Is the Parkinson’s-associated protein TMEM175 a proton channel: Yay or nay?

The abnormal protein degradation implicated in the pathogenesis of Parkinson’s disease was previously attributed to defective H⁺ leakage from lysosomes via TMEM175 (https://doi.org/10.1016/j.cell.2022.05.021). In this issue, Riederer et al. (https://doi.org/10.1083/jcb.202501145) demonstrate that TMEM175 is instead a K⁺ channel, minimally permeable to H⁺.

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