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Newborn daughters get a fresh start through PI(3,5)P 2 -mediated vacuolar acidification

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Huda et al. (https://doi.org/10.1083/jcb.202406170) reveal a transient, cell cycle–dependent increase in PI(3,5)P2 levels at the lysosome-like vacuole of yeast daughter cells. The resulting lipid asymmetry alters vacuolar pH in both daughter and mother cells and will impact multiple downstream functions.

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