildflowers and trees, could compete for enough of those foods to survive the winter. Over two years, with the […]
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Positive Link Identified Between SARS-CoV-2 and Guillain-Barré
  1. Life Sciences

Positive Link Identified Between SARS-CoV-2 and Guillain-Barré

By Elana Gotkine HealthDay Reporter WEDNESDAY, Oct. 18, 2023 — There is a positive association for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Guillain-Barré syndrome (GBS), and a negative association for COVID-19 vaccination and GBS, according to a study published online Oct. 18 in Neurology. Haya Bishara, from the Lady Davis Carmel Medical […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Caterpillars can detect their predators by the static electricity they emit

Caterpillars respond defensively to electric fields similar to those emitted by their natural predators, scientists at the University of Bristol have found. In the study, published today in the journal PNAS, experts showed that caterpillar hairs move in response to electric fields and are most sensitive to the frequencies that correspond to the wingbeats frequencies […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Low stream diatom biodiversity potentially decreasing stream oxygen production in remote islands

Benthic diatoms are the most important and biodiverse primary producers in streams and comprise the basis for the food webs, fueling animals such as insects and stream fishes including trout. “It is known that highly biodiverse diatom communities are very efficient in producing oxygen” says Professor Janne Soininen from University of Helsinki. “Islands have long […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Advancements in genomic research reveal alternative transcription initiation sites in thousands of soybean genes

Rosalind Franklin, James Watson and Francis Crick discovered the structure of DNA — that molecular blueprint for life — over 70 years ago. Today, scientists are still uncovering new ways to read it. In 2010, Jianxin Ma, a professor of agronomy, and his collaborators built the first reference genome for soybeans on the widely studied […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Threat of abrupt mortality events keeps endangered monkey population at risk, despite decades of growth

Despite the population being almost four times larger than it was in 1982, a new study published in the journal Ecology suggests the northern muriqui monkeys remain at risk, especially in the face of ongoing habitat disturbances. Northern muriquis, which live in the Atlantic Forest of Brazil, are much more peaceful and egalitarian compared to […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

New model can help understand coexistence in nature

Different species of seabirds can coexist on small, isolated islands despite eating the same kind of fish. A researcher at Uppsala University has been involved in developing a mathematical model that can be used to better understand how this ecosystem works. “Our model shows that coexistence occurs naturally when species differ in their ability to […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Investigating the origin of circatidal rhythms in freshwater snails

Organisms, including humans, follow a schedule that coordinates important bodily functions such as sleep-wake cycles, metabolism, hormone production, cognitive function, and feeding habits to environmental cycles. While most organisms possess circadian rhythms synchronized with the 24-hour day-night cycle, they have also developed other internal clocks to suit their local environments. Marine animals have evolved circatidal […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Researchers uncover how we understand bitter style

People can sense 5 completely different tastes: bitter, candy, umami, bitter, and salty, utilizing specialised sensors on our tongues known as style receptors. Apart from permitting us to take pleasure in scrumptious meals, the feeling of style permits us to find out the chemical make-up of meals and prevents us from consuming poisonous substances. Researchers […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Strength training activates cellular waste disposal

The elimination of damaged cell components is essential for the maintenance of the body’s tissues and organs. An international research team led by the University of Bonn has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such mechanisms. The findings could form the basis for new therapies […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Pharmaceuticals and Drug Development

Sun Pharma Announces US FDA Filing Acceptance of New Drug Application for Deuruxolitinib

Treatment for: Alopecia Areata Sun Pharma Announces US FDA Filing Acceptance of New Drug Application for Deuruxolitinib Mumbai, INDIA and Princeton, N.J., October 06, 2023 – Sun Pharmaceutical Industries Ltd (Reuters: SUN.BO, Bloomberg: SUNP IN, NSE: SUNPHARMA, BSE: 524715, “Sun Pharma” and includes its subsidiaries or associate companies) today announced that the U.S. Food and […]
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  1. Nonclinical

Beyond patient care: Unlocking the potential of nonclinical careers for physicians

Title: Beyond Patient Care: Unlocking the Potential of Nonclinical Careers for Physicians Introduction: The medical field offers a diverse range of career paths beyond traditional patient care, providing physicians with ample opportunities to utilize their expertise and make a lasting impact in various nonclinical roles. Exploring these alternative career paths not only contributes to the […]
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