All-Trigger Mortality Threat Up for Males With Low Testosterone

Medically reviewed by Medicine.com.

By Elana Gotkine HealthDay Reporter

MONDAY, Could 13, 2024 — The danger for all-cause mortality is elevated for males with low testosterone, excessive luteinizing hormone, or very low estradiol, based on a assessment printed on-line Could 14 within the Annals of Inner Drugs.

Bu B. Yeap, M.B.B.S., Ph.D., from the College of Western Australia in Perth, and colleagues carried out a scientific assessment to make clear associations of intercourse hormones with mortality and heart problems (CVD). 9 research supplied particular person participant information (IPD; 255,830 participant-years), and abstract estimates have been supplied by 11 research (24,109 contributors).

The researchers discovered that two-stage random-effects IPD meta-analyses indicated increased all-cause mortality for males with baseline testosterone concentrations beneath 7.4 nmol/L, luteinizing hormone concentrations above 10 IU/L, or estradiol concentrations beneath 5.1 pmol/L; increased CVD mortality threat was seen for these with testosterone concentrations beneath 5.3 nmol/L. Decrease intercourse hormone-binding globulin focus was related to decrease all-cause and CVD mortality (adjusted hazard ratios, 0.85 and 0.81, respectively, for quintile 1 versus 5). Larger threat for all-cause and CVD mortality was seen for males with decrease baseline dihydrotestosterone concentrations (adjusted hazard ratios, 1.19 and 1.29, respectively, for quintile 1 versus 5); threat elevated with concentrations above 2.45 nmol/L. An elevated threat for incident CVD occasions was seen for males with dihydrotestosterone concentrations beneath 0.59 nmol/L.

“We discovered that the testosterone focus beneath which males had increased threat for all-cause mortality was 7.4 nmol/L (213 ng/dL),” the authors write. “This provides to data on reference ranges based mostly on distributions of testosterone in chosen samples of wholesome males.”

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