1. Biotechnology

Singapore drug discovery platform heads to Nasdaq via SPAC deal

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An AI-driven drug discovery platform will receive a step up onto the Nasdaq via a reverse merger with a blank check company.

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Tokyo, Japan – Researchers from Tokyo Metropolitan University have discovered that the fern Hymenasplenium murakami-hatanakae can become independent gametophytes i.e. live for long periods without a spore-producing sporophyte. They collected specimens from Izu-Oshima Island, Japan, and used DNA analysis to show that this Aspleniineae fern, a suborder encompassing thirty percent of ferns on the planet, […]
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ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates

Protein aggregates are degraded by both the autophagy–lysosomal and the ubiquitin–proteasome pathways. Macroautophagy and microautophagy, two forms of the autophagy–lysosomal pathway, are widely conserved across eukaryotes. While macroautophagy has been extensively studied in the context of degradation of protein aggregates, microautophagy remains less explored. Here, we identify the UBAP1-containing ESCRT-I complex and PTPN23 as new […]
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How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported […]
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  1. Biology

Enhanced information in national policies can accelerate Africa’s

New analysis of African national adaptation policy documents finds that most fail to provide comprehensive and consistent information. But the authors also uncover compelling examples of robust plans which hold lessons for upcoming climate talks.   New analysis of African national adaptation policy documents finds that most fail to provide comprehensive and consistent information. But […]
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Tubulin isotypes contribute opposing properties to balance anaphase spindle morphogenesis

Faithful chromosome segregation requires proper function of the mitotic spindle, which is built from, and depends on, the coordinated regulation of many microtubules and the activities of molecular motors and MAPs. In addition, microtubules themselves are assembled from multiple variants, or isotypes of α- and β-tubulin, yet whether they mediate the activities of motors and […]
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A coordinated kinase and phosphatase network regulates Stu2 recruitment to yeast kinetochores

Cells coordinate diverse events at anaphase onset, including separase activation, cohesin cleavage, chromosome separation, and spindle reorganization. Regulation of the XMAP215 family member and microtubule polymerase, Stu2, at the metaphase-anaphase transition determines a redistribution from kinetochores to spindle microtubules. We show that cells modulate Stu2 kinetochore-microtubule localization by Polo-like kinase1/Cdc5-mediated phosphorylation of T866, near the […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Mystery of ‘very odd’ elasmosaur finally solved: fiercely predatory marine reptile is new species

A group of fossils of elasmosaurs — some of the most famous in North America — have just been formally identified as belonging to a “very odd” new genus of the sea monster, unlike any previously known. Long-necked and measuring in at 12 metres, Traskasaura sandrae — as it is officially named today in this […]
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  1. Life Sciences

Two new crocodile species discovered

McGill University researchers, in collaboration with Mexican scientists, have discovered two previously unknown species of crocodiles, one living on the island of Cozumel and the other on the atoll of Banco Chinchorro, both off the Yucatán Peninsula. The findings challenge long-held assumptions about the American crocodile (Crocodylus acutus) and highlight the urgent need for conservation […]
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  1. Life Sciences

How elephants plan their journeys: New study reveals energy-saving strategies

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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Scientists find a region of the mouse gut tightly regulated by the immune system

The intestine maintains a delicate balance in the body, absorbing nutrients and water while maintaining a healthy relationship with the gut microbiome, but this equilibrium is disrupted in parts of the intestine in conditions such as celiac disease, ulcerative colitis, and Crohn’s disease. Scientists don’t fully understand how different regions of the organ resist or […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

New dart launcher may be better way to inject animals with drugs

A new type of dart launcher has been developed as a safer and more cost-effective alternative to firearms or air guns to inject animals with drugs or tracking chips. Utilizing electromagnetic coils and lidar technology, the prototype was able to consistently deliver a projectile to a target with enough controlled kinetic energy to suggest that […]
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Scientists uncover new way viruses fight back against bacteria
  1. Life Sciences

Zika virus uses cells’ ‘self-care’ system to turn against host

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It’s not just genes — parents can pass down longevity another way
  1. Life Sciences

It’s not just genes — parents can pass down longevity another way

New research in the roundworm C. elegans shows how changes in the parent’s lysosomes that promote longevity are transferred to its offspring. The work describes a new link between lysosomes — cellular organelles once thought to be the cell’s recycling center — and the epigenome — a set of chemical marks that modify gene expression. […]
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Scientists uncover a mysterious Jurassic lizard with snake-like jaws
  1. Life Sciences

Scientists uncover a mysterious Jurassic lizard with snake-like jaws

New research has uncovered a species of hook-toothed lizard that lived about 167 million years ago and has a confusing set of features seen in snakes and geckos — two very distant relatives. One of the oldest relatively complete fossil lizards yet discovered, the Jurassic specimen is described in a study, published on October 1 in […]
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Florida cat sniffs out another new virus—and scientists are listening
  1. Life Sciences

Florida cat sniffs out another new virus—and scientists are listening

Pepper, the pet cat who made headlines last year for his role in the discovery of the first jeilongvirus found in the U.S., is at it again. This time, his hunting prowess contributed to the identification of a new strain of orthoreovirus. John Lednicky, Ph.D., Pepper’s owner and a University of Florida College of Public […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

NIH Researchers Develop Approach That Could Help Supercharge T-Cell Therapies Against Solid Tumors

November 1, 2023 — Researchers at the National Institutes of Health have developed a way to potentially increase the effectiveness of T cell–based immunotherapy treatments, such as CAR T-cell therapy, against solid tumors. T cells are specialized white blood cells of the immune system that eliminate infected or abnormal cells. In animal studies, the enhanced […]
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Takeda Announces Topline Results of Phase 3 ADMIRE-CD II Trial of Alofisel® (darvadstrocel) in Complex Crohn’s Perianal Fistulas
  1. Clinical

US Study Reveals CP-GEP’s Profound Impact on Stratifying Melanoma Patients for Long-Term Survival

ROTTERDAM, Netherlands and SAN DIEGO, Nov. 6, 2023 . SkylineDx, an innovative molecular diagnostics company, is pleased to announce the forthcoming presentation of an impactful poster by Dr M.E. Egger at the upcoming Society for Melanoma Research Congress in Philadelphia. Dr. M.E. Egger’s presentation promises to usher in a new paradigm in disease staging and […]
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